Caffeic acid ntụ ntụ

Ntụ ntụ Caffeic Acid YTBIO dị elu | Ihe mejupụtara ya dị irè nke ukwuu | Ihe eji egbochi oxidant na mgbochi nje bacteria

Asịd caffeic nke YTBIO bụ asịd organic dị ọcha nke ukwuu (99%) (C9H8O4). Ọdịdị ortho- na tho-dihydroxyl ya bụ isi ihe na-eme ka ọrụ antioxidant, antibacterial, na antiviral dị elu. Dịka metabolite nke abụọ sitere na ụzọ shikimic acid, a naghị ahụ ya nke ọma na nri dị iche iche na ọgwụ ọdịnala ndị China, kamakwa a na-anụcha ya ka ọ bụrụ ntụ kristal odo odo site na iji teknụzụ mwepụta sayensị. Ọ nwere ezigbo mgbaze na mmiri ọkụ na ethanol, yana nchekwa nke ọkwa ịchọ mma. E gosipụtala nke ọma na ọtụtụ ihe ndị dị ndụ nke caffeic acid na ihe ndị sitere na ya (dị ka rosmarinic acid, salvianolic acid, na chlorogenic acid), na-ekpuchi ebe ahụike kachasị ọhụrụ site na mgbochi mbufụt na scavenging free radical ruo na nchedo obi na mmezi metabolic nwere ike. YTBIO na-enye ihe a dị ike site na njikwa usoro ziri ezi, dabara adaba maka mmepe nhazi na ngwa ngwaahịa ahụike na-achọ nsonaazụ dị mma na nke dị irè.

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Ọrụ mgbochi

N'ime afọ ndị na-adịbeghị anya, nchọpụta achọpụtala na caffeic acid na ihe ndị na-emepụta ya nwere ezigbo nje na-egbochi influenza na mgbochi nje HIV. Caffeic acid nwere ike igbochi mgbasa nke nje influenza A ma gbochie mgbasa nke nje ịba ọcha n'anya C na mmalite nke ọrịa ịba ọcha n'anya C. Caffeic acid phenethyl ester, nke sitere na caffeic acid, bụ ihe sitere n'okike achọpụtara n'afọ ndị na-adịbeghị anya nwere ihe mgbochi nje HIV doro anya. Na mgbakwunye, lithospermic acid na salvianolic acid B nwere ọrụ siri ike na igbochi ụdị nje virus immunodeficiency mmadụ I (HIV-I) integrase, yana IC5 nke 0.83 na 0.48 mol/L n'otu n'otu, na-atụ anya na ọ ga-aghọ ọgwụ ọhụrụ eke maka ọgwụgwọ ọrịa AIDS. . Na mgbakwunye na nje nje HIV, a na-ejikọta caffeic acid na quinic acid site na mmeghachi omume esterification iji mepụta usoro nke ogige phenolic acid, nke a na-akpọ caffeoylquinic acid, nke ihe mejupụtara chlorogenic acid nọchiri anya ya. Ụdị onyinye a dị n'ọtụtụ ebe n'ime osisi ndị dị ka Asteraceae, Fabaceae, Apiaceae, Convolvulaceae, wdg, nchọpụta achọpụtala na ụdị ihe a nwere ezigbo ọrụ mgbochi ma nwee ike igbochi nje influenza na nje ịba ọcha n'anya B. Nnyocha e mere n'oge na-adịbeghị anya achọpụtala na chlorogenic acid na caffeic acid dị na forsythin nwere ike igbochi mgbasa nke nje gastroenteritis porcine transmissible (TGEV) na mkpụrụ ndụ testicular porcine (ST). N'ime ha, caffeic acid nwere ike ibelata ọrụ nje. A na-atụ anya na a ga-emepụta ya ka ọ bụrụ ọgwụ mgbochi nje.

Antibacterial, mgbochi ọrịa

Caffeic acid na ihe ndị sitere na ya bụ ihe fungicides eke nwere ike igbochi ụdị fungal na nje nje. Nnyocha egosiwo na usoro nje bacteria nke ihe mejupụtara caffeic acid na-ejikọta ya na njirimara antioxidant siri ike ya. Salvianolic acid A na Salvia miltiorrhizae nwere ezigbo mgbochi mkpali ọrụ mgbe ultrasonic mmịpụta. Acid chlorogenic dị na Panax notoginseng, honeysuckle na Eucommia ulmoides nwere ọrụ antibacterial siri ike ma nwee ike ịmepụta ya dị ka ihe nchekwa nri eke. Nnyocha ndị ọzọ egosila na mmetụta mgbochi nke chlorogenic acid components na E. coli bụ n'ihi eziokwu ahụ bụ na ihe ndị a nwere ike ibibi mgbidi cell cell na akpụkpọ ahụ, na-eduga n'ịba ụba nke cell permeability, nke na-akpata nkwụsị nke cell. ọdịnaya na-eduga na cell apoptosis. .

Ọrịa cardiovascular

A na-eji nkwadebe Salvia miltiorrhiza eme ihe na ọgwụgwọ ụlọ ọgwụ nke ọrịa obi na akwara ozi. Ihe ndị bụ isi kemịkalụ na-egosipụta mmetụta ọgwụ ọgwụ bụ salvianolic acid na ihe ndị ọzọ na-emepụta caffeic acid. Nnyocha achọpụtala na ihe ndị dị na salvianolic acid nwere mmetụta mgbochi siri ike megide mmerụ ahụ ischemia-reperfusion nke ụbụrụ, nwere ike igbochi nchịkọta platelet, ma nwee mmetụta mgbochi thrombotic dị mma. Mkpokọta salvianolic acid nwere ike igbochi thrombosis ma belata ọkwa endothelin plasma na thromboxane B2 mgbe ischemia cerebral gasịrị.

Fibrosis mgbochi imeju na mmetụta hepatoprotective

Fibrosis imeju na-ezo aka n'ụzọ na-adịghị mma nke anụ ahụ jikọtara na imeju nke ihe dị iche iche na-akpata ọrịa kpatara. Ọ bụ n'ihi mmebi nke imeju parenchyma anụ ahụ na biliary usoro. Nnyocha achọpụtala na ma salvianolic acid A na B na-egosipụta ọrụ hepatoprotective siri ike, na lithospermic acid nwere ike iguzogide mmebi imeju nke nrụgide oxidative kpatara. Danshensu nwere ike igbochi fibrosis imeju site na ụzọ akara MEK/ERK, yana caffeic acid phenethyl ester nwere ike iguzogide nrụgide oxidative ma gbochie ọrụ nke mkpụrụ ndụ hematopoietic stem cell (HSC), ya mere o nwere njirimara mgbochi imeju fibrosis.

ọgwụgwọ mmetụta na-arịa ọrịa shuga

N'afọ ndị na-adịbeghị anya, ọmụmụ egosila na enwere njikọ dị n'etiti ọrịa shuga na nrụgide oxidative, na mmetụta antioxidant nke caffeic acid na ihe ndị sitere na ya na-ekerekwa òkè dị mma na ọgwụgwọ ọrịa shuga. Caffeic acid nwere ike ibelata nnabata nke glucose site na mkpụrụ ndụ endothelial, na-akwalite mwepu nke glycogen n'ime imeju, ma na-achịkwa mmetụta nke pancreatin site na ịbawanye nnabata glucose nke adipocytes, si otú a na-ebelata ọkwa shuga dị n'ọbara. Ihe ndị na-emepụta caffeic acid caffeic acid methyl ester (CAME), caffeic acid ethyl ester (CAEE), na caffeic acid phenethyl ester (CAPE) nwere ike ibelata nnabata glucose site na mkpụrụ ndụ C2C12. Sinapic acid nwere ike ibelata ọkwa glucose dị elu na-ebute oke vaskụla vaskụla mkpụrụ ndụ dị nro ma kwalite apoptosis cell site na igbochi ọrụ PKC/P38, enwere ike iji ya mee ihe maka mgbochi na ọgwụgwọ nke nsogbu ọrịa shuga. Salvianolic acid A nwere ike ịgwọ ọrịa shuga site na ịgbalite AMPK iji mezie mitochondria.

Ntuziaka ngwa

Site na ọganihu nke nyocha sayensị, usoro ụzọ biosynthetic nke caffeic acid na ihe ndị sitere na ya na-aghọwanye nke zuru oke. Mmekọrịta nhazi-mmekọrịta nke caffeic acid na usoro ya ka aghọtakwara na mbụ. Dịka ọmụmaatụ, ọrụ ndụ ya nwere njikọ chiri anya na otu hydroxyl na mgbanaka benzene ya. Mgbe hydrogen dị na mgbanaka benzene jiri ụfọdụ ndị na-adọta eletrọn dochie ya, ọrụ ndụ ya na-esiwanye ike. Enwere ike nweta nke a site na kemịkalụ Usoro sịntetịt na-agbanwe ihe ndị nọchiri anya na mgbanaka benzene ka ọ bụrụ ebumnuche na imepụta ihe ọhụrụ caffeic acid iji kwalite ọrụ ndu ha.

Achịcha Caffeic Acid na ihe ndị sitere na ya nwere ọrụ dị ndụ dịka ọgwụ nje, nje bacteria, ọgwụ nje, na ọgwụgwọ ọrịa obi na akwara. E jirila ha mee ihe n'ọgwụ. Ụfọdụ ọgwụ maka ọgwụgwọ ọrịa obi na akwara nwere caffeic acid na ihe ndị sitere na ya. , dị ka mbadamba caffeic acid enwere ike iji gwọọ leukopenia, a pụkwara iji sodium ferulate gwọọ atherosclerosis. Na mgbakwunye na ojiji ha n'ọhịa ahụike, caffeic acid na ihe ndị sitere na ya aghọwokwa ebe nchọpụta ọhụrụ n'ọhịa ndị ọzọ.

Dịka ọmụmaatụ, caffeic acid na ihe ndị sitere na ya nwere ọrụ antioxidant na sistem emulsification nri ma nwee ike ịgbatị ndụ nri. Caffeic acid na ester ester na-arụ ọrụ antioxidant na usoro emulsification nke Mayonezi, mmiri ara ehi na mmanụ azụ kpụrụ. Ọrụ antioxidant nke caffeic acid na ihe ndị sitere na ya na-eme ka ọ bụrụ ihe mgbakwunye na nchekwa na nchekwa nri. Dị ka ngwaahịa eke dị mma ma dị irè, caffeic acid na ihe ndị sitere na ya nwere ọrụ dị iche iche nke ndu. A kwenyere na site na nyocha miri emi, a ga-ejikwa ha dị ka ihe mgbakwunye nri na nri nri n'ọdịnihu.

Caffeic acid soplaya

Ngwugwu & Mbupu

Ụlọ ọrụ anyị na ụlọ ọrụ mmepụta ihe

Yuantai Organic Bio na-agba mbọ inye ndị ahịa ntụ ntụ na ọrụ kachasị mma nke caffeic acid ka onye ọ bụla wee nwee ike iri nri sitere n'okike, nke dị mma, na nke dị elu. Ọ bụrụ na ị nwere ajụjụ ma ọ bụ mkpa ọ bụla gbasara ngwaahịa anyị, biko kpọtụrụ anyị, anyị ga-aza gị ozugbo enwere ike.