Chain Amino Acids ntụ ntụ

Kedu ihe bụ amino acids nwere agba agba?

Amino acid nke nwere ngalaba (BCAAs) bụ ihe mgbakwunye nri nke na-ewu ewu kemgbe ihe dị ka 1980. Ọ bụ aha mkpokọta maka amino acid atọ, gụnyere valine, leucine na isoleucine, n'ihi na e nwere otu methyl n'ime usoro ihe omimi. A na-akpọ yinye akụkụ nke ntọala amino acid nwere alaka. N'ime afọ ndị na-adịbeghị anya, a na-eji amino acids nwere eriri agba agba n'ọtụtụ ebe na ụlọ ọrụ ahụike ma ọ bụ ahụike n'ihi mmetụta ha pụrụ iche.

1. Leucine

Otu n'ime isi ọrụ nke leucine n'ime ahụ bụ inye aka kwalite uto uru ahụ n'ọkwa molekụla. Mgbe a na-eri leucine zuru oke (ihe dị ka gram 3), a na-amalite akara mkpụrụ ndụ n'ime anụ ahụ, na-eduga na njikọ protein muscle. Nke abuo, leucine nwekwara ike ime ka pancreas weputa insulin. Nke a na-enyere aka ibelata ndakpọ protein akwara ma na-enyere aka ịbawanye ụlọ ahịa glycogen. Ịkwalite njikọ protein muscle na ịkpalite nzaghachi insulin, nri zuru oke nke leucine mgbe mgbatị ahụ gasịrị na-enyere aka mgbake.

2.Isoleucine

Otu mmetụta a ma ama nke isoleucine bụ ịbawanye ọnụọgụ glucose nke mkpụrụ ndụ akwara na-etinye n'ime ya. Isoleucine, jikọtara ya na leucine, nwere ike ịdị irè karịa iwere naanị ya.

3.Valine

A na-elekarị Valine anya dị ka BCAA nnukwu ntụ ntụ nke mgbakwunye ọdịdị. Nke a bụ n'ihi na ọrụ valine kacha mara amara bụ ịtụgharị onwe ya na glucose. E gosiputara na ọ na-etinye aka na ụfọdụ nrụzi anụ ahụ, mana o yighị ka ọ dị irè dị ka leucine na isoleucine.

Isi mmalite na ebe a na-enye BCAA na ojiji ya. 

Amino acids nke nwere alaka (BCAA) - isoleucine, leucine na valine - bụ amino acid dị mkpa. A na-enweta BCAA site na nri na protein hydrolysis, yana ntinye dị nta site na njikọ de novo site na microbiota intestinal. A na-eji BCAA na-ekesa kesa na njikọ protein ma ọ bụ metabolism. A na-ebubata amino asịd nwere yinye alaka na mitochondria site na mitochondrial branched-chain amino acid bu SLC25a44. Nzọụkwụ abụọ mbụ nke agbụ amino acid catabolic nke nwere alaka na-agbaziri site n'aka aminotransferase (BCAT) na branched-chain alpha-ketoacid dehydrogenase (BCKDH), nke amino asịd atọ nwere alaka. Ụzọ catabolic akwụsị na triarboxylic acid (TCA) okirikiri, ma na-emepụta mkpa metabolic intermediates, dị ka valine metabolite 3-hydroxyisobutyric acid (3-HIB) na monomethyl branched-chain fatty acids (mmBCFAs), Ha na-enye aka na intracellular na akara paracrine.

Kedu uru nke amino acid yinye alaka?

01 Nye ume maka mmega ahụ

Dị ka amino acid ndị ọzọ, ọrụ anyị bụ isi bụ ihe eji arụ ọrụ maka njikọ protein. N'ihi na ọ na-agbajikarị na akwara, ọ nwere ike inye ume maka mgbatị ahụ.

02 Mee ka ikike njikọ anụ ahụ dịkwuo elu ma gbochie mfu ahụ

Otu bụ ịkwalite ntọhapụ nke insulin, na-ekwe ka mọzụlụ na-amịkọrọ shuga dị n'ọbara iji mejupụta ume, ma n'otu oge ahụ na-akwalite nnabata nke amino acid site na mọzụlụ. Nke abụọ bụ ịkwalite ntọhapụ nke hormone na-eto eto, na-enyere ahụ aka ịnọgide na-enwe ezi testosterone/cortisol ratio, ma kwalite njikọ protein nke ukwuu. Ọ bụ ezie na m na-akwalite anabolism, ọ na-enwekwa mmetụta anti-catabolic dị mma, na-enyere aka igbochi nkwụsị nke protein na nkwụsị ahụ.

03 Mmetụta ike ọgwụgwụ

N'oge mmega ahụ, a na-atụgharị tryptophan ka ọ bụrụ 5-hydroxytryptamine (5-HT), ihe na-akpata ịda mbà n'obi na-akpata mgbaàmà ike ọgwụgwụ n'ime ahụ. A na-ebufe anyị na tryptophan site n'otu ụgbọelu ahụ. Mgbe "na-asọmpi" na tryptophan n'otu ọwa ahụ, ọ nwere ike igbochi ntụgharị nke tryptophan, belata mmepụta nke 5-hydroxytryptophan na ụbụrụ, ma belata 5-hydroxytryptophan. -Ọdịnaya nke HT na-egbu oge ma ọ bụ na-egbochi mwepụta nke "ozi ike ọgwụgwụ", na-eme ka ahụ dịkwuo ogologo.

04 Mepụta protein

Na-achịkwa biosynthesis protein n'ime ahụ. Na protein akwara, 35% nke amino acids dị mkpa bụ amino asịd nwere eriri.

05 na-arụ ọrụ dị ka ihe na-egosi ma na-ekere òkè na metabolism ike

Amino acid nke nwere agbụ nwere ike ije ozi dị ka ụmụ irighiri ihe dị mkpa, na-achịkwa uto cell na njikọ neurotransmitter. Na-etinye aka na metabolism nke glucose na fatty acids.

06 nwere ọrụ immunomodulatory

Chain Amino Acids ntụ ntụ nwere ike kwalite ozugbo na mgbake nke ọrụ cell na-alụso ọrịa ọgụ, melite usoro ahụ ji alụso ọrịa ọgụ mebiri emebi, ma melite ọnọdụ nri nke ndị ọrịa nwere ọrịa kansa na ọrịa imeju.

Amino acid nke nwere eriri alaka ọ na-enyere aka n'ịrụ egwuregwu?

Amino acids nke nwere ngalaba (BCAA) na amino acid ndị ọzọ dị mkpa na-eme ka arụmọrụ egwuregwu dịkwuo mma n'ihi na ha na-akwado ihe mgbaru ọsọ ike na ntachi obi gị.

Ihe mgbakwunye BCAA nwere ike ịbawanye ọkwa oxygen na-ekesa, nke na-enyere aka melite ntachi obi ma belata ike ọgwụgwụ n'oge mmega ahụ.

Branched-yinye amino acid na-enyekwa aka idobe ụlọ ahịa glycogen nke anụ ahụ (na metabolites ume ndị ọzọ). A na-echekwa glycogen n'ime akwara ma bụrụ isi iyi nke anụ ahụ maka mmepụta ume. N'oge mgbatị ahụ, ahụ na-eji ụlọ ahịa a maka ume.

Mgbe ụlọ ahịa glycogen agwụla, ndị mmadụ na-enweta ike ọgwụgwụ na arụ ọrụ ọzụzụ kacha mma na-egbochi. Otú ọ dị, amino acids nwere eriri nwere ike inye aka chekwaa ụlọ ahịa glycogen n'oge mgbatị ahụ, na-enye ndị mmadụ ohere ịkwado mgbatị ahụ ogologo oge ma na-ebelata mmetụta nke mmebi ahụ n'oge ọzụzụ.

Ha na-ebelata ọkwa ọbara nke creatine kinase na lactate dehydrogenase, nke abụọ bụ ihe na-emerụ ahụ ike.

Nwere ike ibelata mgbu mgbu akwara mmalite (DOMS)

Na mgbakwunye na inye aka melite arụmọrụ anụ ahụ, ihe mgbakwunye amino acid nke nwere alaka na-egosi na ọ na-ebelata ahụ mgbu. Dị ka ị maara, obere ahụ mgbu pụtara ọzụzụ oge karịa.

Mbelata nke ọzịza anụ ahụ na-atụnyekwa aka n'ikike BCAA nwere imeziwanye na ịkwalite arụmọrụ mmega ahụ.

Mgbe ị na-agbakwunye na BCAA, ọnya anụ ahụ na-ebelata ma na-edozi eriri anụ ahụ mebiri emebi ngwa ngwa, na-enye gị ohere ịme mgbatị ahụ ugboro ugboro na-enweghị mkpa izu ike n'etiti.

Oge mgbake nke BCAA na-abawanye ọ bụghị naanị na-enyere aka na uto akwara mana ọ na-enye gị ohere ịnọ na mgbatị ahụ ọtụtụ oge ka ị nwee ike ịga n'ihu na-arụ ọrụ maka ebumnuche ahụike gị.

Na-egbochi atrophy muscle

Chain Amino Acids ntụ ntụ nwekwara ike inye aka gbochie atrophy muscle, ma ọ bụ nkwụsị nke protein protein, nke n'ezie na-ewepụ site na ụlọ anụ ahụ.

Enwere ọtụtụ ọmụmụ na-egosi na imeju na amino asịd nwere yinye alaka nwere ike igbochi ndakpọ protein akwara.

Nke a dị mkpa ọ bụghị naanị maka ndị na-eme egwuregwu na-achọ imeziwanye ọganihu ahụ ike na mgbatị ahụ, kamakwa maka ụfọdụ ndị na-adịghị ike, dị ka ndị agadi, ma ọ bụ ndị nwere ọrịa cancer ma ọ bụ ọrịa imeju, bụ ndị na-enwekarị ụkọ nri na-edozi ahụ na atrophy muscle.

Ebe ọ bụ na BCAA mejupụtara ihe dịka 35% nke profaịlụ amino acid nke akwara, ọ dị mkpa ịgbakwunye BCAA iji gbochie ndakpọ akwara ma kwalite uto akwara.

Nwere ike inyere ndị nwere ọrịa imeju aka

Ọ bụ ezie na ọtụtụ n'ime mgbasa ozi gbasara BCAA dị n'ime obodo ahụike, BCAA nwere ụfọdụ ojiji ụlọ ọgwụ, dị ka inyere ndị nwere cirrhosis aka (ọrịa imeju).

Na ntọala ụlọ ọgwụ, a na-enye ndị ọrịa nwere cirrhosis ihe mgbakwunye BCAA iji nyere aka belata mmebi imeju ma melite ọrụ akụkụ ahụ.

N'ihi nhazi kemịkalụ pụrụ iche ha, amino acids nke nwere alaka nwere ike inye aka mee ka mkpụrụ ndụ imeju dị mma pụta ìhè, si otú ahụ na-enyere aka melite ọrụ imeju.

Ọ dị mkpa iburu n'obi na nyocha anaghị akwado iji amino acids nke nwere alaka na-eme ka ahụike imeju dịkwuo mma na ndị imeju ha dịlarị mma.

Asambodo

YTBIO na-agba mbọ inye ndị ahịa ihe kacha mma BCAA nnukwu ntụ ntụ dị ọcha na ọrụ ka onye ọ bụla na-azụ ahịa nwee ike ịnụ ụtọ nri eke, ahụike yana oke mma. Ọ bụrụ na ị nwere ajụjụ ọ bụla ma ọ bụ mkpa gbasara ngwaahịa anyị, biko nweere onwe gị ịkpọtụrụ anyị, anyị ga-azaghachi gị ozugbo enwere ike.

Ngwugwu & Mbupu

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