Imeghe uru nke Quercetin ntụ ntụ maka ahụike na ahụike

Kedu ihe bụ Quercetin?

Quercetin, nke a makwaara dị ka quercetin, bụ ngwakọta flavonol nke ekesara n'ọtụtụ ebe n'alaeze osisi nwere ọrụ dịgasị iche iche nke ndu, na usoro kemịkal ya bụ C15H10O7. Dị ka ihe mgbochi apoptosis na antioxidant, quercetin nwere ike ichebe mmebi akụkụ dị iche iche, yana mgbochi mkpali, antibacterial, anti-virus, ibelata shuga ọbara, ibelata ọbara mgbali, na-achịkwa ọrụ mgbochi na ichekwa obi. Quercetin dị ebe niile na ogbugbo osisi, ifuru, akwụkwọ, buds, mkpụrụ, na mkpụrụ osisi nke ọtụtụ osisi, ọkachasị n'ụdị glycosides, dị ka rutin, quercitrin, hyperin, wdg, nke nwere ike nweta site na acid hydrolysis corticosteroids. N'ime ha, ọdịnaya dị elu na mkpanaka na akwụkwọ nke buckwheat, oké osimiri buckthorn, hawthorn, na yabasị. A na-ahụkwa Quercetin n'ọtụtụ nri dị ka eyịm, shallots, asparagus, kabeeji, akwụkwọ nri mọstad, ose na-acha akwụkwọ ndụ akwụkwọ ndụ, chicory, grapefruit, letus, hawthorn, apụl, mango, plums, radishes, black currants, poteto, na akwụkwọ nri. Na mgbakwunye, enwere ihe karịrị 100 ụdị osisi ọgwụ nwere ihe a.

Ọrụ nke Quercetin

1. Antioxidant, mkpochapụ radical free

Quercetin bụ otu n'ime antioxidants kachasị ike na okike, na ikike antioxidant ya bụ ugboro 50 nke vitamin E na ugboro 20 nke vitamin C. Quercetin nwere usoro 3,7-hydroxyl, nke nwere ike inwe mmetụta dị mma na-ekpo ọkụ na anion superoxide, hydroxyl radicals na singlet oxygen, na mmekọrịta dose-mmetụta doro anya. Usoro nke quercetin's anti-oxidation na free radical scavenging nwere ike ịbụ na quercetin complexes na superoxide anion iji belata ọgbọ nke oxygen free radicals; ogige ndị nwere ion ígwè iji gbochie nguzobe nke radicals free hydroxyl; Mmeghachi omume na-egbochi usoro nke lipid peroxidation; na-egbochi aldose reductase, na-ebelata oriri NADPH, si otú a na-emeziwanye ikike antioxidant nke ahụ.

2. Mbelata lipids ọbara

Quercetin nwere ike igbochi ire ere nke esters cholesterol n'ime cholesterol efu, ma nwee ike ibelata solubility nke cholesterol na ngwọta micellar, na-egbochi nnabata nke cholesterol n'ime eriri afọ, wee mezuo ebumnuche iweda lipids.

3. Hypoglycemic

Quercetin nwere ike igbochi ibufe glucose site na onye na-ebu glucose, ma gbochie ọrụ α-amylase na α-glucosidase iji gbochie mgbaze na nnabata glucose.

4. Belata nhazi nke uric acid

Quercetin na-ejikọta na molybdenum atom nke ebe ọrụ XO (flavoproteinase) site na njikọ hydrogen, nke na-egbochi mkpụrụ xanthine ịbanye na etiti XO na-arụ ọrụ, si otú ahụ na-egbochi ọrụ catalytic XO na xanthine na ibelata mmepụta nke uric acid.

5. Mmekọrịta na usoro enzyme ndị ọzọ

Quercetin nwere ike ibelata nzuzo nke histamine nke mkpụrụ ndụ mast na basophil n'anụ ahụ dị iche iche, ma na-ekere òkè dị ukwuu site na imetụta enzymes ndị ọzọ na-adabere na calmodulin.

6. Mmetụta mgbochi neuroprotective

Quercetin nwere ike ikpochapụ ROS ozugbo, gbochie amyloid beta protein (Aβ), mgbochi hyperphosphorylation tau protein, mgbochi neurofibrillary tangles (NFTs) na mkpụrụ ndụ akwara, mgbochi amyloid precursor protein (APP), na mgbochi lyase (BACE1) na usoro ndị ọzọ. iji mepụta mmetụta mgbochi neuroprotective.

7. Antithrombotic

Quercetin nwere ike igbochi nchịkọta platelet nke ọma, họrọ ya na thrombus na mgbidi arịa ọbara wee hapụ thrombolysin na mgbasa ozi nchekwa vaskụla site na intima nke arịa ọbara site na igbochi platelet lipoxygenase na cyclooxygenase, na-arụ ọrụ Antithrombotic.

8. Antiviral

Quercetin nwere ọrụ antiviral megide ọtụtụ nje ndị dị ka ụdị I herpes simplex virus, respiratory syncytial virus, rabies virus, ụdị III parainfluenza virus na ọhụrụ Biss virus, na antiviral usoro ya nwere ike ịbụ ya nwere ike ijikọ na viral proteins na igbochi njikọ nke viral. nucleic acid.

Pharmacokinetics nke quercetin

N'okike, quercetin dị ka glucosides, na absorption nke quercetin glycosides nwere ike ịdịgasị iche dabere n'ụdị shuga agbakwunyere, quercetin glycosides (dị ka ndị a na-ahụkarị na yabasị ma ọ bụ anụ shallot) bụ ihe rutinoside ya (isi quercetin glycoside na tii). ) na-adị mfe itinye uche. A na-emezi glycosides nke ọma site na β-glucosidases dị na eriri afọ ntanye gaa n'ụdị aglycone ha, ọtụtụ n'ime ha na-emesị banye. Quercetin glucuronic acid na ihe ndị na-esi na sulfate na-enweta ahụ na-adị mfe karịa quercetin. N'ime ihe ndị na-emepụta quercetin, ụdị glycoside-conjugated dị mfe karịa quercetin. quercetin glycosides dị ọcha na-enwe ike imekọrịta ihe na ndị na-ebugharị glucose na-adabere na sodium na cell epithelial mucosal, ya mere, obere eriri afọ nwere ike ịbanye na vivo. Mgbe nnabata, quercetin na-metabolized na akụkụ dị iche iche gụnyere eriri afọ, eriri afọ, imeju na akụrụ, yana metabolites ya na-ekesa n'ime anụ ahụ dị iche iche. Enwere ike ịtụgharị Quercetin n'ime 3,4-dihydroxyphenylacetic acid, p-hydroxyphenylacetic acid, 3,4-dihydroxyphenylpropionic acid na p-hydroxyphenylpropionic acid site na nje nje eriri afọ mmadụ, mana ọnụego ntụgharị dị ala, nchịkwa ọnụ naanị ihe dị ka 20% na-etinye obi gị dum. tract digestive, 30% gbanwere, 30% na-apụkwa na nsị n'ụdị ọgwụ mbụ. Qurcetin na-etinye obi gị dum na-abanye ngwa ngwa na bile na mmamịrị n'ụdị glucuronate na sulfate n'ime awa 48. na-apụ apụ.

Usoro mmịpụta nke quercetin

1.Mwepụ na nkewa

Ebe ọ bụ na ọdịnaya nke quercetin dị na osisi dị ole na ole puku iri na puku iri na iri, na mmịpụta na nkewa siri ike ma ọnụ ahịa ya dị elu, ọ bụghị ihe bara uru iji wepụ quercetin ozugbo na osisi. Agbanyeghị, mgbe ị na-enyocha ma na-achọpụta flavonoids ma ọ bụ na-akwadebe ihe nlele dị ọcha, a ga-eji mmịpụta quercetin na usoro nkewa mee ihe.

2.Acid hydrolysis

A na-ekesa rutin (rutin) nke quercetin na okike ma nwee nnukwu ọdịnaya, dịka 20% na Sophora japonica. Wepụ rutin na Sophora japonica, wee mepụta quercetin mgbe acid hydrolysis gasịrị.

3.Enzymatic ntụgharị

N'iji ntụgharị enzymatic na hydrolyze rutin kwadebe nnukwu ego nke quercetin monomer na obere ọdịnaya na osisi, ọrụ ahụ dị mfe ma dị mma, usoro ahụ dum bụ nke akụ na ụba na nke bara uru, mmepụta dị ukwuu, ọ dịkwa mma maka mmepụta mmepụta ihe, na ịdị ọcha ngwaahịa karịrị 90%, nke nwere ike izute nri na ụlọ ọgwụ chọrọ. ngwa mkpa. Ya mere, ntụgharị enzymatic bụ ihe ịrụ ụka adịghị ya na usoro nkwadebe na-ekwe nkwa.

Mkpebi nke ọdịnaya quercetin

1. chromatography nke mmiri mmiri

Emere mkpebi ọdịnaya site na ịkwadebe quercetin ọkọlọtọ ngwọta, ule mmekọrịta linear, nkenke na ụkpụrụ usoro usoro ugboro ugboro.

2. HPLC usoro

Mkpokọta flavonoids akwadoro nke Sophora japonica gbazere ma kpochaa ya, a chọpụtakwara ọdịnaya nke quercetin dị na mkpokọta flavonoids dịka ọnọdụ chromatographic siri dị.

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