Chọpụta Ime Anwansi nke Piperine ntụ ntụ maka ahụike na ịdị mma gị

. Mmalite nke Piperine

piperine bụ alkaloid nke, yana piperine (chavicine, cis-trans isomer of piperine), bụ isi ihe na-eme ka ose ojii na-esi ísì ụtọ. A na-eji ya n'ụdị ụfọdụ ọgwụ ọdịnala yana ọgwụ ahụhụ. A na-emepụta ekpomeekpo ose na-esi ísì ụtọ nke capsaicin na piperine kpatara site na imeghe ọwa TRPV ion na nociceptors - ọwa TRPV-1 nke a na-eji achọpụta okpomọkụ na acidity. Na mgbakwunye, a chọpụtala piperine iji gbochie cytochrome P4503A4 (CYP3A4 maka mkpụmkpụ) na P-glycoprotein, enzymes abụọ dị mkpa na metabolism na ibufe xenobiotics na metabolites. Na ọmụmụ anụmanụ, ndị ọkà mmụta sayensị achọpụtala na piperine na-egbochikwa enzymes ndị ọzọ dị mkpa na metabolism ọgwụ. Site na igbochi metabolism ọgwụ, piperine nwere ike ịbawanye bioavailability nke ọtụtụ ogige. Dịka ọmụmaatụ, piperine mụbara bioavailability nke curcumin n'ime mmadụ nke ọma site na 2000%. N'ihi mmetụta ndị a na-egbochi ọgwụ na-emepụta ọgwụ, piperine kwesịrị iji nlezianya were ya site n'aka ndị ọrịa na-aṅụ ọgwụ iji zere mmetụta ndị dị na ya. Achọpụtara Piperine na 1819 site n'aka ọkà mmụta sayensị Danish Hans Oster.

. ntinye piperine

Piperine bụ anticonvulsant nke sara mbara, usoro kemịkalụ maka C17H19NO3. kristal monoclinic prismatic na-enweghị agba, enweghị isi, nwere mmetụta na-ere ọkụ mgbe ọ detụsịrị ọnụ. Anọpụ iche na litmus reagent. Soluble na chloroform, ethanol, ether, soluble na benzene na acetic acid, nke fọrọ nke nta ka ọ ghara ịsacha na mmiri na mmanụ ala ether [1]. Enwere ike ịwepụta ya na mkpụrụ osisi ose (Piper nigrum L.), ezinụlọ Piperaceae. Ọ nwere mmetụta mmegide dị mma na nnwale electroconvulsions na ụmụ oke, yana ogo dị iche iche na nhụsianya na-ama jijiji na ọdịdọ audiogenic kpatara site na pentylenetetrazol, toxin indohexadine, strychnine, na intracerebroventricular injections nke cylinder agatroine na glutamate. Ọ dịkwa irè n'ụdị ụfọdụ nke Akwụkwụ na-adọ. Piperine na-egbu egbu maka ijiji karịa pyrethrum.

.ịdị irè nke piperine

1. Njirimara antioxidant

Obere ose na piperine bụ isi na-arụsi ọrụ ike, nke na-enye ose na-esi ísì ụtọ, bụ antioxidants siri ike nwere ọrụ mkpochapụ na-enweghị isi. Mmanụ dị mkpa nke ose ojii nwekwara ọgaranya na phenolics, flavonoids na proanthocyanidins, nke niile nwere ihe ndị na-eme ka ahụ dị ike na-eme ka ahụ dị ike. Piperine bụkwa ihe mgbochi mkpali nke na-egbochi peroxidation lipid.

2. Nchekwa obi

ose ojii na-achịkwa metabolism lipid, mbufụt na steeti oxidative, nke niile na-emetụta ahụike obi, ebe piperine na-elekwasị anya na usoro metụtara atherosclerosis.

3. Nchekwa imeju

Piperine nwere mmetụta dị iche iche nke ọgwụ, gụnyere nchebe imeju. Nnyocha egosiwo na piperine nwere ike inye aka gbochie mmebi imeju nke tert-butyl hydroperoxide na kemịkalụ carbon tetrachloride kpatara site na ibelata peroxidation lipid.

4. Na-akwalite Absorption Nri

Oji ojii nwere ikike pụrụ iche nke na-arụ ọrụ synergistically na ọtụtụ nri nri, na-akwalite nnabata ha.

5. Immunomodulation

Piperine nwere ike igbochi mmepụta ụdị oxygen na-emeghachi omume, ma na-enyekwa aka ịbawanye ọdịnaya nke glutathione, ya mere o nwere ikike immunomodulatory.

Piperine nwere ọtụtụ ngwa eji eme ihe na ụlọ ọrụ nri, ọgwụ na ngwaahịa nlekọta ahụike:

1. Nri ụtọ: A na-eji piperine eme ihe n'ọtụtụ ebe iji tinye ekpomeekpo na ose na nri.

2. Ọgwụ: Piperine nwere antibacterial, mgbochi mkpali, analgesic na hemostatic Njirimara na-eji na ụfọdụ ọgwụ ọdịnala. A na-ejikwa ya eme mmanụ n'akụkụ maka ibelata nsogbu dị ka ogbu na nkwonkwo na mgbu ahụ.

3. Ụlọ ọrụ nri: Enwere ike iji piperine mee ihe na nhazi nri maka ịkwọ ụgbọ mmiri, isi nri na ịme anụ ahụ iji tinye ekpomeekpo na udidi na nri.

4. Ihe ịchọ mma: A na-ejikwa piperine eme ihe ịchọ mma, a pụkwara iji ya na-emepụta ihe eji elekọta anụ ahụ, ncha ntutu na ihe na-esi ísì ụtọ iji mee ka ngwaahịa ahụ na-esi ísì ụtọ, yana ịkwalite mgbasa ọbara na ịkwalite metabolism akpụkpọ ahụ.

N'ikpeazụ, piperine bụ ihe okike na nke dị irè nke nwere ọtụtụ ihe dị iche iche dị ka ịkwalite agụụ, inye aka mgbaze, meziwanye usoro ọbara, antioxidant, na imezi usoro iku ume. Ọ nwere ọtụtụ ngwa eji eme ihe na ụlọ ọrụ nri, ọgwụ na ngwaahịa nlekọta ahụike.

.ọnọdụ ahịa, atụmanya ahịa na mmepe ụlọ ọrụ nke piperine

1, Market Prospect

Piperine bụ alkaloid sitere n'okike, nke nwere mmetụta dị iche iche nke ọgwụ, dị ka mgbochi mkpali, antibacterial, antiviral, wdg. Ya mere, piperine nwere atụmanya ngwa ngwa na ngalaba ọgwụ. Ugbu a, piperine abanyela n'ọgba ule ụlọ ọgwụ. Piperine nwere mmetụta mgbochi mkpali, na ọrịa ndị na-efe efe dị ka ọrịa ogbu na nkwonkwo na osteoarthritis, piperine nwere ike belata mgbu na mbufụt. Na mgbakwunye, a na-eji piperine agwọ ọrịa ịba ọcha n'anya, AIDS na ọrịa ndị ọzọ. Ka ndị mmadụ na-etinyekwu uche na ahụike ha, ha nwere ihe dị elu chọrọ maka nrụpụta na nchekwa ọgwụ. Dị ka alkaloid sitere n'okike, piperine nwere nchekwa dị elu na ịdị irè, ya mere o nwere atụmanya ahịa sara mbara n'ọdịnihu.

2, Market ntụziaka

A na-atụ anya Piperine ka ọ bụrụ ọgwụ ọgwụgwọ ọhụrụ n'ọdịnihu ka ọ na-aga n'ihu na-aga n'ihu na ule ụlọ ọgwụ. Ọ bụrụ na piperine nwere ike ịgafe ule ụlọ ọgwụ ma nweta nkwenye, ọ ga-abụ ọgwụ ọgwụgwọ dị mkpa ma weta ozi ọma ndị ọzọ maka ndị ọrịa. N'ikpeazụ, piperine, dị ka alkaloid sitere n'okike nke nwere mmetụta dị iche iche nke ọgwụ ọgwụ, nwere ọtụtụ ngwa ngwa n'ọhịa nke ọgwụ. N'ọdịnihu, dị ka ule ụlọ ọgwụ na-aga n'ihu na-amụbawanye, a na-atụ anya na piperine ga-abụ ọgwụ ọgwụgwọ ọhụrụ ma na-ewetara ndị ọrịa uru karịa.

Ⅵ.Usoro nchọpụta maka piperine

1 chromatography oyi akwa

Chromatography oyi akwa bụ ụdị teknụzụ nnwale emepụtara n'afọ ndị na-adịbeghị anya maka nchọta, nkewa ngwa ngwa na njirimara. Ọ bụ nke chromatography adsorption siri ike. Chromatography oyi akwa nwere uru nke obere nlele, obere ihe mgbaze organic, nchọpụta ngwa ngwa na-enweghị mmetọ oge.

N'ihi na quantitative thin-layer chromatographic usoro nke piperine, a na-ekewa piperine nke ọma na GF254 silica gel plate with binary unfolding system of toluene: ethyl acetate: ethyl ether (6:3;1). Ogologo ahịrị ahịrị nke piperine bụ 15-75 ng, na mgbake ahụ bụ 94.53%, nke gosipụtara na a pụrụ iji usoro HPLC mee ihe dị ka ihe dị mfe, nyocha ngwa ngwa na usoro ọnụọgụ maka nchọpụta piperine.

2 chromatography nke mmiri mmiri

Liquid chromatography (HPLC) bụ otu n'ime ụzọ ndị tozuru oke maka ikpebi piperine. A na-ejikarị ya eme ihe n'ọhịa nke ịchọpụta ihe ndị na-emepụta ihe na-emepụta ihe na uru ya nke oke nkewa, izi ezi na ngwa ngwa. Ebe kachasị elu nke piperine gosipụtara mmekọrịta dị mma na ntinye uche na 3 ~ 150 g / mL na ọnụọgụ njikọ nke 0.999 4 Oke nke nchọpụta piperine bụ 1.2 g / mL, na ọdịnaya nke piperine na mkpụrụ osisi na-eto eto nke Piper. nigrum bụ 4.153 mg/g. Ọdịnaya nke piperine na mkpụrụ osisi tozuru oke nke Piper nigrum bụ 27.2 mg/g. Piperine adịghị n'ime ifuru Piper nigrum. A na-eji chromatography mmiri na-arụ ọrụ dị elu (RP-HPLC) mee ihe maka ikpebi piperine na Piper nigrum, na kọlụm chromatographic bụ kọlụm Luna C18 (250 mm * 4.60 mm, 5 & mu; m) nwere usoro mkpanaka nke methanol. : mmiri (77:23) na ọsọ ọsọ nke 1.0 ml / min. Ogologo ebili mmiri chọpụtara bụ 343 nm yana okpomoku kọlụm bụ 35C.

3 Capillary electrophoresis

Capillary electrophoresis bụ usoro nyocha nkewa nkewa nke electrophoretic na-eji capillary quartz na-agbanwe dị ka ọwa nkewa na ọkụ eletrik dị ugbu a dị elu dị ka ihe na-eme ka ọ ghọta nkewa dabere na ọdịiche dị na mmegharị na nkesa nkesa n'etiti ihe ndị dị na ihe atụ. A na-eji ya rụọ ọrụ nkewa dị elu, oke ọsọ, oke uche, ihe nlele dị ala na ọnụ ala dị ala.

Achọpụtara ọdịnaya nke piperine na ose ọcha site na obere tube electrophoresis. Ọnọdụ electrophoresis bụ ndị a: kọlụm capillary quartz (50 um * 90 cm, ogologo n'ezie 81.5 cm), ihe nchekwa 0.02 mol / L Na2HPO4, 0.02 mol / L NaH2PO4 = 95: 5 (pH = 8.6 na 16 & deg;C), nkewa. voltaji 28 kV, ntụtụ nrụgide 30 mbar * 8 s, okpomọkụ 25.C, okpomọkụ = 0.05 & mu;mol / L Na2HPO4, pH = 0.5 & mu;mol / L NaH2PO4. The nkewa voltaji bụ 28kV, mgbali injection 30 mbar * 8 s, okpomọkụ 25.C, nchọpụta wavelength 343 nm.

4 Ultraviolet spectrophotometry

Ultraviolet spectrophotometry bụ usoro na-eji ụdị dị iche iche absorption nke piperine n'ihi mgbanaka benzene na njikọ njikọ abụọ na nhazi nke piperine. Enwere ike iji ọdịdị nke piperine nke na-etinye ìhè ultraviolet maka ikpebi piperine. Ihe ngwọta ethanol nke piperine nwere ọnụ ọgụgụ kachasị elu nke absorption na 342 nm na mpaghara UV spectral, na a na-eji ọnụ ọgụgụ a mee ihe iji guzobe usoro maka ikpebi piperine site na UV spectrophotometry. Enwere ike iji usoro a chọpụta piperine na ntinye uche nke 0 70 g/mL, nke na-erube isi n'iwu Beale. Otú ọ dị, alkaloids ndị ọzọ dị ka piperine, piperitinine, na ihe ndị ọzọ nwere ụkpụrụ absorption na ogologo oge a nwere ike igbochi nsonaazụ ya, nke mere na ọdịnaya piperine nke UV spectrophotometry kpebiri na-adịkarị elu karịa ezigbo uru.

5 Polarization

Ebe ọ bụ na piperine nwere C = C abụọ na ọnọdụ acidic nwere ike ịbụ na mmeghachi omume mbelata mercury drop electrode, na-ebute ọnụ ọgụgụ polar. Piperine na-emepụta ọnụ ọgụgụ polar nwere mmetụta na Britton-Robinson ngwọta na pH 2.2 gburugburu -1.01 V (vs. SCE).

Akpụkpọ ụkwụ na-ejikọta ọnụ n'etiti ọnụ ọgụgụ kasị elu ugbu a na ntinye nke piperine dị na 0.05 8 g/mL. Nsonaazụ gosiri na mkpebi siri ike nke piperine site na polarography dị mfe, ngwa ngwa na mmetụta. Otú ọ dị, n'ihi nsi nke mercury vapors na mercury droplet electrodes na oxidation nke mercury electrodes n'ụzọ dị mma, ohere nke ngwa nke polarography na-adịwanye ntakịrị.

Polarization.jpg

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