Chọpụta uru ahụike nke Troxerutin: Antioxidant eke siri ike

Ⅰ,Okwu mmalite nke troxerutin

Troxerutin bụ ngwakọta organic nwere usoro kemịkalụ C33H42O19. A na-ejikarị ya dị ka ọgwụ nchebe capillary. Troxerutin bụ odo, odo-acha akwụkwọ ndụ akwụkwọ ndụ ma ọ bụ ntụ ntụ ntụ ntụ; enweghị isi, ntakịrị nnu na uto; hygroscopic. Ngwaahịa a na-agbaze ngwa ngwa n'ime mmiri, na-agbaze ntakịrị na methanol, soluble dị ntakịrị na ethanol, yana chloroform na-adịghị ike. Troxerutin bụ ihe soluble mmiri nke rutin, nke nwere quercetin yiri rutin, ebe quercetin na glycosides ndị ọzọ (dị ka rutin, hyperoside wdg) niile nwere mmetụta analgesic dị n'etiti na nke dị n'akụkụ, yana usoro analgesic ha metụtara ibelata calcium. ion ọdịnaya nke ụjọ anụ ahụ.

Ⅱ,Mmetụta nke troxerutin

Troxerutin nwere ike igbochi nchịkọta platelet ma gbochie thrombosis. N'otu oge ahụ, ọ nwere ike iguzogide mmebi vaskụla nke 5-hydroxytryptamine na bradykinin na-akpata, na-eme ka nkwụsị nke capillary dịkwuo elu, belata nkwụsị nke capillary, ma gbochie edema nke na-eme ka ọkpụkpụ vaskụla dịkwuo elu. Ọ nwere mmetụta nchebe dị ukwuu na nnukwu mmerụ ahụ ụbụrụ ischemic.

Ngwa nke troxerutin

Troxerutin nwere ike igbochi nchịkọta platelet ma gbochie thrombosis. N'otu oge ahụ, ọ nwere ike iguzogide mmebi vaskụla nke 5-hydroxytryptamine na bradykinin na-akpata, na-eme ka nkwụsị nke capillary dịkwuo elu, belata nkwụsị nke capillary, ma gbochie edema nke na-eme ka ọkpụkpụ vaskụla dịkwuo elu. Ọ nwere mmetụta nchebe dị ukwuu na nnukwu mmerụ ahụ ụbụrụ ischemic.

Troxerutin nwere ike ịbawanye nguzogide nke capillaries, belata ikike nke capillaries, ma belata nsogbu nke ịcha ọbara ọbara. Troxerutin nwere mmebi ihe na-egbochi ọkụ ọkụ yana mmetụta nfụkasị ahụ, enwere ike ịgbakwunye ya na ihe ịchọ mma sunscreen iji mezie ntachu anụ ahụ nke radieshon ultraviolet kpatara. N'otu oge ahụ, ọ pụkwara n'ụzọ doro anya na-ewepụ oxygen free radicals na-arụ ọrụ nke mkpụrụ ndụ, nọgide na-enwe nkịtị metabolism nke mkpụrụ ndụ, na mmetụta ya dị nnọọ ukwuu karịa nke vitamin E.

A na-ejikarị Troxerutin eme ihe na mkpuchi anwụ na ihe ịchọ mma na-egbochi ihe nfụkasị ahụ, dị ka ude mmiri, ude mmiri, ihe kacha mkpa, nkpuchi, mkpuchi anwụ, ihe nhicha ihu, wdg.

Ⅳ, Ọrụ nke Troxerutin na ịchọ mma:

1. Antioxidant

Troxerutin nwere ihe antioxidant siri ike nke nwere ike inye aka belata mmebi akpụkpọ ahụ site na ụzarị UV na mmetọ. Ihe ndị a na-emerụ ahụ nwere ike iduga ịka nká akpụkpọ ahụ, mwepu agba, nkwụsị nke ịdị nro na luster. Troxerutin nwere ike ichebe mkpụrụ ndụ akpụkpọ ahụ site na ihe ndị a na-emerụ ahụ site n'iwepụ radicals efu, na-eme ka akpụkpọ ahụ dịkwuo mma ma na-eto eto.

2. Onye na-acha ọcha

A na-ejikwa Troxerutin mee ihe n'ọtụtụ ebe dị ka ihe na-acha ọcha. Ọ nwere ike igbochi ọrụ tyrosinase, si otú a na-ebelata mmepụta nke melanin. Melanin bụ otu n'ime isi ihe na-eme ka akpụkpọ ahụ gbaa ọchịchịrị. Site n'iji ngwaahịa ịchọ mma nwere Triclopyr, mmepụta nke melanin nwere ike ibelata, na-eme ka ọ dịkwuo ọkụ na ọbụna akpụkpọ ahụ.

3. Kwalite akpụkpọ cell ọhụrụ na mmezi

Troxerutin nwere ike ịkwalite mmeghari na mmezi nke mkpụrụ ndụ akpụkpọ ahụ. Ọ nwere ike ịkpali mmepụta nke collagen, nke bụ akụkụ dị mkpa nke nrịcha akpụkpọ ahụ na ihe na-egbuke egbuke. Site n'iji ngwaahịa ịchọ mma nwere tretinoin, ọ nwere ike inye aka weghachite ahụ ike nke akpụkpọ ahụ, si otú a na-eme ka ọ dị obere ma na-egbuke egbuke.

4, na-ebelata mbufụt akpụkpọ na allergies

Troxerutin nwekwara mmetụta mgbochi mkpali na mgbochi mkpali. Ọ nwere ike belata nsogbu ndị dị ka mbufụt akpụkpọ na allergies. Ọ bụrụ na akpụkpọ ahụ gị na-enwekarị ọbara ọbara, itching ma ọ bụ nsogbu dịka eczema, iji ihe ịchọ mma nwere tretinoin nwere ike inye aka belata ahụ erughị ala ndị a.

Ⅴ, Otu esi eji troxerutin mee ihe n'echiche

A ghaghị iji ọgwụ mee ihe n'ụzọ ezi uche dị na ya ma zere mmegbu. Ekwesịrị ka dọkịta depụta ọgwụ ndenye ọgwụ, yana ọgwụ ndị a na-ere ahịa kwesịrị ịgụ nke ọma ihe ntinye ngwugwu.

Troxerutin bụ ọgwụ ndenye ọgwụ yana dọkịta ga-ederịrị ya dabere na ọnọdụ gị. Ọgwụ onwe gị nwere ike ịbawanye ohere nke iji ọgwụ na-enweghị isi: imefusị akụ ọgwụ, igbu oge ọnọdụ gị, ịzụlite nguzogide ọgwụ, na ịkpata mmeghachi omume ọgwụ ọjọọ.

Ọ dị mkpa ka etinye Troxerutin n'ụzọ zuru oke yana maka usoro ọgwụgwọ zuru oke. Enwere ike belata ihe mgbaàmà gị tupu a chịkwaa ọrịa ahụ kpamkpam, mana ị nweghị ike ibelata usoro onunu ogwu ma ọ bụ kwụsị ọgwụ ahụ n'ụzọ dị mfe iji zere mmepe nke nguzogide ọgwụ, nlọghachi ma ọ bụ ka njọ nke ọrịa ahụ ọzọ.

Ⅵ, Usoro nkwadebe nke Troxerutin

Usoro nkwadebe nke triclopyr dị ọcha dị elu, nke e ji mara na ọ gụnyere usoro ndị a.

1. A na-agwakọta synthesis nke triclopyr, rutin na catalyst n'otu n'otu ma tinye ya na reactor dị elu, ethylene oxide na-agafe n'ime methanol wee wụsa ya n'ime onye na-eme ihe na-eme ka ọ dị elu, a na-emechi onye na-eme ihe ike, a na-achịkwa nrụgide mmeghachi omume. na-adịghị elu karịa 0.5MPa, mmeghachi omume okpomọkụ bụ 50-80°C, mmeghachi omume na-akwụsị mgbe ọdịnaya nke trihydroxyethyl rutin bụ nke kasị elu site HPLC sampling na nlekota oru, na mmeghachi omume na-edozi na hydrochloric acid na a pH nke. 5-6 na mgbe ahụ Cooling crystallization na filtration ma ọ bụ tụgharịa evaporation nke methanol iji nweta triclopyr, kwuru na-akpalite bụ sodium methanol ma ọ bụ sodium ethanol, na uka ruru rutin ka catalyst bụ 10-15: 1, oke rutin ka ethylene oxide bụ. 3-4: 1, na dose nke methanol volumetric bụ ugboro 3-5 nke oke rutin;

2. Nnụcha nke triclopyr, ndị jụrụ crystallization mmịpụta ma ọ bụ spinning methanol iji nweta triclopyr na-akpali n'ime mmịpụta crystallization reactor, nke mere na ọ bụ na ala njedebe nke crystallization etiti, mechie outlet valvụ, ọ dịghị elu karịa eruba ọnụego nke. 2L / min na mmịpụta crystallization reactor n'ime C02 ruo mgbe nrụgide ruru 6-10MPa, a na-etinye okpomọkụ na 50-80 & deg; C, na-akpali akpali na ọsọ nke 350 r / min, l-3h Mgbe ntọhapụ nke CO2, na Mbelata CO2 crystallization efere ọdịda nke elu ịdị ọcha Troxerutin.

Ⅶ, njirimara nke Troxerutin

1. Were ihe dị ka 20mg nke ngwaahịa a, tinye 20ml mmiri, 1ml nke hydrochloric acid na obere ego nke zinc ntụ ntụ, kpo oku na mmiri ịsa ahụ, na-egosi agba uhie na-adịgide adịgide.

2. Were ihe dị ka 20mg nke ngwaahịa a, tinye 20ml mmiri na obere trichloride aluminum, ihe ngwọta na-egosi na-acha odo odo.

3. Were ngwaahịa a, tinye mmiri iji mee ngwọta nwere 20μg kwa 1ml, dị ka usoro spectrophotometric si dị (Chinese Pharmacopoeia 2000 version nke akụkụ nke abụọ nke Ihe Mgbakwunye ⅣA), enwere oke absorption na wavelengths nke 254nm na 347nm. , na enwere mmịpụta kacha nta na ogologo wavelength nke 283nm.

Ⅷ,Atụmanya mmepe nke ụlọ ọrụ troxerutin

Troxerutin maka ịgba ogwu bụ otu n'ime ngwaahịa kachasị na mpaghara obi. Nkwadebe nke Troxerutin bụ ọgwụ mgbochi ọbara na thrombolytic nkịtị na omume ụlọ ọgwụ ma tinye ya na katalọgụ mkpuchi mkpuchi ahụike nke mba. Isi ọrụ ya bụ igbochi nchịkọta nke mkpụrụ ndụ ọbara uhie na platelet, gbochie ịmepụta thrombus, ịbawanye ọdịnaya oxygen ọbara, meziwanye microcirculation, iguzogide mmebi vaskụla nke serotonin na bradykinin kpatara, na ịbawanye nguzogide nke capillaries. Isi ihe na-egosi ya bụ ọgwụgwọ ischemic cerebrovascular ọrịa, thrombophlebitis, Central retinitis, varicose veins, arteriosclerosis, ọrịa obi obi, wdg.

Enwere ọtụtụ ụlọ ọrụ na ụlọ ahịa nkwadebe troxerutin, ndị isi egwuregwu gụnyere Anhui Hongye, Ruiyang Pharmaceutical, Jilin Jinsheng, wdg. Ụlọ ọrụ ndị a kpọtụrụ aha n'elu na-akwụ ụgwọ maka oke ahịa nke troxerutin maka injection n'ụlọ ọgwụ ọha. A na-ekewa nkwadebe troxerutin akwadoro na obodo m n'ụdị injection, ụdị mbadamba, ụdị ngwọta na ụdị capsule, na ụdị ịgba ọgwụ na-eburu isi ahịa ahịa. Site na 2015 ruo 2023, ire nke nkwadebe troxerutin na ụlọ ọgwụ ọha na mba m ga-aga n'ihu na-eto eto.

Atụmanya mmepe nke troxerutin industry.jpg

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