Paeoniflorin ntụ ntụ

Usoro nchọpụta: HPLC
CAS: 23180-57-6
Usoro molecular: C23H28O11
Onu ogugu oke: 480.47
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Kedu ihe bụ paeoniflorin?

Paeoniflorin na albiflorin (nke a makwaara dị ka paeoniflorin, albiflorin) bụ monoterpene glycosides nke a na-ahụkarị na osisi Paeoniaceae ma bụrụ ihe ndị bụ isi na ọgwụ ndị China ọdịnala na-acha ọcha peony mgbọrọgwụ, mgbọrọgwụ peony uhie na ogbugbo peony. Ihe ndị na-arụ ọrụ na ụkpụrụ njikwa mma, nwere mmetụta na ojiji dị iche iche nke ọgwụ. Mkpokọta glycosides bụ ọgwụ maka ọgwụgwọ ọrịa ogbu na nkwonkwo na China. Enwere ike iji Paeoniflorin na paeoniflorin dị ka ihe na-arụsi ọrụ ike na ọgwụ na ọrụ ndị metụtara ya. ubi nri.


Paeoniflorin ntụ ntụ bụ isi ihe na-arụ ọrụ nke Paeoniae Radix Alba, Paeoniae Radix Rubra na Paeonia suffruticosa Andr. Ọ bụ monoterpene glycoside nke na-agbaze mmiri nke e bu ụzọ wepụta na peony na 1963. Paeoniflorin anaghị eguzosi ike na kemịkalụ na ọ dị mkpa ka echekwara ya na obere okpomọkụ, ebe oyi kpọnwụrụ, ma zere ebe alkaline. Paeoniflorin nwere mmetụta dị iche iche dị ka ịhịa aka n'ahụ, mgbochi mkpali, analgesia, na mmụba nke ikike ọgụgụ isi. A na-eji ya n'ọtụtụ ebe na ọgwụgwọ ụlọ ọgwụ na nyocha bụ isi nke ọrịa akwara na ọrịa neurodegenerative dị ka ọrịa Alzheimer, ọrịa strok, ịda mbà n'obi, Akwụkwụ na-adọ, wdg. Nnyocha na mmetụta ọgwụ nke paeoniflorin na antidepressant, mgbochi mkpali, analgesic, hepatoprotective, neuroprotective, immunomodulatory, mgbochi na ọgwụgwọ nke nsogbu ọrịa shuga na mmetụta ọgwụ ndị ọzọ nwere ọganihu dị ukwuu. Ọganihu nyocha na nsonaazụ ọgwụ nke paeoniflorin n'ime afọ atọ gara aga ka edoziri wee chịkọta ya iji nye ntụaka maka mmepe n'ihu na ngwa ụlọ ọgwụ nke paeoniflorin.

Paeoniflorin

Olee uru?

1. Mmetụta Antioxidant: Ọ nwere ike ịzọpụta radicals efu, belata mmebi oxidative, ma chebe akpụkpọ ahụ pụọ na ihe ndị metụtara gburugburu ebe obibi dị ka ụzarị ultraviolet na mmetọ.

2. Mmetụta mgbochi mkpali: Ọ nwere ike igbochi mmeghachi omume mkpali ma belata mgbaàmà nke mbufụt akpụkpọ anụ dị ka ọbara ọbara, ọzịza, na itching.

3. Kwalite njikọ collagen: Ọ nwere ike ịkwalite njikọ nke collagen ma mee ka akpụkpọ ahụ dịkwuo mma na nkwụsi ike.

4. Na-egbochi mmepụta nke melanin: Ọ nwere ike igbochi mmepụta nke melanin ma belata ọnọdụ nke ọrịa akpụkpọ anụ dị ka ntụpọ na freckles.

5. Mmetụta moisturize: Ọ nwere ike ime ka mmiri dị n'ime akpụkpọ ahụ dịkwuo elu, mee ka ikike ijide mmiri nke akpụkpọ ahụ dịkwuo mma, mee ka akpụkpọ ahụ dịkwuo nro ma dị nro.

6. Mmetụta mgbochi mkpali

Ndị nchọpụta oge mbụ chọpụtara na paeoniflorin gbochiri okwu chemokine mRNA nke ọma na mkpụrụ ndụ dermal microvascular endothelial cell (HMEC-1) nke TNF-a na-ebute ma belata ihe nzuzo nke chemokines na omenala dị elu; ha chọpụtakwara na paeoniflorin gbochiri idegharị ihe nuklia. A na-ebuga Factor-κB (NF-κB) gaa na nucleus, na-egosi na paeoniflorin nwere ikike mgbochi iji gbochie mmepụta chemokine nke TNF-α na-ebute na mpụ leukocyte, na usoro ya metụtara igbochi ụzọ NF-κB na ERK. . E gosiputara na paeoniflorin nwere mmetụta mgbochi mkpali na vitro ma enwere ike iji ya dị ka onye na-achọ ọgwụ maka ọgwụgwọ ọrịa akpụkpọ anụ.

7.Analgesic mmetụta

Paeoniflorin nwere mmetụta analgesic, nke na-abụghị nanị dị irè mgbe ejiri ya na benzoylaconitine, ma nwekwara uru dị mkpa na ọgwụgwọ onwe nke ụdị mgbu dị iche iche. Nnyocha achọpụtala na mmetụta analgesic nke paeoniflorin nwere ike jikọta na mmụba nke ọkwa β-endorphin (β-EP) na serum na cerebral cortex na mbelata mmepụta ma ọ bụ ntọhapụ nke prostaglandin E2 (PGE2) na ụbụrụ ụbụrụ.

8. Ọrụ nchedo ahụ

1 Mmetụta nchebe megide mmebi imeju

Nnyocha ndị gara aga achọpụtala na paeoniflorin nwere mmetụta ọgwụgwọ ụfọdụ na ọrịa imeju na-abụghị mmanya na-aba n'anya, mmerụ ahụ imeju kemịkalụ, mmerụ ahụ imeju radieshon, mmerụ ahụ na-egbu egbu nke imeju, mmerụ ahụ ischemia-reperfusion imeju na ọrịa ndị ọzọ, mana usoro omume edobeghị anya. afọ ndị na-adịbeghị anya. Enwere ike ịkọwa ya ọzọ, tumadi na akụkụ nke igbochi ihe ndị na-akpasu iwe, na-achịkwa nrụgide mgbochi oxidative, na-achịkwa mgbochi na mgbochi apoptosis. Achọpụtara na paeoniflorin nwere ike ibelata ọkwa aspartate aminotransferase (AST) na alanine aminotransferase (ALT) na serum ụmụ oke, ma nwee mmetụta nchebe na mmebi imeju nke lipopolysaccharide kpatara. Nnyocha achọpụtala na paeoniflorin nwere mmetụta nchebe na carbon tetrachloride na-ebute nnukwu mmerụ ahụ imeju na fibrosis imeju. Usoro ahụ nwere ike jikọta ya na mbenata apoptosis hepatocyte, nrụgide oxidative, ibelata mmepụta cytokine pro-inflammatory, na ịkwalite heme oxygenase-1 metụtara okwu ahụ.

2 Neuroprotective mmetụta

Paeoniflorin ntụ ntụ nwere mmetụta nchebe doro anya na neurons, neurotoxicity na mmebi mkpụrụ ndụ akwara. Nnyocha n'ime afọ 2 gara aga akọwakwuola usoro omume a. Nnyocha achọpụtala na paeoniflorin na-egbochi Aβ (1-42) -mkparịta ụka oxidative na-akpata na hippocampal neuron mebiri na oke AD site n'ịkwalite NF-E2 metụtara 2 / ARE regulatory gene (Nrf2 / ARE) ụzọ. Achọpụtara na paeoniflorin nwere ike belata mfu nke neurons nke tributyltin chloride (TBTC) kpatara wee gbanwee mbelata protein kinase na-arụ ọrụ mitogen (MAPK) na ọkwa JNK site na igbochi ọrụ protein kinase (JNK) na-arụ ọrụ. Tụkwasị na nke ahụ, a chọpụtara na paeoniflorin nwere ike igbochi ma ọ bụ na-agwọ ọrịa neurodegenerative na mmebi irighiri akwara site na igbochi mitogen-activated protein kinase kinase-4 (MKK4) -JNK ụzọ akara.

9. Mmetụta immunomodulatory

Nnyocha mbụ achọpụtala na mkpokọta glycosides nke paeony nwere mmetụta ọgwụgwọ na ọrịa autoimmune dị ka ọrịa ogbu na nkwonkwo na sistem lupus erythematosus. N'ime afọ abụọ gara aga, akwụkwọ akụkọ na-akọ na paeoniflorin bụ isi ihe na-emepụta mmetụta immunomodulatory. Site n'inyocha mmetụta nke paeoniflorin na phenotype na ọrụ nke mkpụrụ ndụ dendritic (DCs), anyị chọpụtara na paeoniflorin nwere ike igbochi maturation na ọrụ nke DCs, na-enye ihe ndabere maka ọgwụgwọ ọrịa autoimmune na paeoniflorin. Achọpụtara Paeoniflorin iji belata lipopolysaccharide (LPS) -induced phosphorylation nke interleukin receptor 1-related kinase 1 (IRAK 1) na protein ya dị ala, ma gbochie okwu TNF-α na IL-6. Nke a na-egosi na paeoniflorin na-egbochi ịgbalite cell LPS site na igbochi ụzọ IRAK 1/NF-κB na macrophages nke ụmụ oke MRL/LPR, ma nwee ike bụrụ ọgwụgwọ nwere ike ịgwọ ọrịa autoimmune systemic lupus erythematosus. Nsonaazụ ndị a na-egosi na paeoniflorin nwere mmetụta immunomodulatory abụọ.

10.Other ọrụ

Na mgbakwunye, Paeoniflorin ntụ ntụ nwekwara mmetụta ọgwụ ọgwụ dị ka imeziwanye ụra, antioxidant, na-achịkwa lipids ọbara, na mbelata ọkwa estrogen na cortex ụbụrụ nke ọrịa premenstrual.

Paeoniflorin

Onye na-eweta Paeoniflorin

Yuantai Organic Bio na-agba mbọ inye ndị ahịa ihe kacha mma Paeoniflorin ntụ ntụ na ọrụ ka onye ọ bụla na-azụ ahịa nwee ike ịnụ ụtọ nri eke, ahụike yana oke mma. Ọ bụrụ na ị nwere ajụjụ ọ bụla ma ọ bụ mkpa gbasara ngwaahịa anyị, biko nweere onwe gị ịkpọtụrụ anyị, anyị ga-azaghachi gị ozugbo enwere ike.

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