Naringin ntụ ntụ

Nkọwa: 98%
Usoro nchọpụta: HPLC
CAS: 480-41-1
Usoro molecular: C15H12O5
Onu ogugu oke: 272.25
EINECS: 207-550-2
Mbupu ọsọ: 1-3 ụbọchị
Ngwaahịa: Ọ dị na ngwaahịa
Asambodo: HACCP, HALAL, KOSHER, ISO9001, ISO22000, FDA
MOQ: 25KG
Ngwugwu: 25kg / gbọmgbọm
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Kedu ihe bụ naringenin?

Naringenin ntụ ntụ (naringenin) bụ ihe okike sitere n'okike nwere usoro molekụla C15H12O5. Ọ bụ ntụ ntụ edo edo, soluble na ethanol, ether na benzene. tumadi si Anacardiaceae osisi cashew akụ bụ mkpụrụ mkpuchi, wdg. Eji qualitative na quantitative analysis nke omenala Chinese ọgwụ nwere naringenin. Ọ na-etolite glycoside na neohesperidin na ọnọdụ 7-carbon, nke a na-akpọ naringin ma nwee uto dị oke ilu. Mgbe a na-emeghe ya na hydrogenated n'okpuru ọnọdụ alkaline iji mepụta dihydrochalcones, ọ bụ ihe na-atọ ụtọ na-atọ ụtọ ruo ugboro 2000 nke sucrose. A na-ahụ Hesperetin nke ukwuu na peels citrus. Ọ na-etolite glycoside na rutose na ọnọdụ 7-carbon, nke a na-akpọ hesperidin. Ọ na-etolite glycoside na β-neohesperidin na ọnọdụ 7-carbon, nke a na-akpọ neohesperidin.

Naringin ntụ ntụ bụ aglycone nke naringin ma bụrụ ihe mejupụtara dihydroflavone. Ọ bụ agịga ọcha dị ka kristal (methanol) n'ime ụlọ okpomọkụ. Ọ bụ soluble na ethanol, ether na benzene, na ọ fọrọ nke nta ka ọ ghara ịsacha ya na mmiri. Mmeghachi omume nke magnesium hydrochloride ntụ ntụ bụ cherry red, mmeghachi omume nke sodium tetrahydroborate bụ ọbara ọbara na-acha odo odo, na mmeghachi omume molish adịghị mma. N'okike, ọ na-esite na buds ifuru nke osisi rose Sakura (Prunusyedoensis Mate.) na isi shei nke mkpụrụ osisi nke osisi Anacardiaceae (Amacardi-umoccidentale L.). Akụkụ bụ isi nke flavonoids yiri ya, na ọtụtụ n'ime ihe ndị ahụ adịghị mma na abụba solubility na mmiri solubility, ma nwee obere bioavailability. Site n'ịgbanwe nhazi ya na iwebata ìgwè ndị nwere ike ime ka abụba ma ọ bụ mmiri na-edozi ahụ, enwere ike imeziwanye abụba-soluble ma ọ bụ mmiri-solution, si otú ahụ meziwanye bioavailability. Ngbanwe nhazi ya gụnyere alkylation, acylation, sulfonation, glycoside na nguzobe nke igwe igwe nke otu hydroxyl.

Olee uru?

1. Mmetụta mgbochi mkpali

Nzaghachi na-egbuke egbuke na-ezo aka na nzaghachi nchebe nke anụ ahụ na ihe ndị na-emebi emebi. Ọ bụ usoro dị mgbagwoju anya gụnyere cytokines dị iche iche. Nnwale mgbochi nje chọpụtara na naringenin gosipụtara ezigbo ọrụ antibacterial megide Escherichia coli, Staphylococcus aureus na Bacillus subtilis. Usoro nke naringenin na-eme ka lipopolysaccharide (LPS) na-eme ka ọ bụrụ nke ọma na-eme ka ọ bụrụ na ọ na-eme ka ọ ghara ịmịnye cell cell infiltration, ntọhapụ nke ndị mgbasa ozi na-egbuke egbuke, pulmonary edema, MPO, na iNOS ọrụ site na NF-κB ụzọ, ma gbochie nzuzo nke TNF-α. na mbufụt nke akpa ume. Neutrophil infiltration na-ebelata nnabata neutrophil na ngụgụ na mmebi oxidative nke neutrophil na-eme ka ọ bụrụ ihe na-akpata, na ọmụmụ ihe ndị a akwalitewo mmepe nke naringenin dị ka onye na-egbochi mkpali.

2. Mmetụta antioxidant

Ọ nwere ike igbochi nrụgide oxidative n'ime imeju, nke nwere ike jikọta ya na ntinye nke Nrf2 transcription factor na nkwụsị nke ụzọ TNF-α nke na-eme ka mmeghachi omume na-egbuke egbuke na anụ ahụ imeju. Nhazi kwesịrị ekwesị n'etiti oxidants na antioxidants dị mkpa maka ahụike na ogologo ndụ. Ozugbo nguzozi ahụ mebiri emebi, ọ nwere ike ibute arụ ọrụ na ọrịa nke nrụgide oxidative kpatara. Ekwenyere na nrụgide oxidative na-ekere òkè na pathogenesis nke ọrịa shuga na nsogbu ya. N'ụzọ dị mkpa, naringenin nwere ike ibelata ọrịa shuga na nsogbu ndị metụtara ya, nke nwere ike jikọta ya na ikike ya igbochi ụzọ mkpali na akara cell, chebe cytokines na-egbuke egbuke, na ịkwalite mmetụta antioxidant.

3. Mgbochi mmebi mmetụta

Mmerụ ahụ na-ezo aka na mbibi nke ihe owuwu anụ ahụ kpatara site na ihe dị iche iche na-akpata traumatic (dị ka ọrịa siri ike, trauma, ujo, ọla arọ na-egbu egbu, wdg), na mmeghachi omume mpaghara na usoro. Naringenin nwere mmetụta nchebe na mmebi nke ndu ma na-enye ntụziaka nyocha maka ọgwụgwọ nke mmebi nke ọla dị arọ na-egbu egbu kpatara. Ewubere ụdị mmerụ ahụ siri ike (ALI) site na ntinye nke lipopolysaccharide (LPS), na doses dị iche iche nke naringenin ka agbanyere intraperitoneal. Nchọpụta nke ihe ndị metụtara ya na bronchoalveolar lavage fluid gosiri na naringenin nwere ike igbochi TNF-α, TGF-β1, Ntugharị nke ọkwa MMP-9 na TIMP-1 na-ebelata ọdịnaya nke malondialdehyde na hydroxyproline na ngụgụ, ma na-abawanye ọrụ ndị ahụ. nke SOD, GSH-Px, na HO-1, na-egosi na naringenin nwere ike ichekwa ma gwọọ ALI nke ọma. , na-enye echiche ọhụrụ maka ọgwụgwọ ahụike nke mmerụ ahụ nku ume.

4. Mmetụta hypolipidemic

Hyperlipidemia na-ebutekarị site na oke cholesterol (TC), triglycerides (TG) na obere njupụta lipoprotein (LDLC) na plasma. Ọ bụ ọrịa a na-ahụkarị nke na-eyi ahụike mmadụ egwu nke ukwuu, ọnụ ọgụgụ ọ na-ebute na-abawanye kwa afọ. . Ọ bụ ezie na statins na fibrates dị irè, ha nwere ọtụtụ mmetụta. Ya mere, ndị mmadụ egosila mmasị dị ukwuu na mmetụta lipid-eweda ọbara nke ọgwụ ọdịnala ndị China. Nnyocha e mere achọpụtala na flavonoids dị ka naringenin nwere ike ibelata mkpokọta CH na TG n'ime ọbara site na igbochi apolipoprotein B nke imeju zoro ezo, si otú ahụ na-enweta mmetụta nke iwetulata lipids ọbara. Naringenin nwekwara ike igbochi ọrụ HMGCoA reductase, belata ọkwa lipid ọbara na ụdị oke oke hyperlipidemia, kwalite metabolism lipid na-adịghị mma na oke oke nwere hyperlipidemia, ma gbochie nguzobe nke atherosclerosis na imeju abụba abụba.

5. Antibacterial, antifungal na antiviral

Naringenin nwere mmetụta antibacterial megide Staphylococcus epidermidis, Staphylococcus aureus, Bacillus subtilis, Xanthococcus na Escherichia coli. Ọmụmụ ihe ndị ọzọ agbakwunyela ihe akaebe maka Lactococcus lactis, Lactobacillus acidophilus, Actinomyces naeslundii, Prevotella oralis, Lactobacillus acidophilus, Propionibacterium melanogaster, Porphyromonas gingivalis, na Candida albicans, okpomọkụ na nje bacteria Gram-adịghị mma. Ihe akaebe maka ndị na-egbu nje dị ka Candida flexi. Ọ bụ ezie na egosibeghị naringin nwere mmetụta mgbochi ọ bụla na ọrụ urease nke microorganisms, enwere ihe akaebe nke mmetụta nje na-egbu ya megide Helicobacter pylori.

Naringenin nwere ike ibelata mmepụta nje na hepatocytes nke HCV butere na vitro. Nke a nwere ike ịbụ nke abụọ na mmetụta naringenin na igbochi nzuzo VLDL. Mmetụta antiviral nke naringin dị ugbu a na ọmụmụ ụlọ ọgwụ. Ebipụtawokwa akụkọ banyere mmetụta mgbochi nje na poliovirus, HSV-1 na HSV-2, n'agbanyeghị na egbochighị nje virus.

6.Immunomodulatory

Naringin ntụ ntụ na-edobe nguzozi oxidative na-agafeghị oke n'ime cell n'otu oge na mpaghara akọwapụtara site na ịhazigharị nke electrons na mitochondria. Ya mere, ọrụ immunomodulatory nke naringenin dị iche na omenala dị mfe nkwalite mgbochi ma ọ bụ immunosuppressants. A na-eji ya mara ya site n'ikike ya iweghachite ọnọdụ mgbochi na-adịghị mma (ọnọdụ pathological) na ọnọdụ nguzozi na-adịghị mma nke dị nso (ọnọdụ physiological). Ọ naghị akwalite ma ọ bụ gbochie nzaghachi mgbochi ahụ n'otu akụkụ.

7.Ichịkwa oge ịhụ nsọ nwanyị

Naringenin nwere ọrụ yiri ọgwụ mgbochi mkpali na-abụghị steroidal. Ọ na-ebelata njikọ nke prostaglandin PGE2 site na igbochi cyclooxygenase COX, ma na-arụ ọrụ antipyretic, analgesic na mbufụt.

Dabere na mmetụta estrogen-dị ka naringenin, enwere ike iji naringenin maka ọgwụgwọ nnọchi estrogen n'ime ụmụ nwanyị postmenopausal iji zere mmeghachi omume ọjọọ siri ike kpatara site na iji estrogen ogologo oge.

8.Impact na oke ibu

Naringenin nwere mmetụta ọgwụgwọ doro anya na hyperlipidemia na oke ibu.

Naringenin nwere ike imeziwanye mkpokọta cholesterol dị elu na plasma ọbara, itinye uche TG (triglyceride) yana itinye uche na fatty acid efu na oke oke. Nnyocha na oke ụdị oke abụba achọpụtala na naringenin nwere ike ibelata ọkwa lipid ọbara site na-achịkwa monocyte peroxisome proliferator-activated receptor δ.

Site na nnwale ụlọọgwụ, a chọpụtara na ndị ọrịa nwere hypercholesterolemia na-ewere otu capsule nke nwere 400 mg nke naringin kwa ụbọchị maka izu asatọ. Mbelata nke TC na cholesterol lipoprotein dị obere na plasma belatara, ebe mkpokọta nke TG na cholesterol lipoprotein dị elu agbanwebeghị nke ukwuu.

Na nchịkọta. A kwadoro ikike Naringenin iji meziwanye hyperlipidemia na nyocha anụmanụ na ule ụlọ ọgwụ.

Ntuziaka ngwa

Naringin ntụ ntụ nwere mmetụta dịgasị iche iche nke ọgwụ ọgwụ na-eji ugbu a na ọgwụ na ngwaahịa nlekọta ahụike.

Naringenin

Naringenin soplaya

Yuantai Organic Bio na-agba mbọ inye ndị ahịa nnukwu ihe kacha mma Naringin ntụ ntụ na ọrụ ka onye ọ bụla na-azụ ahịa nwee ike ịnụ ụtọ nri eke, ahụike yana oke mma. Ọ bụrụ na ị nwere ajụjụ ọ bụla ma ọ bụ mkpa gbasara ngwaahịa anyị, biko nweere onwe gị ịkpọtụrụ anyị, anyị ga-azaghachi gị ozugbo enwere ike.

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