Hydroxytyrosol ntụ ntụ

Kedu ihe bụ hydroxytyrosol?

Hydroxytyrosol ntụ ntụ bụ ihe na-arụ ọrụ na oliv ma na-arụ ọrụ dị ka antioxidant na-arụ ọrụ nke ukwuu n'ime ahụ mmadụ. Antioxidants bụ ụmụ irighiri ihe na-eme bioactive a na-ahụ n'ọtụtụ osisi, mana ọrụ ha dịgasị iche. A na-ewere ya dị ka otu n'ime antioxidants kachasị ike, ọ na-achọsi ike. Ya oxygen free radical absorption ike bụ ihe dị ka 4,500,000μmolTE/100g: 10 ugboro nke green tii, na ihe karịrị ugboro 2 nke CoQ10 na quercetin.

Prọfesọ Liu Jiankang, onye isi Institute of Mitochondrial Biomedicine nke Xi'an Jiaotong University Academy of Sciences, jikọrọ aka na ụlọ ọrụ Switzerland DSM nutritional ngwaahịa ụlọ ọrụ na-eji usoro na-amụ ọrụ nke hydroxytyrosol, a polyphenol wepụ na mmanụ oliv, site n'ụzọ nke molekụla. bayoloji. , Nnyocha na-egosi na ihe a na-akwalite ọrụ mitochondrial site n'ịkwalite njikọ nke mitochondrial. 

Ha chọtara mmanụ olive ahụ hydroxytyrosol nwere ike ichekwa nke ọma mmebi oxidative na arụrụ ọrụ mitochondrial na sel retinal pigmenti epithelial nke acrolein kpatara, ihe na-egbu egbu nke sịga. , isi usoro ya bụ ime ka usoro enzyme abụọ na-eme ihe na-eme ka ọ ghara imebi ya na sel. Nsonaazụ ndị a na-egosi na ọ nwere ike inwe mmetụta nchebe na ịse anwụrụ na-akpata retina pigment epithelial cell degeneration, dị ka retinal maculopathy. Nsonaazụ na-akwadokwa na nri bara ụba na mmanụ oliv ga-aba uru na ọgwụgwọ nke ọrịa ndị metụtara mitochondrial dysfunction, dị ka ọrịa shuga na oke ibu.

Aha kemịkal bụ β-hydroxyethyl-dihydroxybenzene, nke bụ ngwakọta phenolic. Usoro ihe omimi ya bụ C8H10O3 na ịdị arọ ya bụ 154.1632. O nwere otu phenolic hydroxyl abụọ na otu hydroxyl mmanya na-egbu egbu. Ọ bụ molekul amphoteric nwere ma phenolic na mmanya hydroxyl. Ọ nwere mmetụta antioxidant siri ike ma nwee ike iwepụ nke ọma exogenous na endogenous oxides na free radicals site na ịchịkwa oxidation nke ọtụtụ acid fatty unsaturated.

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Na-emeso thrombosis, arteriosclerosis ma mezie lipids ọbara

Hydroxytyrosol dị ọcha nwere mgbochi mkpokọta mmetụta. Mgbe ịta ahụhụ bụ 100 mg / L, ọ na-ekere òkè na nhazi protein ma na-arụ ọrụ mgbochi nchịkọta. Ọ nwere ike igbochi ọrụ adhesion nke platelet, nke na-eme ka ọ dị irè na igbochi ịmepụta thrombus. Ihe kpatara hydroxytyrosol nwere ike ịlụso ọrịa obi ọgụ nwere njikọ chiri anya na mgbochi ya nke nchịkọta platelet. Ọ nwere ike igbochi njikọ nke thromboxane B ma na-abawanye mmepụta nke nitrous oxide, si otú ahụ nweta mmetụta anticoagulant. Hydroxytyrosol nwere ezigbo mgbochi thrombotic, atherosclerotic na lipid lipid na-achịkwa usoro ọgwụgwọ nke ọrịa obi ma nwee mmetụta ọgwụgwọ dị mma na ọrịa obi.

Mmetụta mgbochi-inflammatory

Mmetụta nke hydroxytyrosol na mkpụrụ ndụ THP-1 nke LPS na-ebute nke ọma na-ebelata ọnụ ọgụgụ nke mkpụrụ ndụ nwere NF-kB DNA-binding transcriptional, ma na-egbochi transcription nke tumor necrosis factor-α-inducible epoxy cyclooxygenase-2 (COX-2) na nitric oxide synthase (i-NOS) mkpụrụ ndụ ihe nketa na mgbochi nke COX-2 na iNOS bụ isi ihe na-egbochi mbufụt, na nyocha ọzọ na usoro mgbochi mkpali dị mkpa.

Mmetụta mgbochi pathogenic microorganism

Ọ nwere njirimara nke ụdịdị dị iche iche, yana ọrụ ya megide nje bacteria gram-positive dịkwa elu karịa nke nje bacteria Gram-negative. Ọrụ antibacterial abụghị naanị ike megide nje bacteria na-emerụ ahụ na eriri afọ, kamakwa megide lactobacilli thermophilic na bifidobacteria. Mmetụta dị na microorganisms pathogenic dị iche iche chọrọ ọmụmụ ihe ọzọ.

Mmetụta hypoglycemic

A na-achọpụta nke nta nke nta ma mụọ mmetụta hypoglycemic na usoro ya. Mmetụta hypoglycemic nke hydroxytyrosol nwere ike ime ka mfu nke ọrụ enzyme antioxidant, nke bụ isi ihe ngwọta maka hyperglycemia na bụ nnukwu nchọpụta.

Mgbochi na ọgwụgwọ nke ọrịa obi na cerebrovascular

Ọ nwere mmetụta doro anya na-ebelata ọbara-lipid. A na-ekwukwa na mmetụta hydroxytyrosol na mbelata cholesterol ọbara nwere ike ịbụ site na igbu oge na usoro oxidation lipid na ịba ụba ọrụ nke enzymes antioxidant, si otú ahụ belata ọkwa cholesterol serum, triglycerides na obere njupụta lipoprotein cholesterol.

Nnwale ndị metụtara ya na mmetụta mgbochi mkpali na mgbochi ịka nká nke hydroxytyrosol na dermal fibroblasts (HDFs)

Nnukwu hydroxytyrosol ntụ ntụ a na-ahụ ya na akwụkwọ oliv na mmanụ dị ka oleuropein. A kọwo mmetụta antioxidant na mgbochi mkpali nke hydroxytyrosol na ngalaba nri, ọgwụ, ọgwụ na sayensị ndụ. Otú ọ dị, a mụọbeghị ya n'ihe gbasara ihe ndị dị ndụ akpụkpọ anụ. Ndị nyocha ahụ gosipụtara nke a site na iji ụdị senescence cell UVA na-ebute na fibroblasts dermal mmadụ. Site na ọmụmụ ihe a, ndị nchọpụta na-egosi na hydroxytyrosol nwere mgbochi mkpali na mgbochi ịka nká na UVA-mebiri dermal fibroblasts mmadụ. Ndị na-eme nchọpụta kwenyere na hydroxytyrosol kwesịrị ekwesị ka e jiri ya mee ihe dị ka ihe ịchọ mma, nke nwere ike igbochi mkpali na-egbu oge ịka nká na fibroblasts mmadụ.

Ịka nká akpụkpọ ahụ bụ ihe ọhụrụ nke mkpụrụ ndụ na-enweghị ike ịmalite ma ọ bụ rụọ ọrụ nke ọma n'ihi mfu cell ma ọ bụ mmebi arụrụ arụ. Ịka nká nwere ọtụtụ ihe na-akpata ihe ndị dị ndụ, kemịkalụ, na anụ ahụ; A na-akpọ ịka nká akpụkpọ ahụ n'ihi na-aga n'ihu na-ekpughere radieshon ultraviolet dị ka fotoaging akpụkpọ. Ngosipụta akpụkpọ ahụ n'ọkwa dị elu nke ụzarị UV na-ebute cytotoxicity kpọmkwem na apoptosis na-esote. Mgbe ụzarị UV na-agbanye na fibroblasts ma ọ bụ anụ ahụ dị ndụ, okwu matrix metallopeptidase (MMP) na-abawanye na mmepụta collagen na-ebelata; nke a na-emecha mebie anụ ahụ njikọ dị na dermis. Mkpughe na-adịgide adịgide na UVA na-emetụta ụdị dị iche iche dị iche iche, ọ bụghị nanị na-emebi fibroblasts dermal ụmụ mmadụ kamakwa ọ na-emetụta ndụ cell na uto ma na-ebute protein denaturation, pigmentation, na mmepụta nke ụdị oxygen na-emeghachi omume. Tụkwasị na nke ahụ, ụfọdụ nchọpụta nyocha na-egosi na UVA na UVB nwere ike imebi DNA ma mepụta ụdị oxygen na-emeghachi omume, na-ebute apoptosis, nke na-ebute nzaghachi mkpali ozugbo ma ọ bụ na-apụtaghị ìhè. Ọ bụrụ na mmeghachi omume a na-etolite na akpụkpọ ahụ ruo ogologo oge, a ga-ezobe ihe ndị na-akpasu iwe gabiga ókè ma mebie anụ ahụ na mkpụrụ ndụ nkịtị, si otú ahụ ghọọ ihe na-akpata ọrịa ndị dị ka ọrịa cancer, ọbara mgbali elu, ọrịa shuga, na ọrịa obi. N'afọ ndị na-adịbeghị anya, ndị mmadụ na-arụsi ọrụ ike na-enyocha ihe ndị sitere n'okike na ọgwụ ọdịnala iji gwọọ ọrịa akpụkpọ anụ isi ike ma gbochie mmepe nke ọrịa anụ ahụ na-adịghị ala ala. A na-eji ihe ọmụmụ ndị a mee ihe dị ka ihe ntụaka maka mmepụta ihe ịchọ mma na ihe ndị na-edozi ahụ.

N’afọ ndị na-adịbeghị anya, a mụọla ma jiri mkpụrụ oliv mee ihe n’ọtụtụ ebe. Na mgbakwunye na mmetụta antioxidant ha, ha nwere ike ime ka usoro ahụ ji alụso ọrịa ọgụ sie ike ma nwekwuo ike. A na-akọ na ha na-arụ ọrụ nke ọma n'ịgwọ ọrịa iku ume na ọrịa anụ ahụ. Ọrịa ọnya na ahụ efe nke mgbaàmà oyi. A na-ewere akwụkwọ oliv dị ka ihe mgbagwoju anya polyphenol, yana nguzozi nke super polyphenols dị ka hydroxytyrosol, tyrosol, caffeic acid na oleuropein. A na-akọ DHPEA-EDA (hydroxytyrosol), nke a na-ahụkwa na mmanụ oliv, na-adị irè karị n'ichekwa mkpụrụ ndụ ọbara uhie site na mmebi oxidative karịa ihe ndị ọzọ. Ọmụmụ banyere mmetụta mkpali nke hydroxytyrosol na-atụle mmetụta anticancer ya na colon na ọrịa ara ara, mgbochi ya na neuroprotective mmetụta na osteoarthritis, na mmetụta mgbochi ya na nrụgide oxidative na ndị mgbasa ozi na-efe efe. Tụkwasị na nke ahụ, nchọpụta metụtara akpụkpọ ahụ nyochara mmetụta photoprotective na mgbochi melanogenic nke ogige phenolic dị na mpempe akwụkwọ olive na mkpụrụ ndụ HaCaT.

ngwa

Nnukwu hydroxytyrosol ntụ ntụ nwere mmetụta mgbochi mkpali, gbasaa arịa ọbara na mmetụta antibacterial, ma nwee ike igbochi atherosclerosis; N'ihi na hydroxytyrosol nwere ọrụ antioxidant siri ike, ọ nwere atụmanya ahụike dị ukwuu. Hydroxytyrosol bụ metabolite tyrosol nke a na-ahụkwa na mmanụ oliv nke nwere njirimara antioxidant siri ike.

A na-ejikwa Hydroxytyrosol mee ihe na ịchọ mma n'ihi mmetụta antioxidant dị ike ya

Hydroxytyrosol soplaya

Yuantai Organic Bio na-agba mbọ inye ndị ahịa ihe kacha mma hydroxytyrosol dị ọcha ntụ ntụ na ọrụ ka onye ọ bụla na-azụ ahịa nwee ike ịnụ ụtọ nri eke, ahụike yana oke mma. Ọ bụrụ na ị nwere ajụjụ ọ bụla ma ọ bụ mkpa gbasara ngwaahịa anyị, biko nweere onwe gị ịkpọtụrụ anyị, anyị ga-azaghachi gị ozugbo enwere ike.

Ngwugwu & Mbupu

Ụlọ ọrụ anyị na ụlọ ọrụ mmepụta ihe

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