Formononetin ntụ ntụ

Kedu ihe bụ formononetin?

Ngwakọta isoflavonoid Formononetin (FMN, 7-hydroxy-4′-methoxyisoflavone), nke a makwaara dị ka formononetin na formononetin, bụ nke a na-ahụ n'ọtụtụ ebe na astragalus, licorice, mgbọrọgwụ kudzu, na ọbara ọbara N'etiti osisi leguminous dị ka Trichophyton, ọ na-adị mfe soluble na methanol. , ethyl acetate, ether, na dilute alkali ngwọta, ma ọ siri ike igbari na mmiri. Nnyocha ọgwụ nke oge a na-egosi na formononetin nwere mgbochi tumor, hypolipidemic, anti-arrhythmic, antibacterial, antispasmodic, anti-lipid peroxidation, estrogen, wdg mmetụta, nwere ike imeziwanye ọnya atherosclerotic, ma nwee ike ikpochapụ oxygen. Free radicals, na-egbochi mgbasa nke vaskụla mkpụrụ ndụ anụ ahụ dị nro na ọrụ ndị ọzọ, a na-ejikarị ya eme ihe na-agwọ ọrịa ma nwee mmetụta ọgwụgwọ dị ịrịba ama.

Formononetin ntụ ntụ bụ phytoestrogen isoflavonoid, nke bụ isi ihe na-arụsi ọrụ ike nke osisi clover na-acha uhie uhie. Enwere ike wepụ ya ma mee ka ọ dị ọcha site na mmịpụta, ultrasound, microwave, supercritical, subcritical water, pressurization na ụzọ ọgwụ ndị ọzọ. A na-enweta usoro a site na osisi ndị sitere n'okike, a pụkwara ịmepụta ya ma wughachi ya site na ụzọ ndị na-emepụta ihe. Ọtụtụ nchọpụta egosila na formononetin nwere mmetụta mgbochi dị mma na ụbụrụ dị iche iche dị njọ dị ka ara, prostate, eriri afo, akpa ume, endometrium, ovary, wdg. Ya mere, ngwaahịa a sitere n'okike nwere uru nyocha dị mkpa n'ọhịa nke mgbochi ọrịa cancer na ọgwụgwọ. Formononetin bụ ụdị phytoestrogen bara ụba n'osisi uhie uhie na ọgwụ ọdịnala ndị China astragalus. Ọ nwere mmetụta ọgwụ ọgwụ dị ka ibelata ọbara mgbali elu, na-achịkwa nzaghachi mkpali na metabolism lipid.

Olee uru?

Mmetụta dị ka estrogen

Formononetin nwere mmetụta estrogen-dị ka n'ihi myirịta ya na diethylstilbestrol. Dị ka phytoestrogen, formononetin nwere ike ịhazi ọkwa hormone n'ime ahụ n'akụkụ abụọ ahụ, ya mere ọ na-arụ ọrụ nke ọma n'ịgwọ ọrịa nke ụkọ estrogen kpatara. Nnukwu doses nke formononetin nwere mmetụta estrogen-dị ka ahụ n'ime ahụ ma dịkwa mma maka usoro ọmụmụ.

Mmetụta nke formononetin na sistem obi na akwara obi

Nnyocha ọgwụ ọgbara ọhụrụ na-egosi na formononetin nwere ike ibelata ọkwa cholesterol, triglycerides, na lipoprotein-cholesterol dị obere n'ime ọbara, na-abawanye ọdịnaya nke lipoprotein-cholesterol dị elu, ma na-ahazi metabolism lipid ọbara n'ime ahụ.

Mmetụta anti-oxidize

Oxygen free radicals (ORF) bụ ihe sitere na ngwaahịa nke metabolism anụ ahụ ma nwee mmetụta oxidative siri ike, n'etiti nke OH nwere ihe ndị na-arụ ọrụ kemịkalụ. Ọ bụrụ na enweghị ike iwepụ oxygen free radicals na-emepụta n'ime ahụ mmadụ n'oge, ha ga-eme ka anụ ahụ na sel emebi na-adịghị agbanwe agbanwe. A kọwo na ọtụtụ mpụta ihe ọkụkụ nwere ọrụ antioxidant, dị ka polyphenols, alkaloids, na flavonoids. N'ime ọmụmụ ihe gara aga, a chọpụtara na formononetin nwere mmetụta mgbochi dị ịrịba ama na nhụsianya na radicals free radicals na hydroxyl radical · OH na in vitro mmeghachi omume usoro. Nnwale egosila na formononetin nwere ike ịkwalite ọrụ antioxidant enzymes superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) na catalase (CAT) na òké na ụdị vivo. Ọ nwekwara ike ibelata mmepụta oxygen free radicals. Ya mere, formononetin nwere ike ịkpata mmetụta mgbochi ọrịa kansa na vivo na in vitro site n'iwepụ radicals free oxygen na-emerụ ahụ na ịbawanye ikike antioxidant nke ahụ. Tụkwasị na nke ahụ, site n'echiche nke usoro ihe omimi na thermodynamics, e kpughere na saịtị na-arụ ọrụ nke formononetin na-arụ ọrụ antioxidant bụ mgbanaka B na usoro nhazi, na isi usoro bụ hydrogen atom transfer (HAT).

Na-ahazi mkpụrụ ndụ ihe nketa na okwu protein ma na-arụ ọrụ n'ụzọ ntụgharị mgbaàmà

Phytoestrogens nwere ike ịrụ ọrụ n'ọtụtụ ụzọ metabolic na ahụ mmadụ. Nnyocha e mere egosiwo na formononetin nwere ike igbochi protein usoro nchịkwa isi cell CyclinA, CyclinD1, CyclinE na PCNA site n'ịhazi okwu nke mkpụrụ ndụ ihe nketa na protein ndị metụtara ya, mee ka protein ndị metụtara apoptosis Bcl-2 ezinụlọ na ezinụlọ Caspase, na-egbochi matrix metals. Proteases (matrix metalloproteinases bụ ụdị nke endopeptidase nke na-adabere na zinc nke nwere ike imebi akụkụ dị iche iche na matrix extracellular nke na-egbochi ịkwaga cell ma na-enye ọnọdụ maka metastasis cell cancer) na ribosomal S6 protein kinase, nke na-egbochi mgbasa cell ozugbo ma ọ bụ na-apụtaghị ìhè, na-akwalite apoptosis cell. , na igbochi mbugharị tumor na metastasis.

Hazie ọrụ mgbochi ọrịa mmadụ ma melite gburugburu ebe obibi

Formononetin ntụ ntụ nwere mmetụta mgbochi na nlekọta ahụike dịka ichebe ahụ pụọ na mmebi, ibelata serum LDL cholesterol, meziwanye njupụta nke ọkpụkpụ, na-achịkwa secretion nke hormone, na n'ụzọ dị nro na-achịkwa gburugburu ime ahụ mmadụ na homeostasis, nke nwere ike ịdị mkpa maka ọrụ ya. Otu n'ime usoro. Dịka ọmụmaatụ, formononetin nwere ike igbochi okwu nke FOXA1 na GATA-3 nke ọma na mkpụrụ ndụ cancer endometrial na-adabere na estrogen, si otú a na-ebelata ọkwa nke ndị na-anabata estrogen, na-eme ka microenvironment endocrin dị n'ime ahụ dịkwuo mma, si otú ahụ na-eme ka prognosis dịkwuo mma. Na mgbakwunye, mmetụta mgbochi mkpali nke formononetin nwere ike inyere ahụ aka iwepụ ihe mkpofu nke metabolic, na-eme ka ahụ dị mma na gburugburu ebe obibi kwesịrị ekwesị maka metabolism cell nkịtị, ma welie ihe mgbochi ahụ na-egbochi mkpụrụ ndụ kansa.

Formononetin soplaya

Yuantai Organic Bio na-agba mbọ inye ndị ahịa ihe kacha mma nnukwu Formononetin ntụ ntụ na ọrụ ka onye ọ bụla na-azụ ahịa nwee ike ịnụ ụtọ nri eke, ahụike yana oke mma. Ọ bụrụ na ị nwere ajụjụ ọ bụla ma ọ bụ mkpa gbasara ngwaahịa anyị, biko nweere onwe gị ịkpọtụrụ anyị, anyị ga-azaghachi gị ozugbo enwere ike.

Ngwugwu & Mbupu

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