Ecdysterone ntụ ntụ

Kedu ihe bụ ecdysone?

Cyanotis arachnoidea CB Clarke, makwaara dị ka pearl dewweed, cockscomb ginseng, anemarrhena, wdg, bụ perennial procumbent herbaceous osisi nke genus Dewweed na ezinụlọ Commelinaceae. A na-ekesa ahịhịa na-acha anụnụ anụnụ ududo-silk na ndịda China, Taiwan, na Ndịda Ebe Ọwụwa Anyanwụ Eshia.

Osisi niile nke Cyanotis arachnoidea nwere tumadi ogige phytosterone, gụnyere 26 phytosterone components. β-ecdysterone, α-ecdysterone, turkesterone, na podosterone, n'ime nke β-ecdysterone nwere ọdịnaya kachasị elu.

Ecdysone ntụ ntụ bụ ụdị ihe nwere ọrụ molting siri ike, nke nwere ike ịkwalite uto cell. Ọ nwere ike kpalite nkewa nke mkpụrụ ndụ dermal ma mepụta epidermis ọhụrụ iji mee ka ụmụ ahụhụ na-agbaze. Ọ nwere ike ịkwalite njikọ protein n'ime ahụ mmadụ.

Achọpụtara ụdị ngwakọta a na ụmụ ahụhụ na mbụ, ma ịdị adị nke ecdysone bụ nke mbụ kọrọ na alaeze osisi na 1966. Mkpọrọgwụ na akwụkwọ nke ọtụtụ ferns na osisi ndị dị elu nwere ụdị ngwakọta a. Dịka ọmụmaatụ, a chọtara hydroxyecdysterone na achysterone na mgbọrọgwụ nke Achyranthes bidentata toro na Taiwan, na achyrososterone dịpụrụ adịpụ na mgbọrọgwụ nke Achyranthes bidentata.

Isi ihe nhazi nke ecdysone bụ na steroid core nwere njikọ abụọ nke ọnọdụ 7 na otu 6-keto, yana ọtụtụ hydroxyl dị iche iche, n'ihi ya, ọ nwere nnukwu solubility na mmiri.

Ọrụ nke ụdị homonụ a metụtara ụdị cis nke mgbanaka A / B, ya bụ, 5β-, n'ihi na 5a-epiecdysterone enweghị ọrụ homonụ metamorphic. Ecdysone abụghị naanị na-akwalite njikọ protein, kamakwa ọ nwere ihe omume dị ndụ dị ka iwepu cholesterol n'ahụ, iwetulata lipids ọbara, na igbochi mmụba nke shuga ọbara.

Ecdysone na-arụ ọrụ n'ahụ mmadụ iji kwalite njikọ protein, wepụ cholesterol n'ahụ, belata lipids ọbara, na-egbochi ịrị elu nke shuga ọbara na ihe omume physiological ndị ọzọ. A na-eji ya n'etiti ndị mmadụ maka ọrịa ogbu na nkwonkwo. Na sericulture, a na-eji ya ebelata afọ nke silkworms ma kwalite ịkpụ silk na ịkwa akwa; na aquaculture, a na-ejikwa ya n'ọtụtụ ebe n'ịzụ shrimps na crabs; na ihe ịchọ mma, a na-ejikwa ecdysone mee ihe dị ka mgbakwunye pụrụ iche; molting Hormones na-agbakwunyere na ihe ịchọ mma iji gbochie akpụkpọ anụ ahụ ma mee ka akpụkpọ ahụ dịkwuo nro. Ecdysone nwere ike imetụta usoro mmepe niile nke ụmụ ahụhụ site na larvae akpụpụtara ruo ndị okenye, yabụ ọ na-achịkwa ma ọ bụ na-egbu ụmụ ahụhụ ndị ọrụ ugbo. Emebela ya ma tinye ya dị ka ọgwụ pesticide nke ọgbọ nke atọ; ecdysone nwekwara mmetụta ụfọdụ na usoro physiological nke ihe ọkụkụ. , o nwekwara ezigbo mmepe na atụmanya ngwa na ihe enyemaka mkpụrụ osisi.

Olee uru?

1. Mmetụta ngwaahịa ahụike: obere lipids ọbara, belata shuga ọbara

Hydroxyecdysone nwere ike igbochi njikọ glucose imeju, yabụ na ọ nwere ọrụ hypoglycemic na-adabereghị na insulin. Enwere ike ime ka phosphorylation nke protein kinase (AKT) na hepatocytes.

2. Ngwa ngwaahịa ahụike: Kwalite njikọ protein

Ecdysterone na-emepụta protein site na ịba ụba amino acid. Usoro a dị ngwa ngwa, dị irè, ma nwee ike ịdịru ogologo oge. Ikike ya ịkpali mkpụrụ ndụ akwara iji mepụta protein dị oke mkpa.

3. Mmetụta ngwaahịa ahụike: mgbochi ike ọgwụgwụ, cholesterol dị ala

Na-eme ka ọnọdụ mkpụrụ ndụ mebiri emebi nke cortisol na-emetụta (ọkwa dị elu nke cortisol nwere ike ime ka shuga dị n'ọbara dịkwuo elu, agụụ na-abawanye, ụbara ibu, mbelata libido na oke ike ọgwụgwụ), na-emezi usoro nke njikọ ume (ATP na creatine), na-eme ka ọrụ imeju dịkwuo mma. ya mere ahụ nwere ike ime ngwa ngwa na mgbanwe na gburugburu ebe obibi na nrụgide. Enweghị mmekọrịta na homonụ n'oge usoro a.

Site n'ịkwalite ngbanwe nke cholesterol na bile acid, ecdysterone na-egosi ikike dị ka onye na-ebelata cholesterol. Nnyocha achọpụtala na mmetụta ya na-ebelata cholesterol bụ 2.5mg kwa kilogram nke arọ ahụ.

4. Mmetụta ịchọ mma: Kwalite nkewa cell na uto na oyi akwa dermal, rụzie akpụkpọ ahụ

Ihe a na-eji bụ ecdysterone dị ọcha (β-ecdysterone dị elu karịa 90% n'okpuru nchọpụta mmiri mmiri HPLC dị elu), nke bụ ntụ ntụ kristal dị ọcha. Ọ nwere otu mgwa ihe, ọ dịghị ndị ọzọ adịghị ọcha, ọ dịghị ihe nfụkasị mmeghachi omume anụ ahụ, nwere ike permeability, ike ngwa ngwa etinye obi gị dum site akpụkpọ na a mmiri mmiri steeti, na enhances cell metabolism na ọrụ.

Ọ nwere mma exfoliation, freckle mwepụ na-acha ọcha mmetụta, na-enwe ezi mmezi mmetụta na ihu chloasma, traumatic ọchịchịrị ntụpọ, freckles, melanin pigmentation, wdg O nwekwara doro anya mmetụta na otutu. Ụkpụrụ na-arụ ọrụ nke ecdysterone bụ ime ihe na akpụkpọ ahụ n'onwe ya, na-eme ka mkpụrụ ndụ kewaa ma na-eto eto, na-amụba collagen, na-ewepụ freckles, na-acha ọcha, na-edozi ụdị akpụkpọ ahụ site na anya miri emi. Ya mere, ọ dị iche na ngwaahịa ndị ọzọ na-agbakwunye collagen site n'èzí ma nwee ike nweta nkwalite dị mkpa. Mmetụta na ọnọdụ akpụkpọ ahụ.

5. Mmetụta ịzụlite ugbo:

Na ngwaahịa mmiri, ecdysone nwere ike ime ka shrimps na crabs wụfuo ha n'oge, wepụ nje ndị na-emerụ ahụ n'ahụ, si otú a na-eme ka uto dịkwuo elu; na-akwalite metabolism na protein njikọ n'ime ahụ, welie mgbochi nchekasị; na-emeziwanye nkwụsi ike nke oporo na nshịkọ, ma na-ezere ibe ha nke ọma, igbu ọchụ na-eme ka ọnụọgụ ndụ dị mma nke ukwuu; ngwaahịa ahụ nwere ihe ndị na-egbu egbu na nje bacteria, nke nwere ike imeziwanye ikike nke shrimps na crabs iji guzogide ọrịa.

Na sericulture, ecdysone nwere ike ime ka afọ silkworm dị mkpụmkpụ, mee ka ụyọkọ ahụ dị mma, ma kwalite ịkpụ silk na ịkwa akwa.

N'ihe gbasara ọgwụ pesticides, ecdysone nwere ike imetụta usoro mmepe niile nke ụmụ ahụhụ site na larvae apụta ruo na ndị okenye, yabụ ọ na-achịkwa ma ọ bụ na-egbu ụmụ ahụhụ ndị ọrụ ugbo. A na-emepụta ya ugbu a ma tinye ya dị ka ọgwụ pesticide nke ọgbọ nke atọ; Mmetụta nke ecdysone na usoro physiological nke ihe ọkụkụ Ọ nwekwara mmetụta ụfọdụ ma nwee ezigbo mmepe na atụmanya ngwa na ihe ọkụkụ mkpụrụ osisi.

6. Pharmacological mmetụta

Hydroxyecdysone na-eme ihe na ahụ mmadụ site n'ịkwalite njikọ nke collagen, mgbochi arrhythmia, na mgbochi ike ọgwụgwụ; na-akwalite uto cell, na-akpali nkewa cell dermal, na iwepu cholesterol n'ahụ; na-ebelata lipids ọbara, na-egbochi mmụba nke shuga ọbara; na-akpali akpali ịhụ nsọ, dehumidification, na analgesia, wdg Na-arụsi ọrụ ike; ọ bụ ihe e kere eke na-egbochi ọrịa cancer; kemgbe ọbịbịa dewgrass ecdysone na 1976, e mepụtala mbadamba mbadamba, injections, na ointments na-adịghị mma.

Ntuziaka ngwa

Ngwa ngwaahịa nlekọta ahụike

N'ihe gbasara ngwaahịa ahụike egwuregwu, ecdysone nwere ikike dị ukwuu iji kpalite njikọ protein na cytoplasm muscle site n'ịbawanye mgbakọ nke amino acid n'ime agbụ protein, na ikike a na-alaghachi na nsụgharị na usoro mbugharị nke uto protein. Ecdysone abụghị naanị uru ahụike mana ọ dịkwa mma. Ọ na-enyere aka mee ka mkpụrụ ndụ kwụsie ike n'oge mmebi cortisol, na-emezi usoro njikọ ike (ATP na sarcosine) ma na-eme ka ọrụ imeju dịkwuo mma ka organism wee nwee ike ime mgbanwe ngwa ngwa na mgbanwe gburugburu ebe obibi na nrụgide. .

Ngwa ọmụmụ

Nnukwu Ecdysone ntụ ntụ a na-eji na sericulture iji mee ka afọ silkworm dị mkpụmkpụ, dozie ụyọkọ ahụ, ma kwalite ntu na ịkwa akwa; ecdysone dị mkpa maka uto na mmepe, shelling na metamorphosis nke aquatic crustaceans - shrimps na crabs. Ihe bụ isi akụrụngwa nke "hormone shelling"; Ngwaahịa a dabara adaba maka ozuzu nke oporo, crabs na crustacean mmiri ndị ọzọ na ikpuru ala. Mgbe ha gbakwụnyechara ngwaahịa a, oporo na crabs nwere ike ịgbasa nke ọma ma kwalite igbutu shrimps na crabs. Nkwekọrịta nke shells ndị ahụ na-egbochi ndị mmadụ n'otu n'otu igbu onwe ha ma na-eme ka ọnụọgụ ndụ dị ndụ na nkọwapụta ngwaahịa dịkwuo mma.

Ngwa ịchọ mma

N'ihe ịchọ mma, a na-ejikarị ecdysone dị ọcha emeso ya, nke a na-akpọkwa "ecdysterone". Ọ bụ ntụ ntụ kristal dị ọcha ma ọ bụ kristal na-enweghị agba. O nwere otu ihe eji eme ihe, enweghi ihe nfụkasị ahụ na akpụkpọ ahụ, ma nwee ezigbo ihe onwunwe. Ọ nwere ike permeability na akpụkpọ ahụ nwere ike ịbanye ngwa ngwa na ọnọdụ mmiri mmiri; ọ bụ ihe dị irè nke nwere ike ịkwalite metabolism cell na ịgbalite, ma nwee ezigbo exfoliation, iwepụ ntụpọ na mmetụta na-acha ọcha. Ọ nwere ike na-agwọ chloasma ihu, traumatic ọchịchịrị ntụpọ, freckles, Ọ nwere ezigbo mmezi mmetụta na melanin pigmentation, wdg, na ọ nwekwara mmetụta dị ukwuu na otutu. Ọ dị elu karịa ngwaahịa ọ bụla dị ugbu a n'ahịa n'ịkwalite njikọ collagen.

Ecdysone nwere mmetụta dị mma na chloasma na-ada ada, pigmentation, ntụpọ ojii na-agbaji, na freckles na ihu, ma na-enwe mmetụta dị ukwuu na acne; ọ nwere ike ime ka ọnya akpụkpọ anụ nke ndị agadi gbawaa na ntụpọ na-apụ n'anya, na pityriasis dị mfe na-apụ n'anya, ihu wrinkles na-aghọwanye nke na-emighị emi, akpụkpọ ahụ nkịtị na-adịkwa mma karị. Ecdysone moisturizing na nke na-ekpo ọkụ bụ ihe mgbakwunye ịchọ mma nlekọta anụ ahụ sitere na osisi na-ekwe nkwa. Ọ bụ ihe dị irè nke nwere ike ịkwalite metabolism cell na ịgbalite, ma nwee ezigbo exfoliation, iwepụ ntụpọ na mmetụta na-acha ọcha. Ọ nwere ezigbo nrụzi mmetụta na ihu chloasma, traumatic ọchịchịrị tụrụ, freckles, melanin pigmentation, wdg O nwekwara doro anya mmetụta na otutu. Ecdysone dị elu dị ọcha nke a nụchara site na usoro pụrụ iche na-eji ihe ịchọ mma. Nkọwapụta ngwaahịa bụ HPLC 98% (chromatography mmiri mmiri dị elu), yana usoro ọgwụgwọ bụ: 0.1 ~ 0.35%. Na ụlọ ọrụ ịchọ mma, enwere ike iji ya na ude ihu, ihe dị mkpa, lotions, wdg.

N'ozuzu, ecdysone HPLC ≥ 60% (karịsịa 90, 95) na-eji maka nlekọta ahụike mmadụ, na-eme mbadamba nkume, capsules, wdg, na-enwe mmetụta nke ịba ụba protein muscle, nlekọta ahụike na-eme egwuregwu, wdg; ecdysone HPLC ≥ 50%, aquaculture; molting Hormone HPLC ≥98% kristal ntụ ntụ, nke a na-ejikarị eme ihe na ịchọ mma.

【Safety】

Ihe karịrị ọmụmụ 50 egosila na ecdysone enweghị mmetụta ọ bụla, enweghị mmekọrịta hormonal, yana oke nrịanrịa dị ala.

Na 1998, nyocha biochemical nke ICN nwalere ya, na data gosiri na ka ecdysone wee gosipụta nsi, ọ ga-erurịrị oke oke nke 6400mg/kg. Ọzọkwa, ọnweghị mmetụta ecdysone na sistemu homonụ mammalian ka akọpụtabeghị na nyocha endocrine nke homonụ uto na homonụ luteinizing.

Usoro a na-anabata nke ọma bụ 5 mg / kg kwa ụbọchị. Maka ndị mmadụ na-ata ahụhụ site na nrụgide na ike ọgwụgwụ n'ihi ngwa ngwa nke ndụ, usoro ecdysone akwadoro bụ 300-400mg kwa ụbọchị. Oke doses dị ka 400-600mg kwa ụbọchị dabara adaba maka mmega ahụ.

Hydroxyecdysone Supplier

Yuantai Organic Bio na-agba mbọ inye ndị ahịa ihe kacha mma nnukwu ecdysterone ntụ ntụ na ọrụ ka onye ọ bụla na-azụ ahịa nwee ike ịnụ ụtọ nri eke, ahụike yana oke mma. Ọ bụrụ na ị nwere ajụjụ ọ bụla ma ọ bụ mkpa gbasara ngwaahịa anyị, biko nweere onwe gị ịkpọtụrụ anyị, anyị ga-azaghachi gị ozugbo enwere ike.

Ngwugwu & Mbupu

Ụlọ ọrụ anyị na ụlọ ọrụ mmepụta ihe

mkpado na-ekpo ọkụ: Ecdysterone ntụ ntụ,Hydroxyecdysone, nnukwu ecdysterone ntụ ntụ, ndị na-ebubata, ndị na-emepụta ihe, ụlọ ọrụ, Zụrụ, ọnụahịa, maka ire ere, onye na-emepụta ihe, ihe nlele efu, OEM, ODM, akara nzuzo, akara ọcha.