Capsaicin nnukwu ntụ ntụ

CAS: 404-86-4
Usoro ihe omimi:C18H27NO3
Ibu ibu: 305.41200
Mmiri solubility: adịghị soluble
Ebe mgbaze: 62-65 Celsius (ọkụ)
Ebe esi mmiri: 511.5ºC na 760mmHg
Ọnọdụ nchekwa: Ngwaahịa a kwesịrị ka edochi ya ma kpuchie ya, chekwaa ya na nkụ
Asambodo:ISO9001,ISO22000,Kosher,Halal,HACCP
Mbupu ọsọ: 1-3 ụbọchị

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Gịnị bụ capsaicin ntụ ntụ?

YTBIO capsaicin, bụkwa nke a maara dị ka Capsaicin nnukwu ntụ ntụ, bụ ngwakọta organic nwere usoro ihe omimi C18H27NO3. N'okike, ọ dị na osisi Solanaceae Capsicum annuum na ụdị ya. Ọ na-esi na petroleum ether dị ka kristal monoclinic na mpempe akwụkwọ akụkụ anọ. Ntinye nke Ultraviolet dị na 227nm, 281nm (ε7000; 2500). Ọ bụ alkaloid vanillamide na-egbu egbu. 

Capsaicin nnukwu ntụ ntụ bụ ntụ ntụ kristal na-acha ọcha nke bụ ihe na-arụ ọrụ na-acha uhie uhie nke mkpụrụ ndụ Capsicum. Ebe mgbaze nke capsaicin bụ 64-68 Celsius C, ebe isi ya bụ 210-220 ° C (1.33Pa), ọ nwere nkwụsi ike kemịkalụ dị elu, na-agbaze ngwa ngwa na ihe mgbaze organic dị ka ethanol, ether, benzene, acetone, chloroform, wdg, dị ntakịrị soluble na carbon dioxide, ọ na-esikwa ike igbari Na mmiri oyi.

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Nkwadebe nke capsaicin

Enwere ụzọ atọ bụ isi maka ịkwadebe capsaicin: mmịpụta eke, biosynthesis na njikọ kemịkal.

(1) mmịpụta eke: N'oge mmalite nke mmịpụta capsaicin, a na-egwepịa ose chili mịrị amị na-acha uhie uhie ma were ihe mgbaze na-amịpụta. Mgbe itinye uche, enwetara mmiri mmiri na-acha uhie uhie na oroma-acha ọbara ọbara. A na-akpọ mmiri mmiri mmanu mmanu capsicum oleoresin. Nwere capsaicin, dihydrocapsaicin, dihydrocapsaicin na homodihydrocapsaicin, capsicum red pigmenti, carotene na tartaric acid, malic acid, citric acid na ihe ndị ọzọ. Mgbe a na-ewepụtakwa capsicum oleoresin na ether, itughari ethanol na alkaline aqueous solution, ma ọ bụ mmanụ ala ether, dichloroethane na ihe mgbaze ndị ọzọ, kristal capsaicin crude nwere ike nweta site na crystallization na petroleum ether ma ọ bụ n-ethane. Ka ọ dị ugbu a, usoro mmịpụta eke nke capsaicin gụnyere usoro ethanol, usoro acetone, usoro acid-base, usoro mmịpụta dị egwu, wdg.

(2) Biosynthesis: Enzymes amara ugbu a na-etinye aka na ụzọ njikọ capsaicin gụnyere phenylalanine lyase, cinnamic acid hydrolase, p-coumaric acid hydrolase, caffeic acid transmethoxylase na capsaicin synthase. Ihe mmalite phenolic na nhazi usoro capsaicin (p-coumaric acid, phenylalanine, caffeic acid, wdg) bụkwa ihe mmalite nke protein, alkaloids, flavonoids na lignin. Ya mere, biosynthesis nke capsaicin Enwere nsogbu nke asọmpi na ụzọ biosynthetic ndị ọzọ maka ndị na-ebute ụzọ, na enwere ike ịbawanye biosynthesis nke capsaicin site na nhazi usoro metabolic ma ọ bụ usoro mkpụrụ ndụ ihe nketa.

(3) Ngwakọta kemịkalụ: Site na nhazi kemịkalụ, capsaicin nwere ike were dị ka ihe amide nke sitere na fatty acids na vanillylamine mebere. Spath et al. eji isobutylzinc na 1,6-adipic acid monoethyl ester monoyl chloride mee ihe dị ka akụrụngwa. 8-Methyl-6-nonenoic acid nwetara site na njikọ kemịkalụ, bụ nke phthalate mere chlorinated wee meghachi omume na vanillylamine iji nweta capsaicin. Usoro a aghọwo usoro kpochapụwo maka njikọ capsaicin.

Ọrụ nke capsaicin

1.Analgesic mmetụta

Capsaicin nke a na-enye n'ime ma ọ bụ mpaghara nye ụmụ anụmanụ egosila na ọ na-enwe mmetụta dị ukwuu na mgbu nke mkpali ọkụ na-adịghị mma na mkpali kemịkal kpatara. Mgbe eriri irighiri akwara merụrụ ahụ, capsaicin na-ebu ụzọ mee ka ọ mara neurons na-emerụ ahụ ma kpata mgbu. Otú ọ dị, ntinye aka na-aga n'ihu ga-eduga na nkwụsị nke neurons nociceptive ma nwee mmetụta analgesic na mgbochi mkpali. N'oge na-adịbeghị anya, onye na-anabata capsaicin ejirila nke nta nke nta bụrụ onye isi n'ịmụ usoro mkpụrụ ndụ capsaicin na-achịkwa mgbu. Ọ bụ ụdị nnabata egosipụtara na njedebe njedebe nke irighiri akwara. Ọ bụkwa ọwa cation anaghị ahọpụta ligand-gated ma bụrụ nke ọwa ikike nnabata nke oge. ezinụlọ, dị ka obere diameter isi afferent neurons, nwere ike rụọ ọrụ site n'ọtụtụ akụkụ, dị ka protons, neuroreceptors na-akpata lipid na ndị mgbasa ozi mkpali iji rụọ ọrụ ozugbo ma ọ bụ dozie TRPV1. TRPV1-mediated Ca2 + flux na-eme ka ntọhapụ nke neuropeptides na neurotransmitters, ndị a na-ahụ maka mgbasa nke mgbu. N'oge na-adịbeghị anya, a kọwapụtara na capsaicin na-ejikọta na TPRV1 na njedebe na akpụkpọ anụ nke neurons nke mbụ, na-ahọrọ obere neurons sensọ ma na-amalite ụfọdụ mmeghachi omume cascade dị mgbagwoju anya, gụnyere imeghe ọwa ọrụ ndị na-anabata ihe na-agafe agafe na ikpochapụ P Substances, neuronal firing na ntọhapụ nke proinflammatory mediators, na desensitization nke ndị na-anabata ya.

2. Mmetụta nchebe nke obi

Nnyocha e mere egosiwo na capsaicin nwere mmetụta nchebe dị ukwuu nke obi. N'ihe karịrị afọ iri gara aga, enwere akụkọ gbasara mmetụta capsaicin na-egbochi nchịkọta platelet. Nnyocha e mere n'oge gara aga kwenyere na capsaicin na-egbochi nchịkọta platelet ọ bụghị site na platelet ndị na-anabata ya, kama site n'itinye n'ime sel sel nke platelet na ịgbanwe usoro nke akpụkpọ ahụ. Njirimara na/ma ọ bụ ntinye ion. Otú ọ dị, nnyocha ndị e mere n'oge na-adịbeghị anya achọpụtala na TRPV1 na-arụ ọrụ dị ka onye na-ahụ maka capsaicin na neurons sensọ na sel ndị ọzọ na-abụghị nke neuronal, ma dịkwa na platelet mmadụ. Capsaicin nwere ike ime ka mmụba nke Ca2 + na-agbapụta na Ca2 + ntọhapụ na sel platelet iji mee ka platelet rụọ ọrụ, na ihe a nwere ike igbochi TRPV1 antagonists 5-iodoresiniferatoxin na AMG9810, na TRPV1 egosikwara na ọ na-enye aka na ntinye ADP na thrombin. Ọrụ nke ịgbalite platelet.

3. Mgbochi cancer mmetụta

Site na mmụba na-aga n'ihu nke mmetụta ọgwụ ọgwụ nke capsaicin, mmetụta mgbochi ọrịa kansa ejirila nwayọọ nwayọọ dọta uche ndị mmadụ. Nnyocha e mere n'oge na-adịbeghị anya achọpụtala na capsaicin na-arụ ọrụ mgbochi ọrịa cancer site na igbochi mgbasawanye na ịkwaga mkpụrụ ndụ cancer na ịkpata apoptosis nke mkpụrụ ndụ cancer. Capsaicin nwere ike igbochi mgbasawanye ma mee ka apoptosis nke ọrịa cancer akpa ume, ọrịa cancer colorectal, ọrịa ara ara, mkpụrụ ndụ leukemia myeloid, wdg, ma nwee ike igbochi mbugharị nke mkpụrụ ndụ melanoma. Usoro molekul nke capsaicin na-egbochi kansa cancer bụ tumadi site na-emetụta mitochondria nke mkpụrụ ndụ kansa na ịkpata apoptosis. A na-eji mkpụrụ ndụ leukemia myeloid mmadụ mee ihe dị ka ihe nyocha ma chọpụta na capsaicin nwekwara ike imekọrịta protein inhibin 2 nke dị na akpụkpọ anụ mitochondrial dị n'ime. Protein proliferative 2 (PHB) na-ejikọta ma mee ka ọ nyefee ya na nucleus iji mezie okwu ederede nke ụfọdụ mkpụrụ ndụ ihe nketa dị ka RB, p53 na androgen receptor iji mezie apoptosis cell. PHB na-ejikọkarị ya na morphology nke mitochondria na apoptosis cell. Ya mere, usoro mgbochi ọrịa cancer nke capsaicin bụ ime ka apoptosis nke mkpụrụ ndụ kansa site na omume nke mitochondria na protein proliferation 2 iji mee ihe mgbochi ọrịa cancer.

4. Mmetụta na digestive usoro

Enwere ike iji Capsaicin were ọnụ mee ihe dị ka onye na-ahụ maka afọ, nke nwere ike ịkwalite agụụ ma melite mgbaze. Nnwale anụmanụ egosila na mmiri ose nwere ike ịkpali mucosa ọnụ ma mee ka mmegharị nke afọ sikwuo ike. Ngwakọta ọnụ ọnụ nke sitere na ose chili dị iche iche nwere ike ime ka mmiri na-amịpụta mmiri na ọrụ amylase. Otú ọ dị, nchịkwa ọnụ nke nnukwu doses nwere ike ime ka gastritis, enteritis, afọ ọsịsa, vomiting, wdg. E nwekwara akụkọ na capsaicin nwere ike ịbawanye mgbaze site n'ịbawanye ọrụ nke enzymes digestive. Capsaicin nwekwara ike ịbawanye nrịanrịa nke eriri afọ site na ijikọ na protein ndị na-anabata vanilloid 1 iji mezie nnabata nri nri.

Capsaicin nwere mmetụta nchebe na afọ. Microcirculation nke afọ na-arụ ọrụ dị mkpa n'ịkwado ihe mgbochi mucosal gastric na iguzosi ike n'ezi ihe nke mucosa. Iri irighiri akwara na mucosa gastric nwere ike ịhazi mgbasa ọbara. Capsaicin na-eweghachi ihe mgbochi mucosal gastric na mmebi mucosal site na ịkpali TRPV1 na neurons afferent nwere mmetụta iji hapụ diastolic peptide CGRP na nitric oxide, si otú ahụ na-abawanye nrịba ọbara n'etiti arịa ọbara na mucosa gastric.

5. Mgbochi itching mmetụta

Capsaicin nwere ike iguzogide itching akpụkpọ ahụ. Capsaicin na-arụ ọrụ nke ọma megide mkparị na-akpata histamine, itching nke mmiri na-ebute, ọzịza metụtara uremia, nodular prurigo na ọrịa mgbu na-emetụta ọrịa postoperative, na itching akpụkpọ anụ na-adịghị ala ala. Ọrịa, wdg niile nwere mmetụta ọgwụgwọ ụfọdụ. Ka ọ dị ugbu a, usoro mkpụrụ ndụ a kapịrị ọnụ nke capsaicin na-ebelata itching abụghị nke doro anya, mana ọtụtụ ndị nchọpụta kwenyere na ụkpụrụ ahụ nwere ike ịbụ na capsaicin na-akpali TRPV1 ma belata ihe P, si otú ahụ na-egbochi ihe P-eduzi na-akpalite itching. ụzọ mgbaàmà, si otú ahụ na-emepụta mmetụta nke iguzogide itching.

6. Antibacterial na ụmụ ahụhụ mmetụta

Capsaicin nwere mmetụta mgbochi dị ịrịba ama na Bacillus subtilis, Clostridium, Clostridium tetani, Bacillus cereus na Streptococcus pyogenes, mana ọ naghị arụ ọrụ megide Staphylococcus aureus na Escherichia coli.

7. Mmetụta neuroprotective

Enwere akụkọ ole na ole na capsaicin nwere mmetụta neuroprotective. Site n'ịmepụta ụdị Mongolian gerbil transient cerebral ischemia nlereanya, na-agwọ ụmụ oke nwere mkpokọta capsaicin dị iche iche, na iji electroencephalogram mkpokọta ike nchọpụta na ụzọ ndị ọzọ, a chọpụtara na capsaicin nwere mmetụta neuroprotective. Agbanyeghị, capsazepine na-egbochi ọrụ nke onye otu ezinụlọ vanilloid 1 (VR1), si otú a na-egbochi mmetụta neuroprotective nke capsaicin. Nke a na-egosi na mmetụta neuroprotective nke capsaicin nwere njikọ chiri anya na VR1, na usoro ya akọwapụtara chọrọ nyocha ọzọ.

8. Mmetụta antioxidant

Capsaicin nwere ike ichekwa mmepe nke nwa ebu n'afọ nke ethanol kpaliri site na antioxidant. Site na nleba anya morphological nke embrayo nke ụmụ oke ICR nke mmanya Z na-akpali, ma e jiri ya tụnyere ụmụ oke ICR na embrayo na-adịghị edozi ya na capsaicin na ethanol, enwere ike ịhụ na obere na nnukwu ụbụrụ ICR ụmụ oke nke ethanol kpalitere etoliteghị, ebe ndị nke ụmụ oke na-adịghị agwọ ọrịa etolitebeghị. Embrayo nke ụdị oke ICR na ụmụ oke ejiri capsaicin na ethanol gwọọ ya tolitere nke ọma. Onye edemede ahụ nwalere mmetụta capsaicin na ọrụ SOD wee chọpụta na ethanol nwere mmetụta mgbochi siri ike na ọrụ SOD, mana capsaicin nwere ike iweghachi ọrụ SOD, capsaicin nwekwara ike ịkwalite ngosipụta nke GPx gene, na nkwupụta ngwaahịa nke GPx gene nwere ike ịbawanye elu. ọkwa nke ọrụ SOD. Ọdịnaya nke oxides dị ka peroxide gas, ya mere capsaicin nwere ụfọdụ ikike antioxidant.

9. Mmetụta hepatoprotective

Capsaicin nwere ike ichekwa imeju ma kwalite ọrụ imeju site na iso ndị na-anabata TRPV1 na-emekọrịta ihe. Site n'ịmepụta ihe atụ nke ọdịda imeju na-agwụ agwụ nke sitere na nchịkwa ọnụ nke 200 mg/kg thioacetamide n'ime ụmụ oke anụ ọhịa, capsaicin na capsaicin receptor blockers ka awa 24 gachara. Ha bụ agonists na ndị na-emegide ndị na-anabata TRPV1 n'otu n'otu. Ọkwa 2-arachidonoylglycerol bụ ihe na-egosi ọrụ biochemical na histopathological nke imeju. Nnwale achọpụtala na capsaicin nwere ike melite ọdịda imeju nke thio-Zamide na-ebute, wee mee ka ọrụ na ọrịa imeju dịkwuo mma. Otú ọ dị, ndị na-egbochi capsaicin nwere ike igbochi mmetụta a nke capsaicin, nke na-egosi na mmetụta hepatoprotective nke capsaicin bụ site na onye na-anabata TRPV1, ma ọ dị mkpa ka a nọgide na-enyocha usoro mkpụrụ ndụ ya dị omimi.

Ngwa capsaicin na-arụ ọrụ

(1) Dị ka nri akụrụngwa

A na-eji ose chili eme ihe oriri, ma mgbe a na-eri ose chili ozugbo dị ka ihe nri nri, bioavailability nke capsaicin adịghị elu, ọ ga-anọgidekwa na-ahapụ ya na eriri afọ, na-akpasu mgbidi eriri afọ, na-akpata ahụ erughị ala afọ, na ọbụnadị. Ọkụ na-ere ọkụ, na-ebute hemorrhoid. Ịtinye capsaicin dị ka ihe eji eme nri nwere ike ịchịkwa ose nke ọma ma hụ na nnabata nke capsaicin dị mma.

(2) Dị ka akụrụngwa ọgwụ

Capsaicin nwere ịdị ọcha dị elu nwere mmetụta mgbochi mkpali na analgesic siri ike ma na-adịte aka. Iji ọnụ mee ihe nwere ike ịkwalite secretion ihe ọṅụṅụ gastric, ịbawanye agụụ, belata flatulence, melite ọrụ digestive ma kwalite mgbasa ọbara; ojiji n'èzí nwere ike ịgwọ eze mgbu, mgbu anụ ahụ, rheumatism, ọrịa anụ ahụ na ọrịa ndị ọzọ, ma nwee mmetụta dị ukwuu na ọgwụgwọ nke neuralgia. Iji ya mee ka mmanu mmanu nwere mmetụta dị ukwuu na neuralgia dị ka ọrịa ogbu na nkwonkwo na-adịghị ala ala, herpes zoster, bruises, wdg Ọ nwere mmetụta ọgwụgwọ dị mma na psoriasis na alopecia; jikọtara ya na morphine, ọ nwere ike ịgbatị oge analgesic ma belata ọnụ ahịa ya. Ariri ahụ.

(3) Dị ka akụrụngwa maka ngwaahịa nlekọta ahụike

Capsaicin nwere ike kpalie usoro thermogenic na ahụ ma mee ka metabolism dị ngwa. Capsaicin nwekwara ike ịkwalite mmepụta nke enzymes abụọ n'ime ahụ, belata mkpokọta abụba, ma na-ekere òkè na mbelata ibu.

(4) Dị ka chemical akụrụngwa

Ịgbakwunye capsaicin na mkpuchi na ihe mkpuchi nke wires na eriri nwere ike igbochi oke oke, oke bekee na anụmanụ ndị ọzọ iri eriri ahụ, ọ na-enwekwa mmetụta nke ịchụpụ amụ. Ịgbakwunye capsaicin na agba nwere ike ịchụpụ anwụnta nke ọma ma belata nrachi nke microorganisms. Ugbu a, a na-eji capsaicin eme ihe n'ọtụtụ ebe na agba mmiri. Ngwa ọzọ dị mkpa nke capsaicin dị ka isi akụrụngwa maka mmiri anya mmiri na ụlọ ọrụ ndị agha.

Dị ka ọnụ ọgụgụ si kwuo, ihe mejupụtara capsaicin bụ ihe dịka 60% n'ọhịa ọgwụ, 20% na mgbakwunye nri, 15% n'ọhịa pesticide na 5% na mpaghara ndị ọzọ. Mpaghara capsaicin bụ isi mba ụwa na-eri bụ United States, Western Europe, na Japan, bụ ndị zụlitere akụ na ụba na ọkwa ahụike. , South Korea, wdg, ihe a na-achọ capsaicin kwa afọ zuru ụwa ọnụ karịrị tọn 5,000, ebe mmepụta capsaicin kwa afọ nke ụwa bụ naanị ihe dị ka tọn 1,200, ma enwere nnukwu oghere n'ahịa. Site na mmepe ngwa ngwa nke ọgwụ, ụlọ ọrụ ọkụ, ụlọ ọrụ nri na ụlọ ọrụ ndị ọzọ, ọchịchọ nke mba ụwa na nke anụ ụlọ maka capsaicin ga-aga n'ihu na-eto eto, enwere atụmanya ahịa dị mma.

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Akụkọ nnwale YTBIO capsaicin

ITEM

STANDARD

TNsonaazụ EST

Nchọpụta

Ọ fọrọ nke nta ka ọ bụrụ kristal na-acha odo odo

Kwuru

Capsaicinoids

≥98%

99.14%

Capsaicin

≥95%

95.09%

Capsaicinoids ndị ọzọ

≤3%

2.14%

agbaze ebe

60-66 ℃

65 ℃

Loss na ihicha

≤1.0%

0.76%

arsenic

2PPM

Kwuru

Ngwá ígwè

5PPM

Kwuru

Ọkụ reisidue

≤1.0%

0.1%

Nnwale Microbiological

Ọnụ Ọgụgụ Ogugu

≤1,000cfu / g

79cfu / g

Akpụkpọ anụ na yist

≤100cfu / g

<10cfu/g

E.Coli

≤10cfu / g

<0.3cfu/g

Salmonella

-adịghị mma

-adịghị mma

Staphylococcus

-adịghị mma

-adịghị mma


Asambodo

YTBIO na-agba mbọ inye ndị ahịa ihe kacha mma Nnukwu capsaicin ntụ ntụ dị ọcha na ọrụ ka onye ọ bụla na-azụ ahịa nwee ike ịnụ ụtọ nri eke, ahụike yana oke mma. Ọ bụrụ na ị nwere ajụjụ ọ bụla ma ọ bụ mkpa gbasara ngwaahịa anyị, biko nweere onwe gị ịkpọtụrụ anyị, anyị ga-azaghachi gị ozugbo enwere ike.

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Ngwugwu & Mbupu

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Ụlọ ọrụ anyị na ụlọ ọrụ mmepụta ihe

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mkpado na-ekpo ọkụ:Capsaicin nnukwu ntụ ntụ, Capsaicin ntụ ntụ,Pure capsaicin ntụ ntụ, ndị na-ebubata, ndị na-emepụta ihe, ụlọ ọrụ, Zụrụ, ọnụahịa, maka ọrịre, onye na-emepụta ihe, ihe nlele efu, OEM, ODM, akara nzuzo, akara ọcha.


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