Baicalin ntụ ntụ

Nkọwa: 85%
Isi mmalite: mgbọrọgwụ Scutellaria baicalensis
Usoro nchọpụta: HPLC
CAS: 21967-41-9
Usoro ihe omimi: C21H18O11
Ibu ibu: 446.36
Mbupu ọsọ: 1-3 ụbọchị
Ngwaahịa: Ọ dị na ngwaahịa
Asambodo: HACCP, HALAL, KOSHER, ISO9001, ISO22000, FDA
MOQ: 25KG
Ngwugwu: 25kg / gbọmgbọm
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Kedu ihe bụ baicalin?

Baicalin ntụ ntụ bụ ngwakọta flavonoid ewepụtara na mgbọrọgwụ nke Scutellaria baicalensis. Ọ bụ ntụ ntụ edo edo dị ọkụ na ọnụ ụlọ ma nwee uto ilu. Na-adịghị ike na methanol, ethanol, acetone, dị ntakịrị soluble na chloroform na nitrobenzene, ọ fọrọ nke nta ka ọ ghara ịsacha na mmiri, soluble na acetic acid dị ọkụ. Ọ na-apụta akwụkwọ ndụ akwụkwọ ndụ mgbe ekpughere ya na ferric chloride, ma na-emepụta mpụta oroma mgbe ekpughere ya na ndu acetate. Mgbe agbazere na alkali na amonia, ọ na-apụta na mbụ edo edo, n'oge na-adịghịkwa anya na-atụgharị na agba aja aja. Ọ nwere ọrụ dị mkpa nke ndu ma nwee antibacterial, diuretic, mgbochi mkpali, cholesterol-ebelata, mgbochi thrombosis, enyemaka ụkwara ume ọkụ, na-ekpocha ọkụ na detoxification, hemostasis, mgbochi tocolysis, mgbochi-allergic na antispasmodic mmetụta. Ọ bụkwa onye so na mammalian imeju salvary enzyme A kpọmkwem ihe mgbochi nke nwere ike ịhazi ụfọdụ ọrịa. A na-ejikarị ya agwọ oke ọkụ, nkụchi obi na ọgbụgbọ n'oge okpomọkụ, oke ọkụ ọkụ, afọ ọsịsa na jaundice, ụkwara ọkụ ọkụ, oke ahụ ọkụ na polydipsia, vomiting-ekpo ọkụ, carbuncle na ọnyá, na dysphoria nke nwa ebu n'afọ. . Tụkwasị na nke ahụ, baicalin nwekwara ike ịmịkọrọ ụzarị ultraviolet, wepụ oxygen free radicals ma gbochie mmepụta nke melanin. Ọ bụ ezigbo ihe ịchọ mma akụrụngwa na-arụ ọrụ nke ọma.

Scutellaria baicalensis mgbọrọgwụ wepụ ntụ ntụ

Olee uru?

1. Mmetụta mgbochi ọrịa: Baicalin ntụ ntụ nwere nnukwu nje bacteria ma nwee mmetụta siri ike na Staphylococcus aureus na Pseudomonas aeruginosa. Sun Dongmei na ndị ọzọ agafeela ule nje bacteria na Staphylococcus aureus in vitro na-eguzogide ọgwụ na Staphylococcus aureus na-eguzogide ọgwụ na vivo. Mmetụta nchebe nke ọrịa staphylococcal na ụmụ oke ma hụ mmetụta antibacterial nke baicalin. Opekempe ihe mgbochi mgbochi nke baicalin na compound sulfamethoxazole (SMZ-TMP) megide Staphylococcus aureus na-eguzogide ọgwụ bụ 2 mg / ml na 0.45 mg / ml n'otu n'otu. Nnwale na vivo na-egosi na baicalin (100 mg/kg) nwere ike ibelata ọnụ ọgụgụ ụmụ oke na-anwụ na Staphylococcus aureus na-eguzogide ọgwụ na-egosi na baicalin nwere mmetụta antibacterial na Staphylococcus aureus na-eguzogide ọgwụ.

2. Mmetụta nchebe na mmerụ imeju: Jiri CCl4 na D-galactose mee òké nnukwu mmerụ ahụ imeju ihe nlereanya, wee jiri nyocha colorimetric tụọ ọrụ nke serum aspartate aminotransferase na alanine aminotransferase; tụọ serum Superoxide dismutase, ọrụ glutathione peroxidase na ọdịnaya malondialdehyde. Nsonaazụ Baicalin nwere ike belata mmụba nke serum aspartate aminotransferase (AST) na alanine aminotransferase (ALT) na ụmụ oke nwere nnukwu mmerụ ahụ imeju nke CCl4 na D-galactose kpatara; Ọrụ nke oxide dismutase (SOD) na glutathione peroxidase (GSH-Px) na-abawanye nke ukwuu, na ọdịnaya nke malondialdehyde (MDA) na-ebelata. Nsonaazụ gosiri na baicalin nwere mmetụta nchebe na nnukwu mmerụ ahụ imeju na ụmụ oke nke CCl4 na D-galactose kpatara. N'ime nnwale ahụ, SOD na GSH-Px n'ime otu nchịkwa dị elu nke ukwuu karịa ndị nọ n'otu ụdị ahụ, ebe ọdịnaya MDA dị ala nke ukwuu, na-egosi na usoro hepatoprotective nke baicalin nwere njikọ chiri anya na nguzogide ya na radical lipid peroxidation.

3. Mmelite nke ọrịa mamịrị nephropathy: Ọrịa mamịrị nephropathy (DN) bụ otu n'ime nsogbu microvascular na-ahụkarị nke ọrịa shuga mellitus (DM), nyocha banyere ọrịa ya na-abụkarị okwu na-ekpo ọkụ na ngalaba ọrịa shuga n'ụlọ na ná mba ọzọ. Hyperglycemia bụ ihe mmalite nke na-ebute ọrịa nephropathy na-arịa ọrịa shuga, na site n'usoro usoro n'ime ahụ, ọ nwere ike ịkpata nrụgide oxidative na mmeghachi omume mkpali n'ime ahụ, na-eduga na ịgbalite netwọk cytokine mpaghara na akụrụ na-eduga na DN. N'ime usoro ahụ dum, usoro renin-angiotensin na-arụ ọrụ dị mkpa, n'ime nke angiotensin II (Ang II) bụ ihe kachasị arụ ọrụ na usoro a ma nwee njikọ chiri anya na DN. Mgbe ọgwụgwọ baicalin gasịrị, a weghachiri AngII nke ukwuu, nke bụ ebumnuche nchekwa baicalin maka ọrụ gbasara akụrụ na oke DN. Ya bụ, baicalin na-agwọ ma ọ bụ na-echebe DN site na ibelata ọrụ nke sistemu renin-angiotensin (RAS) n'okpuru hyperglycemia. Ọrụ gbasara akụrụ na oke. Na mgbakwunye, baicalin nwekwara ike iweghachi ọrụ akụrụ site n'ibelata ọbara mgbali elu na nrụgide intraglomerular, meziwanye gburugburu ebe obibi ọbara na ọrụ ọbara mgbe ibelata AngII.

4. Mmezi na mmetụta nchebe na mmerụ ụbụrụ: Hu Xiumei jiri usoro suture guzobe ihe nleba anya nke mmerụ ahụ nke ụbụrụ ischemia-reperfusion kpatara nke etiti ụbụrụ ụbụrụ nke etiti na oke, wee hụ mmetụta nke baicalin na ọnụọgụ omume na ụbụrụ ụbụrụ na oke na ụbụrụ ischemia-reperfusion. ọnụego, ọdịnaya mmiri ụbụrụ, yana mmetụta nke anụ ahụ ụbụrụ NO, NOS, MDA, na SOD. Achọpụtara na baicalin nwere ike imeziwanye nsogbu omume nke ụbụrụ ischemia-reperfusion na oke na-akpata, na-ebelata ọnụ ọgụgụ infarction, belata ọdịnaya mmiri nke ụbụrụ ụbụrụ, ma belata ọdịnaya nke NO na ọrụ NOS na ụbụrụ ụbụrụ. si otú a ibelata mmetụta akwara ozi nke NO. Cytotoxicity. N'otu oge ahụ, baicalin nwere ike ibelata ọdịnaya nke MDA na ụbụrụ ụbụrụ nke ischemia-reperfusion oke ma na-abawanye ọrụ nke SOD, si otú ahụ na-egbochi peroxidation lipid nke free radicals na-ebelata mmebi nke free radicals na ụbụrụ ụbụrụ. Baicalin nwere mmetụta nchebe dị ukwuu na ụbụrụ ischemia-reperfusion mmerụ na oke, nke nwere ike jikọta ya na mmetụta antioxidant ya na mmalite nke ụbụrụ ischemia-reperfusion. N'otu oge ahụ, baicalin nwere mmetụta nchebe na nrụzi na nhụsianya mmụta na ọrụ ebe nchekwa na ụbụrụ ischemia-reperfusion ụdị oke.

5. Mmetụta na retinopathy: Song Haogang et al. guzobe ụdị anụmanụ nke edema na-egbu egbu na-egbu egbu, na-eji nyocha anya coherence tomography (OCT) na-aga n'ihu na-ahụ mgbanwe dị na ọkpụkpụ retinal edema na-egbuke egbuke, ma jiri ya tụnyere nsonaazụ nke nchọpụta morphology retinal na nha nha anya. N'iji ya tụnyere, a na-atụle mmetụta baicalin na-egbochi ọzịza na-egbu egbu nke retina site na imaging na histology, na-enyocha mmetụta nke mkpokọta ọgwụ dị iche iche. Baicalin nwere mmetụta inhibitory dị ịrịba ama na retina extracellular mkpali edema na ọ dịghịkwa irè karịa n'elu corticosteroids.

6. Mmeghachi omume nfụkasị ahụ: Nhazi mmeghachi omume nke baicalin bụ otu nke ọgwụ cromoglycate disodium na-eme ka ahụ ghara ịdị nro, yabụ mmetụta mgbochi nfụkasị ahụ nwekwara otu ihe ahụ.

Usoro ikike antioxidant

Baicalin bụ antioxidant dị irè nke nwere ike igbochi mmeghachi omume oxidation nke ikuku oxygen na-akpata dị ka anions superoxide na catalase. Isi usoro nke mmetụta antioxidant ya bụ:

① Ọdịdị na-ekpebi ọrụ. Nhazi kemịkal nke baicalin nwere otutu otu phenolic hydroxyl (lee foto 1). Ndị otu phenolic hydroxyl na-emeghachi omume na radicals n'efu iji mepụta radicals free semiquinone kwụsiri ike, si otú ahụ kwụsị mmeghachi omume nfụkasị radical free na igbochi mmeghachi omume okirikiri ọjọọ. mee;

② Baicalin nwere ike iwetulata okwu nke kelch-dị ka ECH metụtara protein 1 (Keap1) na ubiquitin linkase protein (cullin E3, cul3), mụbaa nkwupụta nke protein autophagy (protein 62, p62), ma mee ka Nrf2 antioxidant akara ngosi. ụzọ. Ọ na-emetụta ndetu nke ihe mmeghachi omume protein antioxidant ma na-ahazi superoxide dismutase (SOD), catalase (CAT), heme oxygenase 1 (HO-1), na glutathione (GSH) n'ime ahụ. na okwu nke NAD (P) H: quinone oxidoreductase 1 (NQO1) iji wepu oke free radicals na sel ma chebe mkpụrụ ndụ site na mmebi n'okpuru ọnọdụ hypoxia / reoxygenation Nzube. Na nkenke, baicalin nwere ike ọ bụghị naanị ịchụpụ radicals n'efu na usoro mmalite nke agbụ na mmeghachi omume antioxidant, kamakwa weghara radicals n'efu na agbụ mmeghachi omume free radical, gbochie mmeghachi omume radical n'efu, ma rụọ ọrụ okpukpu abụọ na mgbochi na agbụ. mkpa.

Baicalin

Usoro mgbochi ọrịa

Baicalin ntụ ntụ

Baicalin na-arụ ọrụ antimicrobial n'ọtụtụ akụkụ, gụnyere ịgbalite usoro ahụ ji alụso ọrịa ọgụ, igbochi ịmepụta biofilm, ibelata nzaghachi mkpali, na-ebibi usoro nke nje bacteria na-emerụ ahụ, na-egbochi nje bacteria, na-ebelata endotoxins nke nje bacteria, na ibelata nkwụsị nke ọgwụ.


Nnyocha e mere ugbu a na-egosi na baicalin nwere mmetụta mgbochi na nje gram-positive na gram-negative. Dịka ọmụmaatụ, na mastitis bovine nke E. coli kpatara, baicalin na-etinye aka na mgbidi E. coli cell, na-ebelata nkwụsi ike nke nje bacteria na ịba ụba nke mgbidi cell, n'ikpeazụ na-eduga na ọnwụ nje.

Ntuziaka ngwa

Baicalin ntụ ntụ bụ ngwakọta flavonoid ewepụtara ma kewapụrụ ya na mgbọrọgwụ Scutellaria baicalensis. Ọ nwere nnukwu ọrụ ndu ma nwee antibacterial, diuretic, mgbochi mkpali, mgbochi nfụkasị na mmetụta antispasmodic. Ọ ejirila ọnọdụ dị mkpa na ọgwụ ụlọ ọgwụ. Baicalin nwekwara ike ịmịkọrọ ụzarị ultraviolet, wepụ oxygen free radicals, ma gbochie mmepụta nke melanin. Ya mere, enwere ike iji ya na ọgwụ na ihe ịchọ mma. Ọ bụ ezigbo akụrụngwa maka ịchọ mma ịchọ mma na-arụ ọrụ.

Baicalin ntụ ntụ

Baicalin Supplier

Yuantai Organic Bio na-agba mbọ inye ndị ahịa ihe kacha mma nnukwu Baicalin ntụ ntụ na ọrụ ka onye ọ bụla na-azụ ahịa nwee ike ịnụ ụtọ nri eke, ahụike yana oke mma. Ọ bụrụ na ị nwere ajụjụ ọ bụla ma ọ bụ mkpa gbasara ngwaahịa anyị, biko nweere onwe gị ịkpọtụrụ anyị, anyị ga-azaghachi gị ozugbo enwere ike.

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