Aloin ntụ ntụ

Nkọwa: 16%-18%, 98%
Usoro nchọpụta: HPLC
Isi mmalite: Aloe Vera
CAS: 1415-73-2
Usoro molecular: C21H22O9
Onu ogugu oke: 418.39
EINECS: 215-808-0
Mbupu ọsọ: 1-3 ụbọchị
Ngwaahịa: Ọ dị na ngwaahịa
Asambodo: HACCP, HALAL, KOSHER, ISO9001, ISO22000, FDA
MOQ: 25KG
Ngwugwu: 25kg / gbọmgbọm
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Gịnị bụ aloin?

Aloin ntụ ntụ bụ ihe kemịkalụ ewepụtara na osisi aloe. Ọ bara ụba na nri ma nwee mmetụta ọgwụ bara ụba. A na-eji Aloe glycoside eme ihe n'ọtụtụ ebe na ọgwụ na mgbakwunye ahụike ma gosipụta na ọ nwere uru dị iche iche maka ahụike mmadụ. Isiokwu a ga-ewebata n'ụzọ zuru ezu aloin, ihe kemịkal nke a na-amịpụta n'osisi aloe, nke nwere ihe oriri na-edozi ahụ ma nwee mmetụta ọgwụ. A na-eji Aloin eme ihe n'ọtụtụ ebe na ọgwụ na ihe ndị na-edozi ahụ ma gosi na ọ nwere uru dị iche iche maka ahụike mmadụ.

Aloe glycoside bụ ihe sitere n'okike nke nwere aha bekee Aloin ma ọ bụ Barbaloin na usoro mkpụrụ ndụ ya bụ C21H22O9. Ọ na-atụgharị n'ime kristal agịga odo na ethanol. Na-agbaze ngwa ngwa na mmiri, pyridine, glacial acetic acid, formic acid, acetone, methyl acetate na ethanol. Ọ bụ ihe ọṅụṅụ a na-etinye na nke mịrị amị nke epupụta nke osisi Liliaceae monocotyledonous Aloe barbadensis Miller, Aloe ferox Miller ma ọ bụ osisi ndị ọzọ nwere njikọ chiri anya nke otu ụdị (dị ka Aloe vera). Ọ nwere mmetụta physiological dị ka purgative mmetụta, depigmentation mmetụta, tyrosinase inhibition, free radical scavenging mmetụta na antibacterial ọrụ. Nnyocha toxicology na nyocha vitro nwere ike ime ka mkpụrụ ndụ ihe nketa na nje bacteria na mkpụrụ ndụ anụ ahụ. Akụkụ nke kpatara esemokwu n'ihe gbasara nchekwa nri bụ anthraquinone laxatives nke aloe glycoside nọchiri anya ya. Ntụle nri ahụike ndị China chọrọ ka ọnụọgụ ngwaahịa aloe glycoside akwadoro kwa ụbọchị ekwesịghị gafere 2g. Enwere ike ịchekwa Aloe glycoside na ebe kwụsiri ike: okpomọkụ 15 ° C, nchebe pụọ na ìhè (ọnọdụ siri ike) na gburugburu acidic na pH = 1 (ọnọdụ mmiri mmiri).

Aloin ntụ ntụ

Chemical Njirimara

Ọ dị mfe soluble na pyridine, glacial acetic acid, formic acid, acetone, methyl acetate, ethanol, wdg. Nke sitere na osisi dicotyledonous Liliaceae osisi, Aloe vera Aloevera L, Aloe vera Aloeferox Mill, na Aloe vera wepụ. Aloin bụ ihe sitere n'okike dị n'ime osisi aloe dị iche iche. A na-eji Aloe glycoside mee ihe na mbụ dị ka ihe na-egbu egbu iji gwọọ afọ ntachi. Nnyocha e mere n'oge na-adịbeghị anya egosila na aloin na-eme ka mmepụta melanin na ọrụ transglutaminase dịkwuo elu.

Olee uru?

1. Mmetụta mgbochi mkpali

Ọ nwere mmetụta mgbochi mkpali doro anya ma nwee ike igbochi ọrụ nke mkpụrụ ndụ na-egbuke egbuke na ntọhapụ nke ndị mgbasa ozi na-egbuke egbuke. Nnyocha egosiwo na aloe glycoside nwere ike belata nchikota na ịgbalite leukocytes, na-egbochi njikọ nke ndị mgbasa ozi mkpali, ma na-achịkwa ụzọ mgbaàmà nke nzaghachi mkpali. Ya mere, a pụrụ iji aloin agwọ ọrịa dị iche iche na-akpasu iwe, dị ka ọrịa ogbu na nkwonkwo, enteritis, ịba, na otutu.

2. Antibacterial mmetụta

Aloin ntụ ntụ nwere mmetụta mgbochi na igbu egbu na nje bacteria na fungi dị iche iche. Nnyocha e mere egosiwo na aloe glycoside nwere ike igbochi uto nje site n'ibibi mgbidi cell nke nje bacteria, na-etinye aka na metabolism nke nje bacteria na igbochi uto nje. N'otu oge ahụ, aloe glycoside nwekwara ike ime ka ahụ ahụ nwee ihe mgbochi ọrịa nje na-egbu egbu ma mee ka ahụ ahụ na-eguzogide ọnwụ nke ọrịa nje na-akpata. Ya mere, enwere ike iji aloin agwọ ọrịa nje na fungal dị iche iche.

3. Chebe imeju

Aloe glycoside na-echebe imeju site na mmebi kemịkalụ na ọgwụ. Nnyocha e mere egosiwo na aloe glycoside nwere ike ibelata ọnọdụ nrụgide oxidative nke imeju, na-egbochi imeju fibrosis na bile synthesis, kwalite mmeghari nke mkpụrụ ndụ imeju, ma melite ọrụ imeju. Ya mere, enwere ike iji aloe glycoside na-agwọ ọrịa imeju dị ka ịba ọcha n'anya, cirrhosis na fibrosis imeju.

4. Mmetụta antioxidant

O nwere mmetụta antioxidant doro anya, nwere ike wepu radicals free n'ime ahụ ma belata mmebi nrụgide oxidative. Nnyocha e mere egosiwo na aloe glycoside nwere ike ịbawanye ọrụ enzyme antioxidant nke ahụ, kwalite usoro nchebe antioxidant, gbochie ọgbọ nke radicals free oxygen, ma belata mkpokọta ngwaahịa peroxidation lipid. Ya mere, a pụrụ iji aloe glycoside iji gbochie na ịgwọ ọrịa ndị metụtara nrụgide oxidative, dị ka ọrịa obi, ọrịa cancer, na ọrịa Alzheimer.

5. Mbelata shuga ọbara na lipids ọbara

Ọ nwere ike belata shuga ọbara na lipids ọbara, ma nwee mmetụta ọgwụgwọ ụfọdụ na ndị ọrịa nwere ọrịa shuga na hyperlipidemia. Nnyocha na-egosi na aloe glycoside nwere ike ịkwalite mmepụta insulin, kwalite mmetụta insulin nke glucose, ma belata ọkwa shuga dị n'ọbara. N'otu oge ahụ, aloe glycoside nwekwara ike igbochi njikọ abụba na nnabata cholesterol, ma belata ọkwa lipid ọbara. Ya mere, enwere ike iji aloe glycoside na-agwọ ọrịa metabolic dị ka ọrịa shuga na hyperlipidemia.


Na nchịkọta, aloe glycoside nwere mmetụta dị iche iche na mmetụta dị iche iche, gụnyere mgbochi mkpali, antibacterial, imeju nchebe, antioxidant, hypoglycemic na hypolipidemia, wdg Ya mere, aloe glycoside nwere nnukwu ngwa ngwa atụmanya na bụ nke ukwuu uru na ubi nke nkà mmụta ọgwụ na ọgwụ. ngwaahịa nlekọta ahụike. Otú ọ dị, ekwesịrị ịmara na ebe ọ bụ na ọnọdụ anụ ahụ na mkpa onye ọ bụla dị iche, mgbe ị na-eji aloe vera glycoside, ị ga-agakwuru dọkịta ma ọ bụ ọkachamara maka ndụmọdụ dabere na ọnọdụ ahụ akọwapụtara, ma jiri ya mee ihe n'ụzọ ziri ezi.

Ọmụmụ in vitro

Aloin, anthracycline eke ekepụtara na aloe vera, bụ ihe mgbochi tyrosinase nwere ọnụego mgbochi nke 2mM. Aloin na-egosipụta mmetụta mgbochi proliferative dị ịrịba ama na mkpokọta physiological (IC50 = 97μM), na-eme ka njide okirikiri cell n'oge S na ịba ụba nke HeLaS3 cell apoptosis (ruo 24%). N'ime ahịrị sel MCF-7, Aloin mere ka mbelata nke mkpụrụ ndụ n'ime oge mitotic site n'ịkwalite apoptosis, gbochie okwu nke protein topo IIa, ma mekwaa okwu nke protein B1 cell okirikiri.

Nsonazụ na mkparịta ụka

Nsi nke aloin na sel HepG2

Achọpụtara mmetụta aloin nwere na ndụ cell site na MTT. Nsonaazụ gosiri na mkpokọta aloin ruru 500 μg/mL emebighị iguzosi ike n'ezi ihe cell, ebe mkpokọta n'elu 750 μg/mL belatara ike ndụ cell (Njirimara 1a).

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Ọgụgụ 1 Cell viability (a); Mmetụta aloin na oriri glucose na sel HepG2 (b); Mmetụta nke aloin na ọrụ HK na PDH na sel HepG2 (c)


Mmetụta aloin na oriri glucose na sel IR-HepG2

Dịka egosiri na eserese 1 b, DEX gbochiri oriri glucose nke ukwuu, ebe ọgwụgwọ na 10-200 μg/mL nwere ike ịbawanye oriri glucose nke mkpụrụ ndụ IR-HepG2 n'ụzọ dabere na dose. Mmetụta nke aloin na IR na doses nke 100 na 200 μg / ml dị ka nke metformin na mkpokọta 1.5 μmol / L, na-egosi na aloin nwere mmetụta hypoglycemic.


Aloe glycoside na-abawanye ọrụ nke HK na PDH na sel IR-HepG2

HK na PDH bụ isi enzymes na-egbochi ọnụego glycolysis. Aloin na 50 na 100 μg/mL mụbara ọrụ HK na PDH (P <0.05, Figure 1c). HK na-abawanye ọdịnaya glycogen imeju yana itinye glucose maka mmepụta ume. Ọgwụgwọ nke T2DM na-esonyere mmụba nke ọrụ imeju pyruvate dehydrogenase siri ike. Ntinye nke PDH, enzyme mbụ nke pyruvate dehydrogenase complex, na-ebelata nguzogide insulin.


Mmetụta aloin na ibu ahụ yana ọkwa FBG na ụmụ oke T2D

A tụrụ mgbanwe na ịdị arọ ahụ na ụbọchị 0, 14 na 25 nke ọgwụgwọ (Fig 2a). Ibu ahụ nke ụmụ oke T2D na ụdị ụdị, metformin na otu aloe glycoside dị obere karịa nke ụmụ oke na otu nkịtị. Ụmụ oke ndị nwere ọrịa shuga tụfuru ibu ma e jiri ya tụnyere njikwa ndị na-abụghị ọrịa shuga. Ibu ahụ dị na otu ọgwụgwọ metformin belatara mgbe ụbọchị iri na anọ gasịrị, wee kwụsie ike. Na mgbakwunye, arọ ahụ nke ụmụ oke na-arịa ọrịa shuga na otu aloe glycoside belatara ntakịrị. Ọkwa FBG bụ ule a na-ejikarị achọpụta ọrịa shuga ma gosipụta insulin basal secretion na ọrụ beta-cell pancreatic. Ọgụgụ 14b na-egosi mmetụta ọgwụgwọ aloin na ọkwa FBG na ụmụ oke T2D n'ụbọchị dị iche iche. Nsonaazụ gosiri na ọkwa FBG nke oke oke ibu n'ime otu ụdị ahụ mụbara nke ukwuu, na-egosi na emebere ụdị òké ahụ nke ọma. Mgbe izu abụọ nke ọgwụgwọ gasịrị, ọkwa FBG na metformin na aloe glycoside ọgwụgwọ belatara ma e jiri ya tụnyere otu ụdị (P <2). Na mgbakwunye, ọkwa FBG na otu aloin ruru ihe fọrọ nke nta ka ọ bụrụ 0.05 mmol / L n'ụbọchị 11.1, nke yiri otu ọgwụgwọ metformin.

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Ọgụgụ 2 Na vivo mmetụta aloin na arọ ahụ (a), ọkwa FBG (b), AUC (c), ọkwa FINS na HbA1c (d), na EF index (e)


Mmetụta aloin na OGTT na ụmụ oke T2D

OGTT bụ ihe dị mkpa na-egosi oke ọrịa shuga. Mmetụta nke aloin na nnabata glucose na ụmụ oke T2D ka egosiri na eserese 2c. Nkwenye glucose nke ụmụ oke n'ime otu ụdị nwere nnukwu nsogbu, yana ọkwa glucose ọbara na 0 h dị elu nke ukwuu karịa nke ndị otu ndị ọzọ, ma mụbaa ngwa ngwa n'ime nkeji 30. AUC nke glucose na otu ụdị, metformin na otu ọgwụgwọ aloe glycoside bụ 53.37, 43.92 na 40.78 n'otu n'otu, nke dị ukwuu karịa 18.59 na otu nkịtị (P <0.01). Agbanyeghị, ma e jiri ya tụnyere ndị otu ụdị, AUC nke otu aloe glycoside ọgwụgwọ na otu metformin dị ala nke ukwuu (P <0.05). Nsonaazụ ndị a na-egosi na aloin nwere ike melite nnabata glucose na-adịghị mma na ụmụ oke T2D.


Mmetụta aloin na FINS na HbA1c na ụmụ oke T2D

Pasent nke haemoglobin glycated (HbA1c) hà nhata nhata nke mkpokọta HbA1c na mkpokọta hemoglobin (Hb) ma a na-eji ya enyocha nke ọma nke ọrịa shuga. Mgbe ịgba ọgwụ mgbochi STZ gasịrị, ọkwa FINS nke ụmụ oke ụdị T2D dị obere karịa nke ụmụ oke nkịtị (P <0.05). N'ime ụmụ oke T2D na-akpata STZ, ọkwa FINS mụbara nke ukwuu mgbe ọgwụgwọ aloin gasịrị (P <0.05), nke yiri mmetụta a na-ahụ na otu nkịtị (Fig 2d). Nsonaazụ ELISA gosiri na e jiri ya tụnyere otu nkịtị, ọkwa HbA1c n'ime otu ụdị ahụ mụbara nke ukwuu (P <0.01). N'ụzọ dị iche, ọkwa HbA1c hụrụ n'ime otu aloin a na-agwọ dị ala karịa ndị nọ n'otu ụdị. Ya mere, aloin nwere ike melite ọkwa shuga n'ọbara ruo n'ókè ụfọdụ.


Mmetụta nke aloin na ndepụta abụba epididymal na ụmụ oke T2D

A na-enyocha akara abụba epididymal (EF) na ọmụmụ ihe a (Fig 2e). Otu ihe atụ ahụ belatara, mana ọgwụgwọ metformin na aloe glycoside mụbara ya nke ọma. Nsonaazụ a na-egosi na aloin nwere ike ịkwalite ngbanwe nke glucose n'ime lipids ma gbochie nguzogide insulin.


Mmetụta aloin na histopathology imeju na ụmụ oke T2D

Dị ka e gosiri na Figure 3. Akụkụ anụ ahụ nke imeju site na ụmụ oke nkịtị gosipụtara usoro ihe omimi nkịtị na-enweghị mgbawa cell, nkesa edo, na hepatocytes na-adịghị mma (Fig 3a). Ndị otu ụdị ahụ nwere mgbasa nke etiti etiti, necrosis hepatocyte mpaghara, mkpokọta cell mkpali, mkpọchị, wdg (Nyocha 3b). Ọzọkwa, ntụpọ histopathological nke akụkụ anụ ahụ imeju sitere na ụmụ oke T2D dị omimi karịa nke sitere na ụmụ oke nkịtị. Ahụrụ mkpochapụ hepatocyte sara mbara na ụmụ oke na-enye nri HFSD, na-atụ aro ịba ụba nke abụba na anụ ahụ imeju. Agbanyeghị, ọgwụgwọ aloin na metformin mere ka mgbanwe akụkọ ihe mere eme na mbufụt nke ụmụ oke na-arịa ọrịa shuga dịkwuo mma, na-ebute usoro imeju dịtụ mma (Fig 3c, 3d).

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Ọgụgụ 3 Nyocha akụkọ ihe mere eme nke T2D mouse imeju (a) otu nkịtị, (b) otu ụdị, (c) otu metformin, (d) otu aloin.


Ọdịiche Alfa nke mkpụrụ ndụ ihe nketa 16srRNA

Iji chọpụta taxa pụrụ iche na taxa dị iche iche, ngalaba taxonomic na-arụ ọrụ (OTUs) na-agbakọta ma kewaa ya site na iji atụmatụ Venn, yana nchịkọta ruru 97% myirịta usoro. Achọpụtara ngụkọta nke 1 145 OTU na otu niile (Fig 4). Na mgbakwunye, a hụrụ 873, 922, 775, na 637 OTU n'ime otu ndị nkịtị, otu ụdị, otu metformin na aloe glycoside otu n'otu n'otu. N'ime ha, ndị nlereanya otu nwere kasị elu nke ukwuu nke intestinal flora na aloe glycoside otu nwere kasị ala. Na mgbakwunye, enwere ngụkọta nke 496 OTU n'ime otu òké 4, yana ngụkọta nke 105 OTU na otu ndị nkịtị, metformin na aloe glycoside na-agwọ. A na-ahụta 164 na 213 pụrụ iche OTU na otu nkịtị na ụdị ihe atụ, n'otu n'otu (Fig 4b), na-egosi ọdịiche dị na microbiota n'etiti ụmụ oke nkịtị na T2D. N'ụzọ dị iche, enwere naanị 35 na 15 OTU na otu metformin na aloin otu, n'otu n'otu (Fig 4a).

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Ọgụgụ 4 Venn eserese (a) nke nkesa OTU na nkịtị (acha anụnụ anụnụ), ụdị (green), metformin (red) na aloin (acha odo odo). Tulee OTU n'etiti otu nkịtị na ụdị ụdị (b), otu nkịtị na otu metformin (c), otu nkịtị na otu aloe glycoside (d), otu metformin na aloe glycoside (e)


Mmetụta aloin na osisi eriri afọ nke ụmụ oke T2D

Nsogbu metabolic dị ka ọrịa shuga na mgbanwe microbiota nke eriri afọ nwere njikọ chiri anya. Aloin na-enwe ike imegharị STZ-akpali akpali adịghị mma nke eriri afọ site na ibelata oke Firmicutes/Bacteroidates. N'otu oge ahụ, mgbe ọgwụgwọ aloin gasịrị, ụbara GCA-900066575, Lachnospiraceae_UCG-006, Firmicutes A2, Prevotellaceae UCG-001, Bacteroidetes na Bacteroidetes genera na-abawanye nke ukwuu.

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Ọgụgụ 5 Mmetụta nke aloin na microbiota intestinal na ụbara ìgwè dị iche iche nke ụmụ oke T2D na ọkwa phylum (a) na genus level (b); Mapụ nkesa obodo nke ụdị-ọkwa dị iche iche ụdị osisi evolushọn (c)


Mmetụta nke aloin na ụzọ akara JNK/IRS1/PI3K/AKT


Emere nnwale Western blot iji nyochaa mmetụta hypoglycemic nke aloe site na ụzọ akara JNK/IRS1/PI3K/AKT. Okwu nke protein JNK mụbara ngwa ngwa n'ime otu ụdị ahụ, si otú a na-ebute nguzogide insulin (Njirimara 6). E jiri ya tụnyere otu ihe nlereanya, otu aloe glycoside gbochiri okwu nke protein JNK nke ukwuu. N'otu oge ahụ, okwu protein IRS1/PI3K/AKT mụbara nke ukwuu mgbe a gwọchara ya aloin.

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Ọgụgụ 6 Mmetụta aloin na nkwupụta IRS1, PI3K, AKT na JNK na imeju.


Aloin soplaya

Yuantai Organic Bio na-agba mbọ inye ndị ahịa nnukwu ihe kacha mma Aloin ntụ ntụ na ọrụ ka onye ọ bụla na-azụ ahịa nwee ike ịnụ ụtọ nri eke, ahụike yana oke mma. Ọ bụrụ na ị nwere ajụjụ ọ bụla ma ọ bụ mkpa gbasara ngwaahịa anyị, biko nweere onwe gị ịkpọtụrụ anyị, anyị ga-azaghachi gị ozugbo enwere ike.

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Ngwugwu & Mbupu

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Ụlọ ọrụ anyị na ụlọ ọrụ mmepụta ihe

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