6 - gingerol

Aha ngwaahịa: Ginger wepụ ntụ ntụ
Aha Botanical: Zingiber officinale Rosc.
Akụkụ ejiri: Mgbọrọgwụ
Ihe na-arụ ọrụ: gingerols, 6-gingerol, 6-shogaol, 8-gingerol, 10-gingerol.
nkọwa:
Gingerols: 1% ~ 20% nke HPLC
Gingerol 1% soluble mmiri
Code CAS: 23513-14-6
Oke wepụta: 4: 1 ~ 20: 1
Ọdịdị: Yellow Brown Powder

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Kedu ihe bụ gingerol?

Gingerol bụ aha izugbe maka gingerol, shogaol, gingerone na ihe ndị ọzọ na-esi ísì ụtọ metụtara ginger. Ọ bụ isi ihe na-arụ ọrụ na ginger na ngwaahịa ndị a na-edozi. Ihe mejupụtara ya bụ 6-gingerol, 8-gingerol na 10-gingerol. , 6 - gingerol na gingerol na-adịkarị ma nwee nnukwu ọdịnaya. N'ime ha, 6-gingerol nwere ọdịnaya kachasị elu, na-aza ihe dịka 75% nke gingerols, na ọrụ ndụ ya dị elu. Gingerol nwere mmetụta ọgwụ dị iche iche dị ka antioxidant, ibelata mbufụt, na ịkwalite mgbochi.


Ginger bụ rhizome nke osisi ginger nke ezinụlọ Zingiberaceae. Ọ bụ ọgwụ ọdịnala na nri oriri. Ginger nwere ihe dị iche iche na-arụ ọrụ na-arụ ọrụ ma nwee ọrụ dị iche iche na-arụ ọrụ. Gingerol bụ otu n'ime ihe ndị na-arụ ọrụ nke ọma. Gingerol abụghị naanị isi ụtọ nke ginger ose, kamakwa isi ihe na-arụ ọrụ nke ginger ọtụtụ ọrụ. Ọ nwere atụmanya ngwa sara mbara na ngalaba ọgwụ, nri, condiments, ịchọ mma na ịdị ọcha.


Nnyocha na-egosi na 6-gingerol bụ ngwakọta nke ihe dị iche iche na-ekpebi ose na ụtọ ginger. Ọdịdị ya dị mgbagwoju anya mana ha niile nwere 3-methoxy-4-hydroxyphenyl na-arụ ọrụ dị iche iche, na agbụ hydrocarbon jikọtara na otu ọrụ ya dị iche iche. , nwere ike kewaa n'ụdị dị iche iche dị ka gingerols, gingerols, gingerones, gingerdiones na gingerdiol.


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Mwepụta nke gingerol ntụ ntụ

Ịmụ mmịpụta gingerol na ginger bara ezigbo uru maka ojiji ginger bara nnukwu uru yana mmepe ụlọ ọrụ ginger. Ụzọ mmịpụta nke a na-ejikarị maka gingerol na ginger gụnyere ịpị, mmịpụta ihe mgbaze organic, distillation molecular, enzymatic hydrolysis, usoro mmịpụta nke Ultrasonic, usoro mmịpụta na-enyere aka microwave, usoro mmịpụta CO2 dị egwu, wdg.


① Usoro ịpị. Ụzọ a na-achọsi ike bụ iji nweta ginger crude ozugbo site na ịpị igwe, wee jiri mmiri ozuzo na nkewa nweta obere gingerol. Ọrụ a dị mfe ma na-ewe obere oge, ma ọnụ ọgụgụ mmịpụta dị ala ma nwee ọtụtụ adịghị ọcha, nke chọrọ ka a dị ọcha na nkewa ọzọ.


② Usoro mmịpụta ihe mgbaze. Mwepụta ihe mgbaze na-adabere na ụkpụrụ nke miscibility yiri ya, na-atụle solubility nke gingerol, na-ahọrọ ihe mgbaze kwesịrị ekwesị, na igbari gingerol dị ka o kwere mee ka ị na-achịkwa ma na-ebelata mgbasa nke ihe ndị ọzọ. Ka ọ dị ugbu a, a na-ejikarị ihe mgbaze pola dị ka methanol, ethanol, butanol, na acetone. Agbanyeghị, n'ịtụle nchekwa nri nke gingerol, ihe mgbaze a na-eji bụ ethanol. Ka ọ dị ugbu a, enwere ọtụtụ ọmụmụ ụlọ gbasara mmịpụta ihe mgbaze nke gingerol na ginger. Ihe na-emetụta mmịpụta ihe mgbaze nke gingerol sitere na ginger bụ nke gụnyere ntinye ethanol, oke mmiri siri ike, ọnọdụ okpomọkụ, oge na oge mmịpụta. Mwepụta ihe mgbaze dị mfe iji rụọ ọrụ, nwere usoro dị mfe ma dị mma maka mmepụta mmepụta ihe. Otú ọ dị, ọ na-enwekwa nsogbu dị ka ogologo oge mmịpụta, nnukwu adịghị ọcha ngwaahịa, nnukwu mmịpụta okpomọkụ, nke na-emetụta ọrụ gingerol, na uru akụ na ụba na-adịghị mma, nke na-emetụta mmepụta na ngwa mmepụta ya.


③ Usoro mmịpụta nke Ultrasound na-enyere aka. Mwepụta nke ultrasonic na-enyere aka na-eji cavitation, n'ibu na thermal mmetụta nke ultrasonic ebili mmiri iji mebie usoro ginger cell nke ọma, na-akwalite mgbasa ngwa ngwa nke ihe ndị dị na gingerol, ma melite ọnụego mmịpụta nke gingerol. Mwepụta nke Ultrasound na-enyere aka belata oge mmịpụta, na-eri obere ume, ma belata okpomọkụ mmịpụta, nke bara uru iji chebe ọrụ gingerol ma nwee arụmọrụ mmịpụta dị elu. Ọ bụ ụzọ dị irè isi wepụ gingerol na ginger, mana ọ nwekwara mkpọtụ dị elu. Ọnụ ego dị elu.


④ Usoro mmịpụta na-enyere aka Microwave. Mwepụta nke Microwave na-enyere aka na-eji ọkụ ọkụ na-ahọrọ nke microwaves na-emepụta ngwa ngwa na okpomọkụ dị elu na nrụgide dị elu, na-eme ka mgbidi cell ginger gbawaa, na-ebelata nkwụsị nnyefe nke oke, na gingerol na-agbaze ngwa ngwa. Mwepụta nke gingerol nke Microwave na-enye aka na ginger nwere uru dị na nhọrọ dị mma, oge mmịpụta dị mkpirikpi, yana arụmọrụ dị elu. Otú ọ dị, ọnụahịa ngwá ọrụ mbụ nke usoro a dị oke elu na mmepụta mmepụta ihe adịghị eme. Ugbu a ọ bụ naanị nyocha ụlọ nyocha.

Gịnị bụ mmetụta nke gingerol?

01 Ngwá ọrụ dị ike maka ịbelata ibu na iweda abụba

Na-ebute mgbanwe nke adipocytes ọcha ka ọ bụrụ adipocytes aja aja

N'afọ 2017, otu nnyocha otu nyocha sitere na Mahadum California, San Francisco, nke e bipụtara na Nature Medicine, bụ obere akwụkwọ akụkọ nke akwụkwọ akụkọ mba ụwa kachasị elu Nature, kwuru na ọ bụghị nanị na a ga-eji ginger na-agwọ ọrịa typhoid na oyi. nwekwara ike inye aka gbochie oke ibu. Ime ka adipocytes ọcha ghọọ adipocytes agba aja aja bụ usoro ọgwụgwọ nwere ike ime. Nnwale achọpụtala na mgbe protein a na-akpọ SERCA2b na-arụ ọrụ n'ime mkpụrụ ndụ abụba ọcha nke ụmụ oke, mkpụrụ ndụ ga-emebi nnukwu glucose na acid fatty, na glycolysis nke ime ha na ọrụ iku ume nke mitochondrial aerobic ga-abawanye karịa 80%. Tinyere ọgbọ nke oke okpomọkụ. Ọbụna ihe ijuanya bụ na gingerol dị na gingerol nwere ike ịgbalite protein SERCA2b na sel beige. Chen Fang et al. chọpụtara na ọ na-emezi ọkwa ngosipụta nke akara ederede browning kpọmkwem Ucp1, prdm16 na pgc-1a site na ụzọ dabere AMPK, si otú ahụ belata okwu nke lipid metabolism transcription regulator C/ebpα na 3T3-L1 adipocytes dị iche. , nke na-eme ka proton na-agbapụta adipocytes ma na-akwalite iku ume mitochondrial, na-akwalite mgbanwe nke adipocytes ọcha ka ọ bụrụ adipocytes agba aja aja.


Na-egbochi njikọ nke fatty acid na adipocyte iche

Gingerol ntụ ntụ nwere ike iwetulata ọkwa nke serum triglyceride n'oge njikọ abụba abụba, meziwanye metabolism nke lipid na-adịghị mma n'ime ahụ, ma si otú a na-ekere òkè na mbelata ibu na iwetulata lipid. N'ime ụdị òké a na-eri nri dị elu, PPARγ na-arụ ọrụ site na SREBP-1c, na-ebute mbelata oxidation ọnụego nke fatty acids na-abawanye ọrụ FAS. Gingerol nwere ike ibelata okwu PPARγ na FAS site n'ịchịkwaa ihe ederede SREBP-1c ma gbochie njikọ nke fatty acids.


Choi et al. chọpụtara na itinye 6-gingerol na 3T3-L1 adipocytes nwere ike belata-achịkwa PPARγ, C/EBP, na protein protein regulatory regulatory element-bonding protein, fatty acid synthase, na fatty acyl-CoA synthase na triglyceride synthase usoro. na nkwupụta nke diacylglycerol acyltransferase, na-egbochi ọdịiche adipocyte. Na mgbakwunye, 6-gingerol na-egbochikwa adipocyte 3T3-L1 dị iche iche site na igbochi ụzọ protein kinase B na glycogen synthesis kinase 3β, si otú a na-arụ ọrụ mgbochi atherosclerotic.


02 Ngwa agha antioxidant

Gingerol nwere ike wepu hydroxyl free radicals na superoxide free radicals na ntule ma belata peroxides lipid na imeju na ụbụrụ ụbụrụ. Site n'echiche nke usoro ihe omimi, gingerols sitere na ginger nwere usoro phenolic, hydroxyl ma ọ bụ olefin ma bụrụ ezigbo ndị na-enye onyinye hydrogen ma ọ bụ electron. N'ihi resonance delocalization nke kpụrụ phenolic free radical intermediates na enweghị saịtị kwesịrị ekwesị maka oxygen ọgụ, ọhụrụ free radicals agaghị eme na-agaghị ngwa ngwa oxidized n'ihi na agbụ mmeghachi omume, n'ihi ya, ha nwere ike antioxidant ọrụ. .

Nnyocha achọpụtala na 6-gingerol nwere ike ịbawanye ọkwa nke ụdị oxygen reactive ROS na mkpụrụ ndụ cancer imeju mmadụ Hep G2 site na ibelata patulin PAT, na-ebelata mmepụta nke 8-hydroxydeoxyguanosine, na ịba ụba ọdịnaya glutathione. Mmetụta Antioxidant[28]. N'otu oge ahụ, mwepu crude nke gingerol na gingerol nwere ike ịbawanye ọrụ superoxide dismutase SOD na serum dịpụrụ adịpụ na imeju homogenate, na-ebelata malondialdehyde (MDA) lipid peroxide n'ime ọbara ahụ, ma melite ọrụ Antioxidant nke anụ ahụ.


03 Ngwá ọrụ nchebe imeju

Achọpụtara ya n'ụdị imeju mmadụ na òké na 6-gingerol nwere ike igbochi mkpokọta lipids na hepatocytes nke FFA fatty acid na-akpata, si otú a na-enweta mmetụta nchebe imeju. 6-Gingerol na-eme ka steatosis hepatic dịkwuo mma site n'ịbawanye ọrụ transcriptional nke hepatocyte nuclear factor HNF4a, na-eduga na mmụba na miR-467b-3p na mbelata glycerol-3-phosphate acyltransferase. N'ihi na mmepe nke NAFLD na ọrịa imeju na-adịghị egbu egbu nwere ike ịhazi site na microRNA, usoro a dị n'elu na-egosi ọrụ dị mkpa nke 6-gingerol-induced HNF4α/miR-467b-3p/GPAT1 cascade na-emezi NAFLD.

04 Ngwá agha mgbochi tumor


Gingerol bụ cytotoxic ma na-egbochi uto mkpụrụ ndụ kansa site n'ime ka apoptosis na mkpụrụ ndụ kansa. Ọ nwere mmetụta dị ukwuu n'igbochi ọrịa kansa ara, ọrịa kansa cervical na ọrịa cancer akpa ume. 6-Gingerol na-arụ ọrụ dị ka onye na-egbochi protein kinase ERK nke extracellular regulated ma ọ bụ c-Jun amino-terminal mitogen-activated protein kinase JNKMAP, site na iweda phorbol ester PMA-induced ERK phosphorylation, yana ịgbalite JNKMAP kinase na ihe ntụgharị protein activator. arụ ọrụ, si otú ahụ na-egbochi mgbasa nke mkpụrụ ndụ cancer.


10-gingerol, ihe ọzọ bụ isi nke gingerol, na-akwalite Hela cell apoptosis site n'ịchịkwa okwu nke mkpụrụ ndụ ihe nketa metụtara na ọtụtụ ụzọ mgbaàmà. 10-Gingerol na-egbochi usoro cell HeLa nke ọma na usoro G0/G1 tumadi site n'ịhazi mkpụrụ ndụ Cyclin D1. 10-Gingerol budata elu-na-achịkwa ngosipụta nke protein DR3 na DR5 na ụzọ akara ngosi ọnwụ na-anabata n'ime mkpụrụ ndụ Hela ma na-eme ka phosphorylation rụọ ọrụ nke protein Caspase; na-achịkwa okwu Bid, Bcl-2 na protein ọjọọ na ụzọ mgbama mitochondrial ma na-achịkwa Bax na cytochrome. Okwu nke C; na-ebelata nkwupụta nke PKCε na NF-kβ protein na ụzọ NF-kβ; na-egbochi phosphorylation nke protein PI3K nke ọma na ụzọ PI3K/AKT/AMPK/mTOR, ma na-akpalite phosphorylation nke ndị na-eme ihe mgbada ya AKT na P70S6K protein ion belatara, n'ikpeazụ na-ebute mbelata na mmụba na p-mTOR na p-AMPK okwu protein. , n'otu n'otu.

Ọ bụ ezie na ọtụtụ nnwale egosila na gingerol nwere mmetụta mgbochi tumor, usoro ya kpọmkwem ka kwesịrị inyochakwu ya.

Ngwa nke gingerol

1. Ngwa na nri

Ginger arụwo ọrụ dị mkpa na ndụ ndị mmadụ kemgbe oge ochie ma enwere ike iji ya mee nri, ntụ ntụ na ọgwụ. Nnyocha nke oge a na-egosi na gingerol nwere ezigbo antibacterial Njirimara na antioxidant Njirimara, na nwere sara mbara ngwa atụmanya nhazi nri.

Ịtinye gingerol na nhazi nke mpempe swiiti mango nwere ike ibelata mfu shuga na mmiri na mpekere mango. Ka emechara nkwalite ọtụtụ nzọụkwụ, ọ nwere ike ibelata mfu nke ogige bioactive eke dị na mango, meziwanye akara ọgụgụ isi ma belata ọdịiche agba. A na-emeziwanye ogo nri na ọrụ nke mbadamba swiiti mango nke ukwuu

Ịgbakwunye gingerol na nhazi nke mkpụrụ osisi na ihe ọṅụṅụ akwụkwọ nri nwere ike inye egwuregwu zuru oke na njirimara ya dị mma, meziwanye adịghị ike nke obere oge nchekwa mkpụrụ osisi na ihe ọṅụṅụ akwụkwọ nri, gbasaa ndụ ihe ọṅụṅụ, ma belata mgbakwunye nke ihe nchekwa artificial.

Na mgbakwunye, a na-etinye gingerol ahụ ewepụtara ozugbo n'ime nri ahụ ka ọ bụrụ ihe na-esi ísì ụtọ iji nye ya ụtọ. Ịtinye ya na azụ na ihe oriri ndị ọzọ nwere ike ịbawanye mmetụta mwepụ azụ azụ ma zere ịdị adị nke ginger particles nke na-emetụta uto mgbe ị na-eri nri. Ọ nwere ike belata oxidation lipid nke ọma, si otú a na-agbatị oge nchekwa nke fillet azụ.

Na ngwaahịa anụ a gwọrọ, ọ bụghị naanị na ọ ga-ewepụ nitrite dị n'ime ya, kamakwa iji nọgide na-egbuke egbuke nke anụ a kpụrụ akpụ. Ihe nkiri nke gingerol nwere ike igbochi oxidation nke abụba na anụ ezi jụrụ oyi ma gbasaa ndụ anụ ezi. A na-eji ihe mkpuchi plastik mee na gingerol iji chekwaa akwa. Ọ bụ akwụkwọ ndụ akwụkwọ ndụ na eke na ike ịgbatị oge nchekwa nke àkwá.


2. Ngwa na ọgwụ na nlekọta ahụike

A na-edekọ ginger na "Taiping Shenghui Prescription", "Shen Nong's Materia Medica" na "Ọgwụgwọ na ọrịa Febrile na dị iche iche". A na-ekesa ndenye nri nri n'ọtụtụ ebe ma nwee nnukwu mmetụta ọgwụ. Dị ka otu n'ime ihe ndị na-arụsi ọrụ ike na ginger, gingerol nwere mgbochi mkpali na ọrụ na-achịkwa lipid ọbara.

Site n'ịmepụta ụdị vomiting nke 2,2-azobis (2-methylpropylimida) dihydrochloride (AAPH) liposomes kpatara, gingerols na gingerol nwere ike imeziwanye mgbaàmà nke ọrịa tract digestive kpatara. Ọnụego mgbochi nke vomiting nwere ike iru 85%. Ọ nwekwara ike ibelata vomiting nke etuto ọjọọ na-akpata na ndị ọrịa chemotherapy ma nwee ike iji ya dị ka ọgwụ ọhụrụ na-egbochi emetic.

Na mgbochi na ọgwụgwọ nke polyfilariasis na azụ, gingerol nwere ike dochie ọgwụ. Mgbe ntinye nke 10-gingerol bụ 4 mg / L, ọ nwere ike ichebe azụ dị mma ka ọ ghara ibute nje nje ndị ọzọ. Ntinye nke 10-gingerol bụ 2 mg / L. 10-gingerol nwere ike ibelata ọnụ ọgụgụ ọrịa na nkezi ọrịa na-efe efe nke ahịhịa azu kaapu, ma melite ọnụego ndụ nke ahịhịa azu kaapu.


3. Ngwa na ịchọ mma

A na-ejikarị gingerol eme ihe ịchọ mma yana ihe ndị ọzọ dị na ginger. Na ncha ntutu, ịgbakwụnye ihe ọṅụṅụ ginger bara ụba na gingerol nwere ike wepu unyi n'isi ma gbochie uto nke nje bacteria. Ọ nwere ezigbo nkwụsi ike nke mgbọrọgwụ ntutu ma gbochie mmetụta ntutu isi.

Na ngwaahịa nlekọta anụ ahụ, gingerol ọ bụghị naanị na-arụ ọrụ mgbochi oxidative na akpụkpọ ahụ, kamakwa ọ nwekwara ike wepụ mmanụ n'ime anụ ahụ nke ọma ma gbochie uto nje, na-ebelata ọdịdị nke agwa mmanu mmanu. Ihe mkpuchi ihu nwere gingerol nwere ike ibelata mbufụt ma wepụ ihe otutu. na mmetụta na-eme ka ahụ dị jụụ.

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Asambodo

YTBIO na-agba mbọ inye ndị ahịa ihe kacha mma Dị ọcha 6-Gingerol nnukwu na ọrụ ka onye ọ bụla na-azụ ahịa nwee ike ịnụ ụtọ nri eke, ahụike yana oke mma. Ọ bụrụ na ị nwere ajụjụ ọ bụla ma ọ bụ mkpa gbasara ngwaahịa anyị, biko nweere onwe gị ịkpọtụrụ anyị, anyị ga-azaghachi gị ozugbo enwere ike.

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Ngwugwu & Mbupu

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Ụlọ ọrụ anyị na ụlọ ọrụ mmepụta ihe

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Mkpado na-ekpo ọkụ: 6-gingerol,Gingerol ntụ ntụ,Nnukwu 6-Gingerol dị ọcha, Ndị na-ebubata, ndị na-emepụta ihe, Ụlọ ọrụ, Zụrụ, ọnụahịa, maka ire ere, onye na-emepụta ihe, ihe nlele efu, OEM, ODM, labelụ nzuzo, akara ọcha.


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