1-Deoxynojirimycin ntụ ntụ

Isi mmalite: akwụkwọ mulberry
Nkọwa: 2%
Usoro nchọpụta: HPLC
Mbupu ọsọ: 1-3 ụbọchị
Ngwaahịa: Ọ dị na ngwaahịa
Asambodo: HACCP, HALAL, KOSHER, ISO9001, ISO22000, FDA
MOQ: 25KG
Ngwugwu: 25kg / gbọmgbọm
Ndị na-ere ahịa: ọ bụghị maka ndị ahịa ọ bụla

ZIPỤ NCHỌPỤTA
Budata site na ntaneetị
  • Nnyefe ngwa ngwa
  • Quality nkwa
  • 24/7 Ọrụ Ndị Ahịa
Product Okwu Mmalite

Kedu ihe bụ 1-deoxynojirimycin?

Akwukwo Mulberry weputara DNJ bụ alkaloid piperidine dịpụrụ adịpụ na mulberry osisi. Nnyocha e mere ugbu a achọpụtala na o nwere ihe omume physiological dị ka hypoglycemic, lipid-lowering, na antiviral. N'ihe gbasara metabolism lipid, nyocha ndị otu ahụ mere n'oge gara aga chọpụtara na usoro iwetulata egbugbere ọnụ nke DNJ bụ ọkachasị iji chịkwaa ọrụ enzymes metụtara metabolism lipid, na-egbochi njikọ nke fatty acid, ma kwalite fatty acid β-oxidation. Imeju na-arụ ọrụ dị mkpa na usoro nke lipid metabolism, na mitochondria bụ ebe dị mkpa maka fatty acid beta oxidation. Mahadum Southwest mụrụ mmetụta nke DNJ na mitochondrial biogenesis na autophagy na mkpụrụ ndụ imeju nke oke oke iji nyochaa usoro oke ibu ya wee nye ihe ndabere maka nyocha ọzọ miri emi na DNJ. Ọ na-enye ndabere maka mmetụta ya na mitochondria na oke oke na mmepe nke ngwaahịa ndị metụtara DNJ.

Akwukwo Mulberry weputara DNJ.webp

Olee uru?

Mmetụta hypoglycemic nke DNA

Akwukwo Mulberry weputara DNJ bụ ihe na-egbochi alfa-glucosidase n'ime anụ ahụ niile, nke na-ebelata hyperglycemia postprandial site na ibelata mgbaze carbohydrate na nnabata glucose. N'ihi ihe onwunwe a, enwere ike iji DNJ gwọọ ọrịa shuga na nsogbu ọrịa shuga, oke ibu na nsogbu ndị metụtara ya.

DNJ nwere mmetụta mgbochi dị iche iche na α-glucosidase na anụmanụ dị iche iche. DNJ na-egbochi sucrase na maltase na IC50. Mgbe mmetụta inhibitory nke DNJ na glycosidase ruru 50%, ntinye uche nke DNJ bụ 6.6 ~ 16 × 10-8M na 97.4 ~ 63 × 10-8M n'otu n'otu. DNJ na-egosipụta mgbochi asọmpi na α-glucosidase. Ọ na-emekarị n'akụkụ ma ọ bụ n'akụkụ ebe a na-ejikọta mkpụrụ ma na-asọmpi na mkpụrụ maka ijikọ na enzyme. Usoro hypoglycemic nke DNJ: A na-eme ka shuga dị na nri, dị ka starch, na-abanye n'ime afọ n'ihi ọrụ nke salivary alpha-amylase. Ihe dị ka pasent 70 nke akụkụ dị n'afọ nke na-ejikọtaghị ya na mmiri mmiri ka na-enweta hydrolysis. Mgbe ahụ, ọ na-abanye na duodenum ma na-aga n'ihu na-eme ka mmiri dị n'okpuru ọrụ nke ihe ọṅụṅụ pancreatic α-amylase iji mepụta disaccharides dị ka sucrose na maltose. Mgbe a na-ebuga disaccharide na eriri afọ, α-glycosidase na-agbanye ya n'elu akpụkpọ anụ microciliary dị n'elu nke obere eriri afọ n'ime monomers dị ka glucose na fructose, nke na-abanye n'ime ahụ site na mgbidi eriri afọ. , na-eme ka mmụba dị ukwuu na ntinye glucose n'ọbara. Mgbe ejikọtara nri ya na DNJ, nri ahụ na-erukwa obere eriri afọ wee ree ya na disaccharides. N'otu oge ahụ, DNJ na-abanyekwa n'ime obere eriri afọ ma jikọta α-glycosidase na ya. N'ihi na mmekọrịta nke DNJ na α-glycosidase dị ukwuu karịa nke disaccharides na α-glycosidase Ya mere, DNJ na-egbochi nchikota nke disaccharide na α-glycosidase. N'ihi ya, α-glycosidase enweghị ike imebi disaccharide, na disaccharide enweghị ike hydrolyzed n'ime glucose ma zigara ya ozugbo na eriri afọ. N'ihi ọrụ DNJ, obere glucose na-abanye n'ọbara, si otú a na-ebelata ọkwa shuga dị n'ọbara.


Mmetụta mgbochi nke DNJ na ọrụ nje

Nje virus immunodeficiency mmadụ (HIV) bụ retrovirus nke nwere ike ibute ọrịa lymphocyte T4+ (CD4+). HIV nwere protein envelopu glycosylated abụọ: glycoprotein gpl20 jikọtara ya na antigen CD4. Glycoprotein gp41 bụ protein transmembrane nke etinyere na envelopu nke akpụkpọ ahụ viral. gp120 na gp41 na-ejikọta na sel CD4+ wee banye n'ụdị akpụkpọ ahụ. Envelopu viral glycoproteins na ndị nnabata CD4 na-arụ ọrụ dị mkpa na ntinye viral, nhazi syncytial, na nje na-agbasa na sel ndị agbata obi. Ya mere, itinye aka na ọrụ nke envelopu glycoproteins nke viral ga-abụ ụzọ iji gbochie nje HIV na kemịkal. Nnwale mgbochi nke DNJ na Moloney murine leukemia virus (MoLV) na-egosi na DNJ nwere ọrụ antiretroviral dị ịrịba ama, yana IC50 nke 1.2 ruo 2.5 μg / ml, na ike mgbochi ya na-abawanye ka dose nke DNJ na-abawanye. N'oge a na-emepụta glycoproteins, usoro glycosylation dị ka mbufe nke polysaccharide precursors na peptides nascent na mgbanwe glucose na-esote dị mkpa maka nhazi na mpịachi nke envelopu HIV. Emechara ngbanwe glucose site na α-glucosidase I na II mkpochapụ nke mpụta α-1,2 glucose dị n'ime yana α-1,3 glucose residues. DNJ, dị ka onye na-egbochi enzymes ndị a, nwere ike igbochi mgbanwe nke glucose, ebe Gbanwee nje HIV na sel CD4 omenala. Tụkwasị na nke ahụ, nchịkọta nke glycoproteins na-eto eto na-akpata site na mmechi nke DNJ na glucosidase m nwere ike igbochi mmegharị nke viral site na igbochi njikọ cell, nje na-ejikọta ndị na-anabata sel, ntinye viral, na nhazi syncytium, si otú ahụ na-egbochi ọrụ Viral.

DNJ nwere nguzogide siri ike megide ụdị nje dị iche iche sitere na anụmanụ, dị ka nje ntị na-acha anụnụ anụnụ, nje ọrịa afọ ọsịsa na-efe efe, nje gastroenteritis na-ebufe porcine, nje avian bursal, nje ahụ ọkụ ezì Africa, wdg.

Ụkpụrụ nke hypoglycemic

1-Deoxynojirimycin ntụ ntụ na-edobe ọkwa shuga dị n'ọbara dị mma n'ahụ mmadụ site na njikọta nke ọtụtụ ụzọ. Nsonaazụ nyocha kemgbe ọtụtụ afọ egosila na usoro hypoglycemic nke DNJ dị mgbagwoju anya ma nwee ọtụtụ mmetụta ọgwụ na physiological.


Enwere ụzọ abụọ doro anya hypoglycemic nke DNJ:

1. Dị ka onye na-egbochi α-glucosidase, ọ na-egbu oge ịmịnye shuga na nri ma na-ebelata shuga ọbara postprandial. 2. Dị ka onye na-egbochi glycogen phosphorylase, na-egbochi ire glycogen imeju ma mee ka shuga dị n'ọbara guzosie ike.

2. Ọ nwere mmetụta ụfọdụ na ịkwalite nguzogide insulin.

Belata shuga ọbara postprandial: α-glucosidase na-ekesa nke ọma na obere eriri afọ mmadụ ma na-arụ ọrụ dị mkpa na mwepu nke carbohydrates. Ha na-ahụ maka ịkụda oligosaccharides dị ka disaccharides na nri n'ime shuga dị mfe dị ka glucose. Glucose a na-abanye n'ime ahụ site na mgbidi eriri afọ, na-eme ka mmụba dị elu nke shuga ọbara n'ime ahụ.


3. Ụzọ nke α-glucosidase imebi sucrose

1-Deoxynojirimycin ntụ ntụ bụ ihe okike na ike α-glucosidase inhibitor nke nwere ike ịsọ mpi na α-glucosidase na eriri afọ, yana njikọ ya siri ike karịa mmekọrịta nke disaccharides dị ka sucrose na maltose na α-glucosidase, na-ebelata oke α-glucosidase. Ihe puru omume nke ijikọ shuga na α-glucosidase na-egbochi ire ere nke disaccharides n'ime glucose, na nnukwu shuga anaghị etinye ya n'ahụ ma zigara ya na eriri afọ. N'ihi omume nke DNJ, obere glucose na-abanye n'ọbara, yabụ enwere ike idowe ọkwa shuga n'ọbara na ọkwa ahụike.


4 Usoro DNA ji eme ihe n'igbochi mmụba shuga ọbara postprandial

[Mee ka shuga dị n'ọbara guzosie ike] Enwere ike ree glycogen imeju ghọọ glucose n'okpuru ọrụ glycogen phosphorylase ma wepụta ya n'ọbara iji nye akwara na akụkụ ahụ ndị ọzọ, na-enye ike maka mmega ahụ. Site na ntughari nke glycogen imeju na glucose, shuga ọbara nke ndị nkịtị nọ na nguzozi siri ike.

Ọrụ imeju N'ime ndị ọrịa nwere ọrịa shuga, oke glycogen imeju na-agbaji banye glucose, nke na-eduga n'ọkwa shuga dị n'ọbara na-ebu ọnụ nke ukwuu. DNJ nwere ike ime ka shuga dị n'ọbara guzosie ike site na igbochi ọrụ nke glycogen phosphorylase, na-egbochi oke glycogen imeju ka ọ ghọọ glucose ma mee ka ọkwa shuga dị n'ọbara dịkwuo elu.


DNJ na-egbochi oke mmebi glycogen imeju

[Mmelite nguzogide insulin] Nguzogide insulin na-ezo aka n'ihe dị iche iche (gụnyere ihe mkpụrụ ndụ ihe nketa na oke ibu) na-eme ka insulin kwalite metabolism.


Ịrụ ọrụ nke oriri na ojiji na-ebelata, ahụ na-ezobekwa insulin dị ukwuu iji kwụọ ụgwọ. Nke a na-ebute hyperinsulinemia iji nọgide na-enwe nkwụsi ike nke shuga ọbara n'ime ahụ. Ọ bụrụ na ahụ mmadụ nọ n'ọnọdụ nke insulin na-eguzogide ogologo oge, ọ ga-abawanye ibu dị na pancreas, nke nwere ike ibute ọdịda nke ọrụ nzuzo nke insulin pancreatic, wee ghọọ ọrịa shuga.

DNJ nwere ike imeziwanye ihe mgbaàmà nke nguzogide insulin site n'ịnọgide na-enwe shuga ọbara dị mma, na-edozi metabolism lipid, na ịbawanye mmetụta insulin.


Ihe mgbaàmà a na-ahụkarị nke nguzogide insulin - oke ibu

DNJ bụ ngwaahịa ebumpụta ụwa sitere na akwụkwọ mulberry. Ọ bụghị artificially synthesized. Ọ dị mma na enweghị mmetụta ọ bụla. Enweghị mmetụta nke eriri afọ: DNJ enweghị ihe mgbaàmà nke ọgbụgbọ, ọgbụgbọ, afọ ntachi, mgbu afọ, afọ ọsịsa na ahụ erughị ala ndị ọzọ a na-ahụkarị na nkà mmụta ọgwụ ndị China. Adịghị emetụta ahụ ike imeju na akụrụ: DNJ adịghị mkpa ka imeju metabolized, na-anọ n'ime ahụ obere oge, ọ gaghị emebi ọrụ imeju na akụrụ mmadụ.

Mmetụta nke eriri afọ na-ebutekarị site na polyglycolysis fọdụrụnụ na eriri afọ. DNJ enweghị mmetụta mgbochi na α-amylase, ya mere, a gaghị enwe polysaccharides na-adịghị edozi nke fọdụrụ n'ime eriri afọ, na-ewepụ mmetụta dị njọ nke eriri afọ nke ngwaahịa acarbose kpatara.

Nnwale ọgwụ ọgwụ na-egosi na DNJ nwere obere oge obibi n'ime ahụ ma ọ nweghị nchịkọta nke nsị; ọ dịghị achọ metabolism imeju ma na-apụ apụ n'ụdị mbụ ya na-enweghị ihe ndị na-emepụta ihe.

Mulberry Leaf wepụ DNJ soplaya

Yuantai Organic Bio na-agba mbọ inye ndị ahịa nnukwu 1-Deoxynojirimycin ntụ ntụ na ọrụ kacha mma ka onye ọ bụla na-azụ ahịa nwee ike ịnụ ụtọ nri eke, ahụike yana oke mma. Ọ bụrụ na ị nwere ajụjụ ọ bụla ma ọ bụ mkpa gbasara ngwaahịa anyị, biko nweere onwe gị ịkpọtụrụ anyị, anyị ga-azaghachi gị ozugbo enwere ike.

Asambodo.jpg

Ngwugwu & Mbupu

ngwugwu.jpg

ngwa agha.jpg

Ụlọ ọrụ anyị na ụlọ ọrụ mmepụta ihe

ụlọ ọrụ.jpg

Send