Tranexamic Acid ntụ ntụ

Aha ngwaahịa: Tranexamic Acid ntụ ntụ
Code CAS: 1197-18-8
Ihe Nnwale: Ọkọlọtọ Nnwale
Ọdịdị: White Crystalline ntụ ntụ, enweghị isi
Nyocha: 99.0% ~ 101.0%
Solubility: Soluble n'efu na mmiri yana na glacial acetic acid, ihe fọrọ nke nta ka ọ bụrụ ihe a na-apụghị ịsacha na acetone na na ethanol (96%).
Ọnọdụ nchekwa: Ngwaahịa a kwesịrị ka edochi ya ma kpuchie ya, chekwaa ya na nkụ
Asambodo:ISO9001,ISO22000,Kosher,Halal,HACCP
Mbupu ọsọ: 1-3 ụbọchị

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Kedu ihe bụ Tranexamic Acid ntụ ntụ?

Tranexamic Acid ntụ ntụ n'ihi na akpụkpọ bụ ihe ịchọ mma akụrụngwa maka ịcha ọcha na freckle mwepụ, nke bụ sịntetik amino acid na a protease inhibitor, ọ nwere ike igbochi ọrụ nke tyrosinase enzymes na melanocytes, na-egbochi pigmenti nchịkọta. Ọ nwere ike ịgbaji ma kpochapụ mgbasa nke melanin n'ihi mkpughe UV, ma kwụsị bọọdụ ojii itowanye, gbasaa ma na-abawanye, si otú a gbochie ma ọ bụ melite pigmentation akpụkpọ.

 

E jiri ya tụnyere ihe ndị ọzọ na-acha ọcha, ọ nwere nkwụsi ike dị elu, acid na alkali na-eguzogide, na-emetụta ọnọdụ okpomọkụ na-adịghị ala ala, ọ dịghịkwa achọ nchebe ụgbọelu, ọ bụghị mmebi site na usoro mgbasa ozi, na-adịghị ewe iwe. Ya mere enwere ike ịchọta ya na ngwaahịa nlekọta anụ ahụ dị iche iche dị ka serums, creams, na masks.Ọ bụ White Crystalline Powder, enweghị isi, ntakịrị uto, na soluble na mmiri, ọ fọrọ nke nta ka ọ bụrụ ihe na-adịghị ike na ethanol, acetone, chloroform ma ọ bụ ether.

 

YTBIO Ndị na-eweta ntụ ntụ Tranexamic Acid Ngwaahịa niile bụ akụrụngwa emechara ọkara, ma dabara adaba maka ụlọ ọrụ nri ruru eru, ụlọ ọrụ nri ahụike, ụlọ ọrụ ihe ọ drinkụ drinkụ, ụlọ ọrụ ịchọ mma, ndị ahịa, ụlọ akwụkwọ, ụlọ ọrụ nyocha na ụlọ ọrụ ndị ọzọ ma ọ bụ ụlọ ọrụ nkesa metụtara ya. A naghị atụ aro oriri ozugbo.

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Product Atụmatụ

1) Nkwụsi ike ya dị mma karịa ihe ndị na-eme ka ọ dị ọcha na-acha ọcha n'ozuzu ya, na ọnọdụ okpomọkụ adịghị emetụta ya ngwa ngwa.

2) A na-etinye ya ngwa ngwa site na akpụkpọ ahụ, ọ bụghị naanị na ọ na-eme ka akpụkpọ ahụ dị ọcha, kamakwa ọ na-eme ka ntụpọ ahụ dịkwuo mfe, ka ọ dị ugbu a, ọ nwere ike ime ka nghọta nke ụda akpụkpọ ahụ dịkwuo mma na nkwụsịtụ nke patches akpụkpọ anụ mpaghara.

3) Ọ nwere ike mee ka ntụpọ gbara ọchịchịrị, ntụpọ edo edo, akara ihe otutu, wdg, nke na-abụkarị site na igbochi ọrụ tyrosinase na melanocytes iji belata mmepụta nke melanin site na oyi akwa basal nke epidermis, yana mmetụta na-acha ọbara ọbara na mkpali. .

4) Ọ bụ h igh nchekwa, ọ dịghị mkpasu iwe na akpụkpọ maka mpụga ojiji, na kasị elu itinye uche na ntecha bụ 2% ~ 3%.

Kedu ihe tranexamic acid na-eme?

Ịcha ọcha na ọkụ

① Na-egbochi mmeghachi omume tyrosinase

Tranexamic acid nwere usoro kemịkalụ yiri nke tyrosine ma nwee ike ịsọ mpi na tyrosine ozugbo, gbochie mmetụta tyrosinase na metabolism tyrosine, ma belata mmepụta melanin.

② Na-egbochi mwepụta nke prostaglandin E2

Na-ebelata ọrụ nke plasmin, na-egbochi mmekọrịta dị n'etiti keratinocytes na melanocytes, na-egbochi ntọhapụ nke prostaglandin E2 (PGE2) na keratinocytes, ma na-ebelata ọrụ tyrosinase nke melanocytes nke ụzarị ultraviolet na-ebute, si otú a na-ebelata mmepụta melanin.

③ Na-egbochi mmalite nke VEGFRs na nhazi nke protein na-emepụta melanin.

Tranexamic acid na-egbochi nnabata nke vaskụla endothelial growth factor receptors (VEGFRs) na ngosipụta nke protein na-emepụta melanin na melanocytes nkịtị mmadụ, na-ebelata ọrụ tyrosinase na itinye aka na mmepụta melanin.

④ Na-egbochi ịgbalite melanocyte nke UVB kpatara

Na-egbochi ọrụ melanocyte na-akpata UV site na ibelata proinsulin na-agbanwe enzyme 2 (PC2) na α-melanocyte-stimulating hormone (α-MSH).

⑤ Mee ka melanoma cell autophagy rụọ ọrụ

Na-egbochi mmepụta melanocyte site na ịgbalite usoro autophagy.

Lụọ ọgụ ịka nká

① Kwalite mmezi nke mgbochi anụ ahụ na mpaghara akpụkpọ anụ okpuru ulo

Na-egbochi ọrụ nke serine proteases na stratum corneum na okwu nke antimicrobial peptide LL-37 iji rụkwaa ihe mgbochi; na-egbochi plasmin, matrix metalloproteinases (MMPs) na trypsin iji rụkwaa mpaghara akpụkpọ ahụ okpuru ulo.

② Lụọ ọgụ megide ịka nká

Tranexamic acid na-eme ka njikọ hyaluronic acid dịkwuo elu site n'ịba ụba nke mkpụrụ ndụ epidermal, na-egbochi matrix metalloproteinases (MMPs) site na igbochi plasmin, si otú ahụ belata mmebi nke extracellular matrix (ECM) na dermis, ma nwee ike ibelata TNF-α n'ime ọbara. , IL-6 na ụdị ikuku oxygen na-emeghachi omume (ROS) iji meziwanye ịka nká nke anụ ahụ.

③ Mgbochi foto

Tranexamic acid nwere ike imeziwanye fotoaging nke UVB na-ebute site n'ịbawanye biogenesis mitochondrial, ma nwee ike imeziwanye fotoaging nke UVA site n'ịbawanye nkwupụta nke estrogen receptor-β n'elu sel mast na ịhazi homonụ hypothalamic-pituitary.

Lụọ mbufụt

① Gbochie nguzobe nke mkpụrụ ndụ ọbara uhie

Tranexamic acid na-egbochi oke ngosipụta na ịgbalite ndị na-anabata ihe uto VEGF na vaskụla endothelium, na-egbochi angiogenesis anụ ahụ, ma na-emezi erythema na ọnya ọnya gachara.

② Tranexamic acid nwere ike igbochi mbanye CD4+ T cell yana polarization cell

Na-egbochi mbanye CD4+ T cell na T cell polarization nke mmadụ na-akpata peptide antimicrobial LL37 ma na-arụ ọrụ mgbochi mkpali.

③ Tranexamic acid nwere ike igbochi ihe na-egbochi mkpali na chemokines

Belata okwu nke cytokines pro-inflammatory (interleukin 6 na tumor necrosis factor α) na chemokines (CCL10) iji mepụta mmetụta mgbochi mkpali.

④ Tranexamic acid nwere ike igbochi ntọhapụ nke leukotrienes na platelet ihe na-arụ ọrụ

Tranexamic acid na-ebelata ntọhapụ nke bradykinin site na igbochi plasmin. Ọ nwekwara ike igbochi ntọhapụ nke leukotrienes na platelet ihe na-arụ ọrụ site n'ibelata ọnụ ọgụgụ na ọrụ nke mkpụrụ ndụ mast, si otú a na-enwe mmetụta mgbochi mkpali.

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Kedu ihe kpatara enwere ike iji tranexamic acid mee ka ntụpọ dị ọcha?

Ugbu a, isi ụkpụrụ nke ịcha ọcha na ọkụ1. Na-egbochi ọrụ nke tyrosinase, si otú ahụ belata nguzobe nke melanin; 2. Kwalite metabolism nke epidermis; 3. Na-egbochi mbufụt nke anụ ahụ nwere ike ime.

Tranexamic acid na-ezute naanị isi nke mbụ na nke atọ. Ọ nwere ike ọ bụghị nanị na ịsọ mpi igbochi ọrụ tyrosinase, gbochie njikọ nke melanin, kamakwa na-egbochi ọrụ plasmin, melite mbufụt akpụkpọ na vasodilation. Ị nwere ike ịjụ na e nwere ọtụtụ ngwaahịa ịcha ọcha, gịnị kpatara eji akpọ ya "ọgwụ anwansi" maka ịcha ọcha? Nke a na-amalite site n'akụkọ ihe mere eme nke nchọpụta "tranexamic acid": tranexamic acid, nke a makwaara dị ka tranexamic acid, bụ ihe mmepụta lysine sịntetik bụ nke onye na-ahụ maka antifibrinolytic. N'afọ 1962, dọkịta nwanyị Japan bụ Utako Okamoto chọpụtara na ngwa mbụ abụghị maka ịcha ọcha, kama maka ọgwụ coagulation ọbara maka hemostasis mgbe ọmụmụ gasịrị.

Site n'iji tranexamic acid eme ihe n'ọtụtụ ebe, ndị mmadụ malitere ịchọpụta na ọ nwekwara "mmetụta dị n'akụkụ" na-adọrọ mmasị, bụ nke na-acha ọcha na iwepụ freckle. Mmetụta na-acha ọcha nke tranexamic acid pụtara nke ọma, na mmetụta ya na-ewepụ ntụpọ gbara ọchịchịrị dị ihe dị ka okpukpu 50 karịa nke vitamin C, yana ihe fọrọ nke nta ka ọ bụrụ okpukpu iri karịa nke acid mkpụrụ osisi. Nke a mere Tranexamic acid ọbụna ka a ma ama.

Mmetụta na-acha ọcha PK: Tranexamic Acid Vs Vitamin C, Niacinamide

Tranexamic acid nwere usoro ịcha ọcha dị iche na vitamin C na niacinamide. Niacinamide n'onwe ya enweghị mmetụta na tyrosinase nke na-emepụta melanin, mana ọ na-emetụta mbugharị nke melanin. Vitamin C nwere ike igbochi mmepụta nke melanin ozugbo, na-atụgharị otu nzọụkwụ (dopa na dopaquinone). Tranexamic acid na-egbochi mmepụta nke melanin na njedebe ihu, na-egbochi mbufe na mgbasa nke melanin nke emelarị na azụ azụ. Tranexamic acid na-abanye ngwa ngwa site na akpụkpọ ahụ, nwee ezigbo nkwụsi ike, okpomọkụ na gburugburu ebe obibi anaghị emetụta ya ngwa ngwa. Ọ naghị oxidize dị ka vitamin C, ọ dịghị eme ka ọ na-agbapụta dị ka niacinamide, ọ dịghịkwa ahapụ ntụpọ na-adịgide adịgide dị ka hydroquinone.

n'ihi na tranexamic acid ntụ ntụ nwere mmetụta ọgwụgwọ dị mma na nchekwa ndu, ọ bụ ngwaahịa mbụ nhọrọ maka ọgwụgwọ chlorasma ugbu a.

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Nyochaa akụkọ banyere Tranexamic Acid

ITEM

STANDARD

TNsonaazụ EST

Ọgwụ Tranexamic

≥99.0%

99.7% nke HPLC

Anụ ahụ & Kemịkalụ

ọdịdị

White crystalline ntụ ntụ

Kwuru

Solubility

Soluble na mmiri na glacial acetic acid, ọ fọrọ nke nta ka ọ bụghị soluble na ethanol na acetone (96%)

Kwuru

PH

10.0-11.0

10.45

Ọnwụ na nkụ

≤8.0%

3.40%

Fọduru na mgbanye

≤0.1%

0.01%

njikọ bekee

A≤0.1%, B≤0.2% C≤0.1%, D≤0.1%

A=0.032%, B=0.0976% C=0.0093%, D=0.0076%


Mkpokọta adịghị ọcha (ma e wezụga A, B) ≤0.2%

Mkpokọta adịghị ọcha (ma e wezụga A, B)=0.017%

arọ metal

Total arọ ọla

≤10ppm

<10pm

Sulfate ntụ

≤0.1%

chloride

≤140ppm

<140pm

As

≤2.0ppm

<2.0pm

Nnwale Microbiological

Ọnụ Ọgụgụ Ogugu

≤1,000cfu / g

<10cfu/g

E.Coli

≤10cfu / g

<0.3cfu/g

Salmonella

-adịghị mma

-adịghị mma

Asambodo

YTBIO bụ a Ndị na-eweta ntụ ntụ Tranexamic Acid gbara mbọ inye ndị ahịa ihe kacha mma Tranexamic Acid Powder Suppliers ntụ ntụ na ọrụ ka onye ọ bụla na-azụ ahịa nwee ike ịnụ ụtọ nri eke, ahụike yana oke mma. Ọ bụrụ na ị nwere ajụjụ ọ bụla ma ọ bụ mkpa gbasara ngwaahịa anyị, biko nweere onwe gị ịkpọtụrụ anyị, anyị ga-azaghachi gị ozugbo enwere ike.

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