Oat peptide

Kedu ihe bụ Avena Sativa (Oat) Peptide?

Oat peptide bụ mgbagwoju osisi nke ewepụtara na oat alpine ma nwee protein oat na oat beta-glucan. Ọ nwere ike ịmepụta ihe nkiri nchebe na akpụkpọ ahụ, mee ka ọ dị nro ma mee ka ọkpụkpụ dị mma dị nro, kpochie mmiri anụ ahụ, mee ka akpụkpọ ahụ dịkwuo mma, na-emetụ n'ahụ, ma gbochie ịka nká.

Dabere na usoro mmepụta ihe dị elu pụrụ iche, a na-achọpụta peptides obere molekul na-arụ ọrụ site na ụzọ HPLC na GPC. The molekụla arọ arọ nke ngwaahịa bụ tumadi lekwasịrị n'etiti 2000 na 15000 Da, na nwere ọnụ ọgụgụ buru ibu nke hydrophilic otu.

Ọ nwere mmetụta ịchọ mma dị mma ma jiri ya mee ihe na ngwaahịa nlekọta anụ ahụ. Ọ nwere ihe ndị na-emepụta ihe nkiri dị mma, nwere ike ịmepụta ihe nkiri na ntinye uche dị ala, tinye ma ọ bụ kewapụ obere ihe molekụla, banye n'ime akpụkpọ ahụ na ntutu isi, na-etolite mkpuchi nchebe n'elu akpụkpọ ahụ na ntutu. Ọ nwere ọrụ nke igbochi ọrụ MMP-1 na ịbawanye ọdịnaya collagen na akpụkpọ ahụ. Ọ nwere ike igbochi mmeghachi omume agbụ na-emerụ ahụ nke ukwuu n'akpụkpọ ahụ, si otú ahụ na-edobe iguzosi ike n'ezi ihe nke nhazi akpụkpọ ahụ, na-egbochi ịcha akpụkpọ ahụ, na ịkwalite ngbanwe akpụkpọ ahụ. Obere molekul bioactive peptide n'ime Avena Sativa Peptide yiri ihe na-eme ka mkpụrụ ndụ na-eto eto (EGF), nke nwere ike ime ka mmụba cell dịkwuo ngwa, kwalite metabolism anụ ahụ, mee ka akpụkpọ ahụ rụọ ọrụ, mee ka akpụkpọ ahụ dịkwuo ike, na-eme ka akpụkpọ ahụ na-egbuke egbuke ma maa mma.

Usoro mmịpụta ahụ tozuru oke ma jiri ya mee ihe n'ọtụtụ ngwaahịa mara mma. A na-anụcha ya site na protein oat dị elu site na usoro enzymatic hydrolysis nke nkwadebe enzyme ngwakọta. Ọdịdị ya yiri ihe na-eme ka mmiri dị n'okike (NMF). Ọ nwere ihe ndị na-eme ka mmiri dị mma ma nwee ike banye ngwa ngwa n'ime akpụkpọ ahụ iji nye ihe na-eme ka mmiri dị omimi.

Olee uru?

Na-akwalite mmụba fibroblast

Cytokines (CK) bụ okwu n'ozuzu maka protein na-arụ ọrụ dị ala ma ọ bụ polypeptides na-emepụta na nzuzo site na mkpụrụ ndụ (sel ndị na-alụso ọrịa ọgụ na sel ndị na-adịghị egbochi ọrịa). Mgbe e bibiri protein ndị dị na akpụkpọ ahụ, ha na-aghọ ọtụtụ obere iberibe a na-akpọ "cytokines", nke na-ebunye akara na akpụkpọ ahụ ma kwalite mmepụta nke mkpụrụ ndụ ọhụrụ na akpụkpọ ahụ.

Nwere obere peptides molecule, nke yiri cytokines, akpụkpọ ahụ na-ekpehie ikpe. Avena Sativa Peptide dị ka cytokines, si otú ahụ na-eme ngwa ngwa n'ịbawanye cell, na-akwalite metabolism anụ ahụ, na-eme ka akpụkpọ ahụ dịghachi ndụ.

Na-akwalite mmụba fibroblast

A gbanyere fibroblast akpụkpọ anụ nkịtị n'ime efere olulu mmiri 96. Na DMEM nke nwere serum 5% nke anụ ọhịa, ihe a ga-achọpụta na-eme ka ọ bụrụ ngwọta mmiri ma tinye ya ugboro anọ iji mee ka mkpụrụ ndụ na-eto ngwa ngwa. . Isi ihe na-eto eto fibroblast jere ozi dị ka njikwa dị mma. Omenala cell kwụsịrị mgbe awa 96 gachara.

N'ime nsonaazụ ule nke ọtụtụ ihe, oat na-arụ ọrụ peptide gosipụtara ọrụ na-akpali akpali kachasị ike, bụ nke dị elu karịa ihe atọ ndị ọzọ akpụkpọ anụ. peptides arụpụtara n'ahịa egosighi mmetụta na-abawanye na fibroblasts akpụkpọ ahụ mmadụ. Osikapa peptides na peptides soybean nwere mmetụta nchịkwa dị nta na nnwale ahụ.

Belata akpụkpọ anụ ahụ

N'ime nnwale ahụ, a gwara ndị ọrụ afọ ofufo ka ha tinye ihe ịchọ mma nwere 10% mmanụ aṅụ peptide n'ime ogwe aka ha otu ugboro n'ụbọchị n'ụtụtụ na mgbede. Mgbe izu 4 nke na-aga n'ihu na-aga n'ihu, enwere ike ịhụ nke ọma na akpụkpọ anụ ahụ aghọwo ihe siri ike ma dị nro.

Ọrụ mgbochi wrinkle

E kewara ndị ọrụ afọ ofufo 20 ụzọ abụọ ma mee nnwale ntụnyere mmetụta. N'ime ule ahụ, otu ndị ọrụ afọ ofufo tinyere ihe ịchọ mma nwere 10% Avena Sativa (Oat) Peptide n'anya ha, ebe ndị ọzọ na-etinye ihe ịchọ mma na otu placebo maka ntụnyere nnwale.

Nsonaazụ nnwale gosiri na 80.5% nke ndị nọ n'ime otu na-eji ọdịnaya 10% nwere mmetụta mgbochi mgbochi, na 90% nke ndị ọrụ afọ ofufo gosipụtara mmetụta dị ukwuu n'ime nkeji 5 iji. Naanị 23.5% nke ndị nọ na placebo nwere mmetụta mbelata wrinkles.

Ọrụ moisturize

Ntụle nke moisturize Njirimara n'etiti oat peptides na hyaluronic acid

Nnwale ahụ jiri 5% Avena Sativa (Oat) Peptide na 0.1% hyaluronic acid tụnyere ihe ndị na-eme ka mmiri dị nro.

Enwere ike ịhụ na mmetụta moisturize nke Avena Sativa (Oat) Peptide na ntinye 5% dị mma karịa nke hyaluronic acid. N'oge mbụ, ọ dị ntakịrị ala karịa hyaluronic acid, ma mgbe ihe dị ka nkeji 45 gachara, mmetụta ya na-ekpo ọkụ na-amalite ịdị mma karịa nke otu ntinye uche. nke hyaluronic acid. Site na elekere 1 ruo awa 4 mgbe ngwa ahụ gasịrị, mmetụta moisturize nke Avena Sativa (Oat) Peptide kwụsiri ike. Ọ bụ ezie na mmetụta moisturize nke hyaluronic acid dịkwa mma, mmetụta mmiri ya na-ebelata nke ukwuu ka oge na-aga. E jiri ya tụnyere Avena Sativa (Oat) Mmetụta moisturize Peptide na-adịte aka karịa, rụọ ọrụ nke ọma ma kwụsie ike.

Ọ nwekwara ike igbochi ọrụ protease ma nwee mmetụta antioxidant; ọ nwekwara ike inye aka ịbanye, na-enyere akpụkpọ ahụ aka ka ọ nweta ihe ndị ọzọ na-edozi ahụ nke ọma; n'otu oge ahụ, ọ nwere ike inye anụ ahụ nri na-edozi ahụ, mee ka akpụkpọ ahụ dịkwuo mma, mee ka akpụkpọ ahụ dịkwuo mma nke ọma, ma belata akpụkpọ anụ ahụ. Enwere ike itinye ya ozugbo site na akpụkpọ ahụ site na onye na-ebu ya. Ọ nwere njirimara nke ngwa ngwa ngwa ngwa na ike dị ala n'oge usoro ntinye. Mgbe etinyechara ya, ọ nwere ike iwepụ mmịnye n'ụdị amino acid residues (PAA) n'usoro ịkwalite mmụba cell. Amino acids na-asọrịta mpi iji kwalite njikọ protein ngwa ngwa.

Obere molecule bioactive peptides dị na Avena Sativa (Oat) Peptide dị nnọọ ka ihe na-eme ka mkpụrụ ndụ na-eto eto, nke nwere ike ime ka mmụba cell dịkwuo elu, na-akwalite metabolism anụ ahụ, mee ka akpụkpọ ahụ rụọ ọrụ, na-ebelata akpụkpọ anụ ahụ, na-eguzogide radicals free, ma mee ka akpụkpọ ahụ na-egbuke egbuke.

Ọ nwekwara mmetụta nke igbochi ọrụ MMP-1 na ịba ụba ọdịnaya nke collagen na akpụkpọ ahụ. Ọ nwere ike igbochi mmeghachi omume yinye nke na-emerụ ahụ nke ukwuu n'akpụkpọ ahụ, si otú ahụ na-edobe iguzosi ike n'ezi ihe nke nhazi akpụkpọ ahụ, na-ejigide nhịahụ akpụkpọ ahụ, ma na-egbochi ịcha akpụkpọ ahụ na ngbanwe.

Oat β-glucan dị na Avena Sativa (Oat) Peptide nwere mmetụta mgbochi ịka nká nke ọma ma nwee ike ime ka wrinkles dị mma dị mma, na-abawanye nkwụ akpụkpọ ahụ, ma melite ọdịdị akpụkpọ ahụ. β-glucan nwere usoro ihe omimi nke ahịrị ma nwee ezigbo ihe mgbochi ịka nká. Ngwongwo absorption nke transdermal na-akwalite fibroblasts iji mepụta collagen, kwalite ọgwụgwọ ọnya, na ịrụzi akpụkpọ ahụ mebiri emebi.

Nhazi ihe

Enwere ike itinye ya ozugbo site na akpụkpọ ahụ site na onye na-ebu ya. Ọ nwere njirimara nke ngwa ngwa ngwa ngwa na ike dị ala n'oge usoro ntinye. Mgbe etinyere oat peptide, ọ nwere ike iwepụ ụdị amino acid residues (FAA) n'usoro ịkwalite mmụba cell. Amino acids na-asọrịta mpi n'oge nnabata, si otú ahụ na-akwalite njikọ protein ngwa ngwa.

Nke ka mkpa bụ na ihe mejupụtara protein ndị a na-ewepụta na oat yiri nnọọ ihe na-akpata uto mkpụrụ ndụ. Akpụkpọ ahụ na-echekarị protein oat dị ka ihe na-ebuwanye ibu cell, si otú a na-eme ka mmụba cell na-adị ngwa ngwa ma na-akwalite metabolism dum. Tụkwasị na nke ahụ, ihe ndị dị na peptide dị na ngwaahịa ahụ nwere ọnụ ọgụgụ dị ukwuu nke ìgwè hydrophilic ma bụrụ ihe ndị na-eme ka mmiri dị ukwuu, nke nwere ike ịkwalite ma hụ na mmetụta na-eme ka mmiri dị nro nke ngwaahịa ahụ mgbe agbakwunyere ya na ihe ịchọ mma.

Antioxidant nyocha

Ụzọ nyocha

Ghichaa oat polypeptide na mmiri deionized iji nweta ihe ngwọta nke mkpokọta dị iche iche, tụọ njirimara antioxidant ya (gụnyere DPPH free radical scavenging rate, hydroxyl free radical scavenging rate, Fe2+ chelating ike), wee gbakọọ scavenging nke DPPH free radicals, hydroxyl free radicals na chelating. ikike. IC50 nke Fe2+ ka atụnyere IC50 nke ọkọlọtọ antioxidant.

Mkpebi nke ikike mkpochapụ radical free DPPH:

Ọgụgụ na-egosi mmekọrịta dị n'etiti Avena Sativa (Oat) Peptide na VC itinye uche na DPPH free radical scavenging ọnụego. Enwere ike ịhụ site na ọnụ ọgụgụ a na ka ntinye uche (0-8.40 mg / mL) na-abawanye, ọnụ ọgụgụ scavenging free DPPH ya na-aga n'ihu na-abawanye. IC50 nke Avena Sativa (Oat) Peptide na iwepu DPPH free radicals (ya bụ, ntinye nke Avena Sativa (Oat) Peptide mgbe ọnụ ọgụgụ DPPH na-ekpochapụ bụ 50%) bụ 2.63 mg / mL.

Mkpebi nke ike mkpochapụ hydroxyl radical (•OH):

Hydroxyl radical (• OH) nwere ikike siri ike iji nweta electrons, ya bụ, ikike oxidizing, na Avena Sativa (Oat) Peptide nwere otu ndị na-enye onyinye electron dị ka sulfhydryl na phenolic hydroxyl otu na amino acid mejupụtara ya, nke nwere ike ime ka oxidation- Mbelata mmeghachi omume na hydroxyl radicals. Site na nke a na-ekpochapụ radicals free radicals. Mmekọrịta dị n'etiti Avena Sativa (Oat) Peptide na VC itinye uche na hydroxyl radical scavenging ọnụego ka egosiri na ọnụ ọgụgụ a.

Enwere ike ịhụ site na ọnụ ọgụgụ ahụ na ka ntinye uche na-abawanye, ọnụ ọgụgụ scavenging hydroxyl radical na-abawanye nke ọma. Mgbe ịta ahụhụ ruru 0.30 mg / ml, ọnụ ọgụgụ scavenging hydroxyl radical ruru 95.6%. Mmetụta ya na scavenging hydroxyl free radicals dị nnọọ mma karịa nke VC. Avena Sativa (Oat) Peptide nwere IC50 nke 0.15mg/mL maka scavenging hydroxyl radicals.

Mkpebi nke ike chelating Fe2+:

Fe2+ ​​nwere ike ịkwalite peroxidation lipid iji mepụta radicals efu site na mmeghachi omume Fenton. Ya mere, ibelata mkpokọta Fe2+ n'oge mmeghachi omume Fenton nwere ike igbochi mmebi oxidative na ahụ mmadụ. Nnwale a na-amụ ike nke oat peptides chelate Fe2+, na-eji EDTA dịka ọkọlọtọ maka ntụnyere. E gosipụtara nsonaazụ ya na eserese 3-12. N'ime oke ịta ahụhụ a na-enyocha, ka ntinye nke Avena Sativa (Oat) Peptide na-abawanye, Fe2 + chelation ọnụego ya na-aga n'ihu na-abawanye. Avena Sativa (Oat) Peptide nwere IC50 nke 0.36 mg/mL maka chelating Fe2+.

Nsonaazụ nha

IC50 maka scavenging DPPH free radicals bụ 2.63 mg / mL, IC50 maka scavenging hydroxyl free radicals bụ 0.15 mg / mL, na IC50 maka Fe2 + chelation bụ 0.36 mg / mL, na-egosi na Avena Sativa (Oat) Peptide nwere ezigbo antioxidant Njirimara. .

Avena Sativa (Oat) Onye na-eweta Peptide

Yuantai Organic Bio na-agba mbọ inye ndị ahịa ihe kacha mma Avena Sativa (Oat) Peptide na ọrụ ka onye ọ bụla na-azụ ahịa nwee ike ịnụ ụtọ nri eke, ahụike yana oke mma. Ọ bụrụ na ị nwere ajụjụ ọ bụla ma ọ bụ mkpa gbasara ngwaahịa anyị, biko nweere onwe gị ịkpọtụrụ anyị, anyị ga-azaghachi gị ozugbo enwere ike.

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