Idebenone ntụ ntụ

Kedu ihe bụ idebenone ntụ ntụ?

Idebenone ntụ ntụ bụ ogige lipophilic nke ukwuu nke nwekwara ike ịgbaze site na iji mmanụ mkpụrụ vaịn kwesịrị ekwesị kpo oku. Ọ dị ka coenzyme Q10 na nhazi ya. Dị ka antioxidant na-arụ ọrụ nke ọma, ọ nwere mmetụta ịchọ mma dị ka scavenging free radicals, igbochi lipid peroxidation, na-egbochi mbufụt, igbochi DNA mmebi, photoprotection, ibelata pigmentation, melite mma ahịrị, wrinkles na afọ ntụpọ. 

Ugbu a, a na-eji idebenone mee ihe n'ụdị ihe ịchọ mma. Otú ọ dị, n'ịtụle iwe ya na nkwụsi ike na-adịghị mma, a chọrọ nyocha ọzọ na idebenone microemulsion iji mee ka ọ dịkwuo irè. Eji n'enweghị nsogbu na ịchọ mma. Idebenone bụ ngwakọta organic nke nwere usoro molekụla C19H30O5. Ọ bụ kristal edo edo ma ọ bụ ntụ ntụ na-enweghị isi. Oke siri ike igbari na mmiri, kemgwucha soluble

Ọ na-agbaze na chloroform, methanol ma ọ bụ ethanol zuru oke, na-agbaze ngwa ngwa na ethyl acetate, na-adịghị ike na n-hexane. A na-eji ya eme ihe ịchọ mma iji mebie radicals efu ma gbochie lipids

Ọ nwere ọrụ ịchọ mma dị ka plasma peroxidation, mgbochi nke mbufụt, mgbochi nke DNA mebiri emebi, photoprotection, na mbelata pigmentation.

Ụkpụrụ omume:

Idebenone ntụ ntụ nnukwu Nke a bụ analog nke coenzyme Q10. Coenzyme Q bụ quinone na-agbaze abụba na-adị n'ọtụtụ ebe n'ime anụ ahụ ma nwee ike ịkwalite mmeghachi omume phosphorylation oxidative.

ọrụ iji zaghachi ma chebe iguzosi ike n'ezi ihe nke biofilms. Ebe dị iche iche nke coenzyme Q nwere ọnụọgụ dị iche iche nke nkeji isopentenyl n'agbụ akụkụ ha. Ụmụ mmadụ na mammals bụ

Nkeji 10 nke isopentene, yabụ aha ya bụ Coenzyme Q10. Coenzyme Q na-arụ ọrụ dị mkpa na ntụgharị proton na nnyefe elektrọn n'ime agbụ iku ume na ahụ. Ọ bụ akụkụ dị mkpa nke iku ume cellular.

Na activator nke cell metabolism, ọ bụkwa ihe dị mkpa antioxidant na-abụghị kpọmkwem immuno enhancer.

Ọrụ nke idebenone

1. Magburu onwe free radical scavenger

Idebenone ntụ ntụ nwere ikike mkpochapụ n'efu n'etiti ọtụtụ antioxidants nkịtị. N'otu ntinye uche ahụ, idebenone nwere ikike yiri nke ahụ iji kpochapụ DPPH na AAPH dị ka mmiri na-edozi mmiri vitamin E. Ikike ya iji kpochapụ ABTS free radicals, tyrosine free radicals na peroxynitrite anions bụ ugboro 50 karịa nke vitamin E. %. Idebenone, ascorbic acid na vitamin E nwere ike iwepụ radicals n'efu na mkpokọta dị ala (10nmol / L). Coenzyme Q10 na kinetin kwesịrị ịdị na mkpokọta 100nmol/L na 1000nmol/L n'otu n'otu iji gosi ike ha ịbọ ọbọ free radicals.

2. Na-egbochi peroxidation lipid

E jiri ya tụnyere ascorbic acid (> 20mol / L), a-tocopherol (100rtmol / L), na glutathione (50tzmol / L), obere ịta nke idebenone (10Fmol / L) gosipụtara antioxidant siri ike Ọ nwere ike igbochi nguzobe nke peroxides lipid.

3. Na-egbochi mbufụt ma rụkwaa cutin

Ezinụlọ Caspase (caspase) bụ usoro mkpali ma na-arụ ọrụ dị oke mkpa na mgbasa ozi apoptosis, nke Caspase-3 bụ ihe dị mkpa. N'ime nnwale ahụ, a na-eji 0.5t, mol/L diethyl maleate na 0.1Fmol/L hydrogen peroxide rụọ ọrụ Caspase-3 n'otu n'otu, si otú a na-egosipụta ogo nke apoptosis cell. Nnyocha egosiwo na 0.5 ~ mol / L idebenone nwere ike ibelata ogo apoptosis nke diethyl maleate na hydrogen peroxide na-ebute, si otú a na-egbochi ihe omume nke mbufụt na imeziwanye ike ịrụzi anụ ahụ.

4. Gbochie ma gwọọ mmebi DNA

Nnyocha e mere egosiwo na na zuru ezu UVB irradiation, mmepụta nke photoproducts na keratinocytes na-enweghị ihe ọ bụla antioxidants bụ 53%, mmepụta nke photoproducts na idebenone bụ 23%, na photoinhibition ọnụego bụ 43%, mgbe vitamin C, agonist The photoproduct inhibition ọnụego. coenzyme, coenzyme Q10 na alfa-lipoic acid bụ 36%, 36%, 4% na 0% n'otu n'otu. Idebenone na-ebelata nke ọma mmebi UVB na DNA.

5. Na-egbochi mmebi ọkụ

Nnyocha ahụ chọpụtara na mgbe a na-eji UVB mee ka akpụkpọ ahụ dị ọcha nke ejiri antioxidants mee ihe, mkpụrụ ndụ anwụ anwụ nke akpụkpọ ahụ nke 0.5 idebenone belatara site na 38% ma e jiri ya tụnyere oghere, ebe vitamin E, kinetin, coenzyme Q10 na alpha-lipoic. Acid bụ n'otu n'otu Mbelata nke 30%, 20%, 10%, 9% na 0%. Enwere ike ịhụ na idebenone nwere mmetụta kachasị dị mkpa na igbochi foto mmebi.

6. Na-egbochi mmepụta nke melanin

Mmetụta mgbochi nke idebenone na melanin na-ejikọta ya na ego mgbakwunye ya. Ọnụ ọgụgụ dị elu nke idebenone na hydroquinone nwere mmetụta yiri ya; Mgbe ụfọdụ dilution gasịrị, mmetụta mgbochi nke hydroquinone na melanin na-apụ n'anya, ebe idebenone dị ala ka na-egosi mmetụta mgbochi.

Njirimara anụ ahụ na nke kemịkal

Idebenone, nke a makwaara dị ka Hydroxydecyl Ubiquinone, bụ kristal edo edo ma ọ bụ ntụ ntụ kristal. Ọ bụ ngwakọta lipophilic na n'ụdị ya dị ka coenzyme Q10, ntụgharị Ubiquinone. Molecule ahụ dị 66% pere mpe karịa Coenzyme Q10, yabụ na ọ nwere oke ọsọ na ịdị irè nke ịbanye n'ime akpụkpọ ahụ. Dị ka antioxidant na-arụ ọrụ nke ọma, ọ nwere ọrụ ịchọ mma dị ka ikpochapụ free radicals, na-egbochi peroxidation lipid, na-egbochi mbufụt, na-egbochi mmebi DNA, nchebe foto, na ibelata pigmentation.

Ngwa nke Idebenone ntụ ntụ:

Nwere mmetụta agba na ngwaahịa

Kwesịrị ekwesị maka ụdị anụ ahụ niile ma gbanwee ọdịdị ngwaahịa

Enwere ike iji toner, ihe mkpuchi ihu na ngwaahịa nlekọta anụ ahụ dị iche iche dị ka antioxidant

Idebenone nwere ihe mgbu ngwa ngwa na ngwaahịa nlekọta anụ ahụ:

① Na-adịghị akwụsi ike na ọkụ na okpomọkụ, dị mfe imebi na gbanyụọ;

② Molecule idebenone bụ nnukwu polar ma sie ike ịbanye na akpụkpọ ahụ wee banye n'akụkụ akụkụ nke mgbochi ịka nká na sel nke akpụkpọ ahụ;

③ Idebenone enweghị ike ịsacha n'ime mmiri ma nwee ndakọrịta adịghị mma na ntọala ịchọ mma.

ngwọta:

Nanocarriers nwere ike imeziwanye ìhè na nkwụsi ike nke idebenone nke ọma. Ha nwere ndakọrịta dị elu ma dị mfe ijikọta ya na ntọala dị iche iche dị ka ude / essences / lotions / mmiri / ihe mkpuchi ihu, ma dị mma maka usoro transperent.

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Idebenone ntụ ntụ Supplier

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