Hydroxypinacolone Retinoate ntụ ntụ

Nkọwa: 98% ntụ ntụ
10% ude edo edo
Usoro nchọpụta: HPLC
Ịrụ ọrụ: mgbochi ịka nká, ịcha ọcha
Mbupu ọsọ: 1-3 ụbọchị
Ngwaahịa: Ọ dị na ngwaahịa
Asambodo: HACCP, HALAL, KOSHER, ISO9001, ISO22000, FDA
MOQ: 25KG
Ngwugwu: 25kg / gbọmgbọm
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Kedu ihe bụ Hydroxypinacolone Retinoate?

Hydroxypinacolone retinoate ntụ ntụ bụ ihe nrụpụta retinol nke nwere ọrụ nke ịhazi metabolism nke epidermis na stratum corneum. Ọ nwere ike iguzogide ịka nká, belata seborrhea, na-emegharị pigmenti epidermal, ma gbochie ịka nká na mgbochi akpụkpọ ahụ. Ihe otutu, ịcha ọcha na mmetụta ọkụ. Ọ na-eme ka mmetụta dị ike nke retinol na-ebelata ma na-ebelata iwe ya. A na-eji ya ugbu a maka mgbochi ịka nká na igbochi nlọghachi nke otutu.

HPR ntụ ntụ (HPR), ụdị retinoid ọhụrụ, bụ VA ewepụtara ọgbọ nke atọ, vitamin A dị nro na nke na-arụ ọrụ nke ọma karị, nwere mgbochi ịka nká, mgbochi ihe otutu, na ihe na-acha ọcha. Ọ nwere ọrụ dị ka ntụpọ ọkụ na ịchịkwa epidermal metabolism, a na-ejikwa ya na ihe ịchọ mma, ọgwụ, nlekọta onwe onye na mpaghara ndị ọzọ.

Dị ka ọgbọ ọhụrụ nke ihe mgbochi ịka nká na ezinụlọ vitamin A, HPR nwere ihe pụrụ iche, tumadi n'ihi nhazi kemịkal pụrụ iche.

Nhazi nke HPR na-enye ya ohere ịpụ na usoro ntụgharị ọdịnala nke klas A (ester → mmanya → aldehyde), wee gbanwee ya ka ọ bụrụ acid ngwa ngwa, ma nwee ike jikọta ya na ndị na-anabata retinoic acid cellular (RARs).

Omenala retinol esters kwesịrị ịnata hydrolysis na oxidation nzọụkwụ abụọ n'ime akpụkpọ ahụ ka ọ bụrụ retinoic acid tupu ha enwee ike ịdị irè. Ntughari arụmọrụ dị ala, yana ịba ụba usoro onunu ogwu ga-ebute iwe.

HPR bụ ester dabere na retinoic acid, nke nwere ike ime ihe ozugbo site na-akpali ndị na-anabata ya na-enweghị mgbanwe nke metabolic.

Olee uru?

Dị nwayọọ

Ndị ọkà mmụta sayensị tụlere mmetụta mgbochi ịka nká na mgbakasị ahụ nke ọtụtụ vitamin A (gụnyere HPR, trans-retinoic acid, retinol, retinaldehyde, na retinyl palmitate) n'ụdị in vitro nke akpụkpọ ahụ mmadụ. Ọmụmụ ihe ahụ chọpụtara na mbufụt nke HPR na-ebute (nke IL-1a akara) adịghị ike karịa retinoic acid. Na ntinye nke ugboro 10, cytotoxicity dị ntakịrị. Ya mere, HPR bụ ihe kwụsiri ike na nke dị nro karịa retinoic acid ma enwere ike iji ya mee ihe na ịchọ mma.

Dị irè karị

Mgbochi ịka nká na mgbochi wrinkle

Iji ngwaahịa hydroxypinacolone retinoate nwere, a na-ahụ olu dent, wrinkles na ọmarịcha ahịrị onyonyo anakọtara na mpaghara site na isiokwu ụbọchị 0 (W0), ụbọchị 14 (W14), na ụbọchị 28 (W28). Mgbe ị na-eji ihe nlele ọbara nke nwere WL-HPR1130 maka izu 2 na izu 4, olu nke dents na nkuku anya, wrinkles na ahịrị ọma nke isiokwu ndị ahụ gosipụtara mgbanwe dị ịrịba ama, na-egosi usoro nke mbelata.

Na-akwalite metabolism nke keratin

Hydroxypinacolone Retinoate ntụ ntụ (HPR) nwere ike ibelata pores, belata akpụkpọ anụ ahụ ma mee ka akpụkpọ ahụ dịkwuo mma ma dị mma site n'ịkwalite metabolism nke keratin, ikwe ka keratinocytes dị iche iche, na ịkwalite njikọ nke interkeratin lipids.

HPR na-ebelata nkwụsị nke ntutu isi site na keratin metabolism, na-egbochi mmepụta mmanụ site na sebaceous glands, si otú ahụ na-ebelata ihe otutu na ihe otutu, na-enweta nkwụsị na nkwụsị nke nsị anụ ahụ. Ọ nwekwara ike mee ka mpụ nke melanocytes dị ngwa ma belata mmepụta nke melanocytes site na keratin metabolism, si otú ahụ nweta mmetụta na-acha ọcha.

Enwekwu ike

Ndị nyocha ahụ nwalere fotoensitivity nke retinoids. N'ime vitamin niile a nwalere, retinyl palmitate (Rpal) na beta carotene (βcal) na-enwekarị ike ịdaba na photodegradation na ọ fọrọ nke nta ka ọ bụrụ nke zuru oke mgbe otu izu gasịrị ìhè. , ebe hydroxypinacolone retinoate (HPR) na-eweda naanị 40% ka otu izu gachara. Na nkezi, ọkụ nwere mmetụta kacha nta na nkwụsi ike HPR nke vitamin niile a nwalere.

Na mgbakwunye, dị ka data nnwale nke akwụkwọ ahụ si dị, n'ime nnwale nkwụsi ike ogologo oge nke simulated (dobere na 25 Celsius C, iru mmiri 60% maka ọnwa 6), HPR ka kwụsiri ike na usoro ahụ (nke agbanwebeghị site na mbụ 95. % ọdịnaya); Nkwụsi ike siri ike Na nyocha mmekọahụ (40 ℃, gburugburu ikuku ultraviolet), HPR ka kwụsiri ike na usoro ahụ. Maka ọtụtụ usoro klaasị A ndị ọzọ, ewedara n'iyi pụtara ìhè.

e ji mara

Anyị na-ekwu maka mgbanwe agbụ akụkụ nke retinoids na mbụ. Gịnị mere anyị kwesịrị iji mepụta n'akụkụ yinye mgbanwe? N'ihi na ọ nwere ike iweta njirimara dị iche iche. Retinol dị mma, mana ọ naghị akwụsi ike ma na-akpasukwa iwe. Enwere ike idozi nsogbu ndị a site n'ịgbanwe agbụ akụkụ, dị ka retinyl palmitate, nke dị nro karị. Otú ọ dị, nsogbu nke ngbanwe ngbanwe n'akụkụ akụkụ bụ na a ga-emetụta ịdị irè n'ihi mmụba nke usoro ntụgharị. Nke a bụ otu maka vitamin C, vitamin E na ihe ndị ọzọ. Ọ dabara nke ọma, enwere ọtụtụ ụzọ isi gbanwee ụdọ akụkụ, ndị nyocha nwere ike gbanwee nhazi ahụ n'ụzọ dị iche iche, wee họrọ ihe ndị ahụ dị nro ma dị mma. N'ihe gbasara retinol, enwere m ihu ọma ịchọta hydroxypinacolone retinoate (HPR), nke bụ naanị retinoic acid + pinacol.

Mmetụta nke iji pinacol mgbanwe bụ mmetụta kpọmkwem, obere ihe dị arọ molecular, mfe transdermal absorption, obere iwe, na nkwụsi ike dị elu. Enwere ike ịsị na ọ nwere uru doro anya karịa ụdị retinoids ndị ọzọ. Nchịkọta nyocha nke Ruth et al., gụnyere na akwụkwọ akụkọ gbasara akpụkpọ ahụ ama ama JID, jiri ụdị akpụkpọ anụ in vitro tụnyere ihe mgbochi ịka nká na mgbakasị ahụ nke retinoids dị iche iche, gụnyere HPR, trans-retinoic acid, na retinoids. Mmanya, retinaldehyde, retinyl palmitate. Achọpụtara na n'otu ntinye uche ahụ, HPR nwere mmetụta siri ike na ọkwa nke mkpụrụ ndụ ihe nketa karịa retinol, retinaldehyde, na retinyl palmitate, na na ntinye nke ugboro 10, cytotoxicity dị ntakịrị, ma n'ogo ederede adịghị arụ ọrụ karịa. trans-retinoic acid. E jiri ya tụnyere njikwa a na-agwọghị ya, HPR kwalitere n'ụzọ dị ukwuu na njikọ nke procollagen. Nyocha akụkọ ihe mere eme gosiri na ọnụ ọgụgụ kasị elu nke HPR nwere mmetụta siri ike karịa trans-retinoic acid, ma mbufụt kpatara (nke IL-1a akara) adịghị elu karịa nke ikpeazụ. Dị ike. Dabere na nsonaazụ ndị a, a kwenyere na HPR bụ ihe ọzọ na retinoic acid maka mgbochi ịka nká, mana ọ nwere mmetụta dị nta nke anụ ahụ. Vincenzo Bettoli et al duziri ọmụmụ ihe ọnwa iri na abụọ iji nyochaa ikike nke usoro nwere HPR na retinol (Biretix gel®) iji gbochie nlọghachi nke otutu. Ndị ọrịa ahụ buru ụzọ were ọnụ ọnụ isotretinoin maka ọgwụgwọ na ọkwa mbụ ruo mgbe ahụ kwụsịrị. Mgbe ahụ, ha banyere n'ọgbọ nke abụọ ma jiri otu ụdị usoro a kwa ụbọchị maka ọnwa 12. Achọpụtara na 12% nke ndị ọrịa laghachiri azụ. Ndị ọrịa ahụ kwadoro usoro ahụ nke ọma ma ọ nweghị mmeghachi omume ọjọọ a kọrọ. , na-egosi na usoro nwere HPR na retinol dị mma, na-anabata ma dị irè. Ọmụmụ ụlọ ọgwụ ọzọ nke S. Veraldi et al. nwekwara HPR na retinol na usoro a, yana papain. A na-eji ya na ndị ọrịa 15.38 acne maka izu iri na abụọ n'usoro iji nyochaa mmetụta na ihe otutu. E belatara ọnya akpụkpọ ahụ site na nkezi nke 98%, na naanị 12% nke ndị ọrịa nwere ahụ erughị ala mpaghara. Nnyocha ahụ chọpụtara na ọ nwere HPR, retinol, na papain. Emebere ka ọ dị mma ma dị irè maka nlekọta ihe otutu. Tụkwasị na nke ahụ, ule ndị dị mkpa nke Nanjing Anyike mere gosiri na site na ntinye nke 40.8% dị ka ihe nyocha, ọ dịghị mmeghachi omume na-adịghị mma a hụrụ na ule patch, ọ dịghịkwa phototoxicity gosiri. Ọ bụ kpọmkwem n'ihi ọtụtụ uru HPR na ụdị ndị gụnyere Estee Lauder ji ya mee ihe, ma ugbu a amalitela ịbanye n'ụdị ngwaahịa nlekọta anụ ụlọ.

Hydroxypinacolone Retinoate soplaya

Yuantai Organic Bio na-agba mbọ inye ndị ahịa nnukwu ihe kacha mma HPR ntụ ntụ na ọrụ ka onye ọ bụla na-azụ ahịa nwee ike ịnụ ụtọ nri eke, ahụike yana oke mma. Ọ bụrụ na ị nwere ajụjụ ọ bụla ma ọ bụ mkpa gbasara ngwaahịa anyị, biko nweere onwe gị ịkpọtụrụ anyị, anyị ga-azaghachi gị ozugbo enwere ike.

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