Panthenol dị ọcha

Kedu ihe bụ D-panthenol?

D-panthenol bụ ihe mmepụta nke vitamin B5, nke a makwaara dị ka provitamin B5. Vitamin B5 bụ pantothenic acid. Ngwongwo ya anaghị eguzosi ike ma dị mfe site na okpomọkụ na usoro, na-eme ka bioavailability ya belata. Ya mere, a na-ejikarị panthenol eme ihe n'ụdị ihe ịchọ mma. Panthenol dị n'ụdị atọ: ahụ dextrorotary (D-form), ahụ aka ekpe (L-ụdị) na ahụ agwakọta (DL-form). N'ime ha, dexpanthenol (D-panthenol) nwere elu Biologically na-arụ ọrụ, D-panthenol na-ejikarị na ụlọ ọrụ ịchọ mma.

Panthenol bụ mmiri na-enweghị agba, nke nwere obere viscosity na obere isi pụrụ iche. E jiri ya tụnyere vitamin B5 ma ọ bụ pantothenic acid, panthenol kwụsiri ike na okike. Ibu molekụla ya dị naanị 205. Ọ nwere ike ịbanye n'ime stratum corneum nke ọma wee gbanwee ngwa ngwa n'ime vitamin B5. Nke ikpeazụ bụ akụkụ dị mkpa nke metabolism nke ahụ ma na-ahụ maka njikọ nke coenzyme A. ihe dị mkpa akụrụngwa. Coenzyme A bụ onye na-akwado ụzọ mmeghachi omume enzyme dị iche iche n'ime ahụ. Ọ na-ekere òkè na metabolism ike cell ma na-enye ume maka ọrụ ndụ nke ahụ. Na mgbakwunye, ọ na-ekere òkè na metabolism nke akụkụ dị iche iche dị mkpa na akpụkpọ ahụ, dị ka njikọ nke cholesterol, fatty acids na sphingolipids. chere.

Ya mere, a na-eji panthenol eme ihe n'ọtụtụ ebe na ụlọ ọrụ ọgwụ, nri na ịchọ mma. N'ime ụlọ ọrụ nri, panthenol nwere ike iji dị ka ihe mgbakwunye nri na ihe na-agba ume; ojiji a na-eji panthenol eme ihe na akpụkpọ ahụ malitere na 1944 ma nwee akụkọ ihe mere eme nke ihe karịrị afọ 70. Ọ na-abụkarị ọrụ nke moisturizing, na-eme ka ahụ dị jụụ na ịrụzi ihe na ịchọ mma.

Ọ bụ mmalite nke vitamin B5 na a na-ahụ ya n'ọtụtụ nri sitere na osisi na anụmanụ. Panthenol nwere ike banye n'ime stratum corneum ma ghọọ pantothenic acid, nke nwere ike ịmepụta coenzyme A ma kwalite metabolism nke protein, abụba na shuga n'ime ahụ mmadụ. Panthenol nwere moisturizing na mgbochi ịka nká mmetụta na akpụkpọ, na-akwalite nkịtị keratinization nke anụ ahụ, na-akwalite ọnya na-agwọ ọrịa, na nwere mgbochi mkpali mmetụta.

Kedu uru ọ bara maka akpụkpọ ahụ?

Hydrates ma na-emezi ihe mgbochi

Lipids intercellular dị na stratum corneum bụ ihe dị mkpa n'ịkwado ọrụ mgbochi nke akpụkpọ ahụ. Nnyocha ọhụrụ achọpụtala na nhazi nke lipids intercellular na stratum corneum nke akpụkpọ anụ dị iche iche, ọ dịkwa na gburugburu ebe siri ike na mmiri adịghị mma.

Panthenol, n'ihi na ọ nwere hygroscopic na mmiri na-ejigide ihe onwunwe, na-akwalite njikọ nke lipid ma na-eme ka mmiri nke mkpụrụ ndụ lipid na keratin microfilaments dịkwuo mma, ọ nwere ike imeziwanye gburugburu ebe obibi siri ike n'etiti mkpụrụ ndụ stratum corneum ma nyere aka ịnọgide na-enwe ahụ ike. Ihe mgbochi nlekọta anụ ahụ uru.

Nsonaazụ nyocha sitere na Laboratory Vicèhu na Switzerland na-egosi na iji ngwaahịa nwere panthenol na akpụkpọ ahụ dị mma nwere ike ịbawanye ọdịnaya mmiri nke stratum corneum nke ọma, yana enwere mmekọrịta na-emetụta dose.

Na mgbakwunye, mgbe surfactants mebiri ọrụ mgbochi akpụkpọ ahụ, iji ngwaahịa nwere panthenol nwere ike belata mfu mmiri transepidermal nke ọma ma melite ọrụ mgbochi akpụkpọ ahụ.

Na-emegharị ahụ

Mmetụta obi ụtọ nke D-panthenol ntụ ntụ tumadi sitere n'akụkụ abụọ.

N'otu aka ahụ, ubiquinol na-echebe megide mmebi nrụgide oxidative. Selụ ga-emepụta oxygen free radicals na-emeghachi omume n'okpuru ọrụ nke ihe nrụgide dị n'ime na nke mpụga. Mgbe mkpụrụ ndụ na-enwechaghị ikike ịsacha ihe nfụkasị n'efu, radicals efu a na-akwakọba ga-enwe mmetụta ọjọọ na ahụike anụ ahụ na ịka nká. Panthenol n'oge a nwere ike ibelata mmepụta nke reactive oxygen free radicals na akpụkpọ anụ, ma n'otu oge ahụ na-edozi usoro antioxidant nke anụ ahụ, gụnyere ime ka mkpụrụ ndụ akpụkpọ ahụ gosipụta ihe ndị ọzọ antioxidant - heme oxygenase 1 (HO-1), si otú ahụ na-emeziwanye. ikike antioxidant anụ ahụ.

N'aka nke ọzọ, panthenol nwere ike ibelata mmeghachi omume mkpali nke akpụkpọ ahụ, gbochie ntọhapụ nke ihe ndị na-egbuke egbuke, si otú ahụ na-ebelata mmeghachi omume mkpali, ma na-emeziwanye ihe mgbaàmà akpụkpọ anụ dị iche iche nke ọma, gụnyere akpụkpọ anụ akọrọ, isi ike, akpịrịkpa, itching, erythema. chapped, wdg.

Kwalite mmezi

Ndozi mmebi akpụkpọ ahụ bụ usoro dị mgbagwoju anya, nke gụnyere nkebi anọ: hemostasis, mbufụt, mmụba na nhazigharị.

Mgbe obere ịwa ahụ gasịrị, akpụkpọ ahụ ga-emebi. Ojiji nke ngwaahịa nwere panthenol nwere ike kwalite n'ụzọ dị irè na mmụgharị nke epidermis akpụkpọ ahụ, na-akwalite mmụba na ọdịiche nke mkpụrụ ndụ epidermal, ma mee ka nrụzi nke epidermal mebiri site na laser. N'otu oge ahụ, filaggrin, akara dị mkpa nke keratinocyte dị iche iche na ọrụ mgbochi, mụbara nke ukwuu, na-egosi na ubiquinol nwere mmetụta dị mma na-arụ ọrụ n'ịkwalite nrụzi ihe mgbochi akpụkpọ ahụ.

Moisturizing

Panthenol dị ọcha nwere obere ihe dị arọ ma nwee ike banye n'ime stratum corneum nke ọma wee banye n'ime stratum corneum n'elu akpụkpọ ahụ. Ọ nwere mmetụta moisturize siri ike, na-eme ka akpụkpọ ahụ dị nro dịkwuo mma, na-eme ka akpụkpọ ahụ dị nro na-adịghị mma.

mmezi

Na-akwalite uto nke mkpụrụ ndụ epithelial, na-eme ka oge ọgwụgwọ nke ọnya epidermal dịkwuo elu, na-edozi ọnyá anụ ahụ; ọ na-arụ ọrụ nke ọma n'ịgwọ eczema, ntachu anwụ, na ihe ọkụ ọkụ ụmụaka. Enwere akụkọ na akwụkwọ: Ude nwere 5% panthenol nwere ike mee ka oge ọgwụgwọ nke ọnya epidermal dị ngwa ngwa site na 30%.

Lụọ ọgụ akpụkpọ anụ

Panthenol dị ọcha nwere ike igbochi ntọhapụ nke ihe ndị na-egbuke egbuke, si otú ahụ belata nzaghachi mkpali na ime ka anụ ahụ dị nro. Nnyocha nyocha egosila na mgbe ejiri capsaicin na-akpali keratinocytes, ntọhapụ nke ihe mkpali IL-6 na IL-8 mụbara nke ukwuu. Mgbe o jiri ubiquinol mee ihe, a na-egbochi ntọhapụ nke ihe na-egbuke egbuke IL-6 na IL-8 nke ọma. , na-egosi na ubiquinol nwere ike igbochi ntọhapụ nke ihe ndị na-egbuke egbuke.

Nnwale nnwale

FLÁVIO B nke Mahadum São Paulo mere nnyocha nke 0.5%, 1.0%, na 5.0% panthenol na-agbakwunyere na usoro ahụ ma tinye ya n'ihu nke ihe ndị dị mma kwa ụbọchị, mgbe ahụ, a na-anwale mmiri mmiri nke anụ ahụ na mmiri transepidermal. mgbe 15 na 30 ụbọchị. Transepidermal Waterloss (TWEL). N'oge ule ahụ, ihe ndị ahụ nwere ike ịsa ahụ nke ọma, mana enweghị ike iji ngwaahịa nlekọta anụ ahụ na ogwe aka ha.

Otu njikwa: enweghị usoro; ụgbọ ala otu: usoro enweghị panthenol

Ọgụgụ 1 Mgbanwe na ọdịnaya mmiri nke stratum corneum mgbe ejiri ngwaahịa ahụ maka ụbọchị 15 na 30 (* na-anọchi anya nnukwu ọdịiche)

Dị ka egosiri na eserese 1, mgbe ụbọchị 15 na 30 gachara, ngwaahịa niile nwere ike ịbawanye ọdịnaya nke stratum corneum nke anụ ahụ, mmetụta nke usoro nwere panthenol pụtakwara ìhè.

Ọgụgụ 2 Mgbanwe na TEWL mgbe ejiri ngwaahịa ahụ maka ụbọchị 15 na 30 (* na-anọchi anya nnukwu ọdịiche)

Dị ka e gosiri na foto 2, nsonaazụ ule transepidermal (TEWL) gosipụtara na usoro ndị na-agbakwunye 1.0% na 5.0% panthenol mere ka ọrụ mgbochi akpụkpọ ahụ dịkwuo mma, ya bụ, ụkpụrụ TEWL na-ebelata nke ukwuu mgbe 15 na 30 ụbọchị ejiri.

Ọnụọgụ 3 Mgbanwe na ọdịnaya mmiri (A) na TEWL (B) nke stratum corneum tupu ịsacha SLES, mgbe ịsacha SLES maka ụbọchị 5 na mgbe ejiri ngwaahịa ahụ maka awa 2 (★ na-anọchite anya elu dị elu; • na-anọchi anya nke ọma ala)

Dị ka egosiri na eserese 3, mgbe ụbọchị 5 nke na-aga n'ihu na-asachapụ akpụkpọ ahụ na SLES (sodium laureth sulfate), ọdịnaya mmiri nke stratum corneum akpụkpọ ahụ belatara nke ukwuu na TEWL mụbara nke ukwuu. E belatara ụkpụrụ TEWL nke ukwuu site na iji usoro nwere 1.0% na 5.0% panthenol. Ya mere, ule ịsacha SLES gosipụtara na mgbe arụ ọrụ mgbochi akpụkpọ ahụ gbanwere, usoro nwere 1.0% na 5.0% panthenol nwere ike belata oke mmiri transepidermal.

Nchịkọta: uru mmiri transepidermal (TEWL) bụ isi ihe maka nchọpụta na-adịghị emerụ ahụ na ebumnuche nke ọrụ mgbochi akpụkpọ ahụ. Ọ bụkwa otu n'ime ihe ndị dị mkpa maka nyocha arụmọrụ nke ihe ịchọ mma moisturizing. A na-ejikarị ya nyochaa nrụpụta nrụzi nke ngwaahịa nlekọta anụ ahụ. Iji usoro nke nwere panthenol nwere ike ime ka mmiri dị na stratum corneum dịkwuo elu (ya bụ, panthenol nwere mmetụta dị nro) ma melite ihe mgbochi akpụkpọ ahụ site n'ibelata TEWL (ya bụ, panthenol nwere mmetụta na-arụzi). 1.0% panthenol enweela ezigbo ọrụ mgbochi akpụkpọ anụ, ya mere enwere ike iji ya na ngwaahịa nlekọta anụ ahụ iji nọgide na-enwe ọnọdụ anụ ahụ nke anụ ahụ ma gbochie nkụchi anụ ahụ, n'ihi na mmiri na-efunahụ nwere ike imetụta ọdịdị akpụkpọ ahụ ma mee ka ọ dị njọ. ọrịa akpụkpọ.

D-panthenol soplaya

Yuantai Organic Bio na-agba mbọ inye ndị ahịa ihe kacha mma D-panthenol ntụ ntụ dị ọcha na ọrụ ka onye ọ bụla na-azụ ahịa nwee ike ịnụ ụtọ nri eke, ahụike yana oke mma. Ọ bụrụ na ị nwere ajụjụ ọ bụla ma ọ bụ mkpa gbasara ngwaahịa anyị, biko nweere onwe gị ịkpọtụrụ anyị, anyị ga-azaghachi gị ozugbo enwere ike.

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